SG66499A1 - Process for the manufacture of amorphous products by means of convection drying - Google Patents

Process for the manufacture of amorphous products by means of convection drying

Info

Publication number
SG66499A1
SG66499A1 SG9804416A SG1998004416A SG66499A1 SG 66499 A1 SG66499 A1 SG 66499A1 SG 9804416 A SG9804416 A SG 9804416A SG 1998004416 A SG1998004416 A SG 1998004416A SG 66499 A1 SG66499 A1 SG 66499A1
Authority
SG
Singapore
Prior art keywords
manufacture
convection drying
amorphous products
amorphous
products
Prior art date
Application number
SG9804416A
Other languages
English (en)
Inventor
Gabel Rolf-Dieter
Mattern Markus
Winter Gerhard
Wirl Alexander
Woog Heinrich
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of SG66499A1 publication Critical patent/SG66499A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
SG9804416A 1997-11-03 1998-11-03 Process for the manufacture of amorphous products by means of convection drying SG66499A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97119112A EP0913177A1 (fr) 1997-11-03 1997-11-03 Procédé pour produire des produits amorphe, sec comprenant de la matière biologique active par séchage convectif, spécialement söchage par pulvérisation

Publications (1)

Publication Number Publication Date
SG66499A1 true SG66499A1 (en) 2002-04-16

Family

ID=8227559

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9804416A SG66499A1 (en) 1997-11-03 1998-11-03 Process for the manufacture of amorphous products by means of convection drying

Country Status (28)

Country Link
US (1) US6689755B1 (fr)
EP (1) EP0913177A1 (fr)
JP (2) JPH11228389A (fr)
KR (1) KR100629378B1 (fr)
CN (1) CN1163288C (fr)
AR (1) AR015998A1 (fr)
AU (1) AU743232B2 (fr)
BR (1) BR9804739A (fr)
CA (1) CA2253154C (fr)
CZ (1) CZ297917B6 (fr)
HK (1) HK1020689A1 (fr)
HR (1) HRP980575B1 (fr)
HU (1) HU221346B1 (fr)
ID (1) ID21204A (fr)
IL (1) IL126828A0 (fr)
MA (1) MA26561A1 (fr)
MY (1) MY118853A (fr)
NO (1) NO326204B1 (fr)
NZ (1) NZ332596A (fr)
PE (1) PE127199A1 (fr)
PL (1) PL196456B1 (fr)
RU (1) RU2233105C2 (fr)
SA (1) SA99191068B1 (fr)
SG (1) SG66499A1 (fr)
TR (1) TR199802204A3 (fr)
TW (1) TW575433B (fr)
YU (1) YU49598A (fr)
ZA (1) ZA9810002B (fr)

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US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0913177A1 (fr) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Procédé pour produire des produits amorphe, sec comprenant de la matière biologique active par séchage convectif, spécialement söchage par pulvérisation
MXPA02008261A (es) 2000-02-24 2002-11-29 Monsanto Technology Llc Formulaciones inyectables no acuosas para liberacion prolongada de somatotorpina.
KR20030023878A (ko) 2000-06-26 2003-03-20 몬산토 테크놀로지 엘엘씨 소마토트로핀의 지속적인 방출을 위한 계면활성제 함유비수성 제제들
US6664234B1 (en) 2000-06-30 2003-12-16 Monsanto Technology Llc Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
UA78273C2 (en) * 2002-01-16 2007-03-15 Boehringer Ingelheim Pharma Bilayer pharmaceutical tablet containing telmisartan and hydrochlorothiazide and method for producing thereof
AU2005254062B2 (en) * 2002-04-11 2011-02-17 Medimmune, Llc High pressure spray-dry of bioactive materials
WO2004058156A2 (fr) * 2002-12-17 2004-07-15 Medimmune Vaccines, Inc. Pulvérisation haute pression de matériaux bioactifs
HU227041B1 (en) * 2003-03-24 2010-05-28 Richter Gedeon Nyrt Process for the synthesis of amorphous atorvastatin calcium
CA2567720A1 (fr) 2004-05-24 2005-12-08 Genvault Corporation Stockage proteique stable et stockage d'acides nucleiques stable sous forme recuperable
EP1912730A2 (fr) * 2005-07-28 2008-04-23 Isp Investments Inc. Procede d'amelioration des caracteristiques de poudres sechees par atomisation et de materiaux granules, et produits obtenus par ce procede
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
US20080152717A1 (en) * 2006-12-14 2008-06-26 Isp Investments, Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
US10189957B2 (en) * 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
US20080181961A1 (en) * 2007-01-26 2008-07-31 Isp Investments, Inc. Amorphous oxcarbazepine and the production thereof
WO2009155612A2 (fr) * 2008-06-20 2009-12-23 Genvault Corporation Dispositifs de collecte et de stockage d'échantillons et procédés d'utilisation associés
CN102177237B (zh) 2008-09-12 2013-10-30 金沃特公司 用于贮存和稳定生物分子的基质和介质
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
WO2013025274A1 (fr) * 2011-08-12 2013-02-21 Merial Limited Conservation sous vide de produits biologiques, et en particulier de vaccins
IL303832A (en) 2011-11-18 2023-08-01 Regeneron Pharma Microparticles of polymeric proteins
FR2988091B1 (fr) * 2012-03-16 2014-08-15 Innov Ia 3I Compositions pulverulentes d'un complexe entre un acide et un metal et leur procede de preparation
JP2016512839A (ja) * 2013-03-15 2016-05-09 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 治療物質の送達のための生体内分解性ケイ素系組成物
CN108366968B (zh) * 2015-12-16 2022-02-18 瑞泽恩制药公司 制造蛋白质微粒的组合物和方法
RU2659685C1 (ru) * 2017-03-27 2018-07-03 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ сорбционно-вакуумного высушивания жидких термолабильных биологически активных материалов
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
WO2019028446A1 (fr) 2017-08-04 2019-02-07 ZoomEssence, Inc. Appareil et procédé de séchage par pulvérisation à très haut rendement
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
CN114797135B (zh) * 2022-06-29 2022-11-18 四川富临新能源科技有限公司 喷雾干燥法制备锂离子电池活性材料超细粉的设备和方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520748A1 (fr) * 1991-06-26 1992-12-30 Pafra Limited Emmagasinage de matériaux
WO1996032096A1 (fr) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Preparation pharmaceutique en poudre a dispersibilite accrue
WO1997015288A2 (fr) * 1995-10-25 1997-05-01 Boehringer Mannheim Gmbh Preparations et procedes pour stabiliser des materiaux biologiques a l'aide de procedes de dessiccation sans congelation

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US3281216A (en) * 1961-11-03 1966-10-25 Nalco Chemical Co Method of producing amorphous saltfree silica powder capable of forming a sol in aqueous lower alkyl amine solutions
BE759520A (fr) 1969-11-28 1971-04-30 Aspro Nicholas Ltd Compositions d'aspirine
JPS60258125A (ja) 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
EP0229810B1 (fr) 1985-07-09 1991-10-16 Quadrant Bioresources Limited Protection des proteines et similaires
JPH0678226B2 (ja) * 1985-12-11 1994-10-05 株式会社林原生物化学研究所 脱水医薬品とその製造方法
US4734401A (en) 1986-03-17 1988-03-29 W. R. Grace & Co. Process for spray drying amino acid compositions
DE3801179A1 (de) 1988-01-18 1989-07-27 Hoechst Ag Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
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US5200399A (en) 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
DE4141351A1 (de) 1991-12-14 1993-06-17 Basf Ag Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung
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IL116085A (en) * 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
EP0913177A1 (fr) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Procédé pour produire des produits amorphe, sec comprenant de la matière biologique active par séchage convectif, spécialement söchage par pulvérisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520748A1 (fr) * 1991-06-26 1992-12-30 Pafra Limited Emmagasinage de matériaux
WO1996032096A1 (fr) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Preparation pharmaceutique en poudre a dispersibilite accrue
WO1997015288A2 (fr) * 1995-10-25 1997-05-01 Boehringer Mannheim Gmbh Preparations et procedes pour stabiliser des materiaux biologiques a l'aide de procedes de dessiccation sans congelation

Also Published As

Publication number Publication date
NO985096L (no) 1999-05-04
AR015998A1 (es) 2001-05-30
HU221346B1 (en) 2002-09-28
JPH11228389A (ja) 1999-08-24
TR199802204A2 (xx) 1999-05-21
ID21204A (id) 1999-05-06
CA2253154A1 (fr) 1999-05-03
MA26561A1 (fr) 2004-12-20
KR100629378B1 (ko) 2007-03-02
SA99191068B1 (ar) 2006-04-04
RU2233105C2 (ru) 2004-07-27
EP0913177A1 (fr) 1999-05-06
CN1222403A (zh) 1999-07-14
YU49598A (sh) 2001-07-10
CZ297917B6 (cs) 2007-04-25
JP2010163456A (ja) 2010-07-29
PL329467A1 (en) 1999-05-10
ZA9810002B (en) 1999-05-03
AU9045998A (en) 1999-05-20
NO985096D0 (no) 1998-11-02
PL196456B1 (pl) 2008-01-31
US6689755B1 (en) 2004-02-10
HRP980575B1 (en) 2002-06-30
TW575433B (en) 2004-02-11
HK1020689A1 (en) 2000-05-19
BR9804739A (pt) 1999-11-09
IL126828A0 (en) 1999-08-17
CN1163288C (zh) 2004-08-25
CZ348798A3 (cs) 1999-05-12
TR199802204A3 (tr) 1999-05-21
NZ332596A (en) 2000-12-22
HU9802516D0 (en) 1999-01-28
KR19990044951A (ko) 1999-06-25
NO326204B1 (no) 2008-10-20
CA2253154C (fr) 2008-07-08
HRP980575A2 (en) 1999-06-30
PE127199A1 (es) 1999-12-14
HUP9802516A3 (en) 2000-05-29
HUP9802516A2 (hu) 1999-07-28
AU743232B2 (en) 2002-01-24
MY118853A (en) 2005-01-31

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