SG52631A1 - Process for the enantioselection sznthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine - Google Patents
Process for the enantioselection sznthesis of alkylated oxindoles used as intermediates in the preparation of physostigmineInfo
- Publication number
- SG52631A1 SG52631A1 SG1996007048A SG1996007048A SG52631A1 SG 52631 A1 SG52631 A1 SG 52631A1 SG 1996007048 A SG1996007048 A SG 1996007048A SG 1996007048 A SG1996007048 A SG 1996007048A SG 52631 A1 SG52631 A1 SG 52631A1
- Authority
- SG
- Singapore
- Prior art keywords
- physostigmine
- sznthesis
- enantioselection
- intermediates
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46988290A | 1990-01-22 | 1990-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG52631A1 true SG52631A1 (en) | 1998-09-28 |
Family
ID=23865415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996007048A SG52631A1 (en) | 1990-01-22 | 1990-12-28 | Process for the enantioselection sznthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0438796B1 (ja) |
| JP (1) | JPH0757747B2 (ja) |
| KR (1) | KR0175933B1 (ja) |
| AT (1) | ATE170173T1 (ja) |
| AU (1) | AU631957B2 (ja) |
| CA (1) | CA2034668A1 (ja) |
| CZ (1) | CZ278815B6 (ja) |
| DE (1) | DE69032595T2 (ja) |
| DK (1) | DK0438796T3 (ja) |
| ES (1) | ES2120407T3 (ja) |
| HK (1) | HK1011993A1 (ja) |
| HR (1) | HRP930321B1 (ja) |
| HU (2) | HUT56539A (ja) |
| IE (1) | IE910194A1 (ja) |
| IL (1) | IL97002A (ja) |
| LT (1) | LT3982B (ja) |
| NZ (1) | NZ236837A (ja) |
| PH (1) | PH30059A (ja) |
| PT (1) | PT96534B (ja) |
| RU (1) | RU2072354C1 (ja) |
| SG (1) | SG52631A1 (ja) |
| YU (1) | YU9891A (ja) |
| ZA (1) | ZA91410B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE125254T1 (de) * | 1989-09-19 | 1995-08-15 | Hoechst Roussel Pharma | Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen. |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| US5521320A (en) * | 1990-01-22 | 1996-05-28 | Hoechst-Roussel Pharmaceuticals Incorporated | Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine |
| US5840915A (en) * | 1990-01-22 | 1998-11-24 | Hoechst Marion Roussel, Inc. | Process for the enatioselective synthesis of intermediates used |
| US6596870B2 (en) | 2000-07-13 | 2003-07-22 | Brandeis University | Asymmetric synthetic methods based on phase transfer catalysis |
| JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
| WO2013069731A1 (ja) * | 2011-11-08 | 2013-05-16 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物 |
| AU2013232191B2 (en) * | 2012-03-14 | 2017-03-30 | Merck Sharp & Dohme Llc | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4578509A (en) | 1983-04-01 | 1986-03-25 | Merck & Co., Inc. | Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis |
| US4791107A (en) | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| ATE125254T1 (de) * | 1989-09-19 | 1995-08-15 | Hoechst Roussel Pharma | Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen. |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| AU700888B2 (en) | 1994-11-28 | 1999-01-14 | Minnesota Mining And Manufacturing Company | Articles exhibiting durable colour and/or fluorescent properties |
-
1990
- 1990-12-28 DE DE69032595T patent/DE69032595T2/de not_active Expired - Fee Related
- 1990-12-28 SG SG1996007048A patent/SG52631A1/en unknown
- 1990-12-28 DK DK90125644T patent/DK0438796T3/da active
- 1990-12-28 EP EP90125644A patent/EP0438796B1/en not_active Expired - Lifetime
- 1990-12-28 AT AT90125644T patent/ATE170173T1/de not_active IP Right Cessation
- 1990-12-28 ES ES90125644T patent/ES2120407T3/es not_active Expired - Lifetime
-
1991
- 1991-01-18 NZ NZ236837A patent/NZ236837A/xx unknown
- 1991-01-21 ZA ZA91410A patent/ZA91410B/xx unknown
- 1991-01-21 KR KR1019910000934A patent/KR0175933B1/ko not_active IP Right Cessation
- 1991-01-21 HU HU91210A patent/HUT56539A/hu unknown
- 1991-01-21 PH PH41878A patent/PH30059A/en unknown
- 1991-01-21 CZ CS91123A patent/CZ278815B6/cs not_active IP Right Cessation
- 1991-01-21 AU AU69496/91A patent/AU631957B2/en not_active Ceased
- 1991-01-21 IE IE019491A patent/IE910194A1/en not_active IP Right Cessation
- 1991-01-21 RU SU914894301A patent/RU2072354C1/ru active
- 1991-01-21 PT PT96534A patent/PT96534B/pt not_active IP Right Cessation
- 1991-01-21 JP JP3078153A patent/JPH0757747B2/ja not_active Expired - Lifetime
- 1991-01-21 HU HU9801313A patent/HU9801313D0/hu unknown
- 1991-01-21 CA CA002034668A patent/CA2034668A1/en not_active Abandoned
- 1991-01-21 YU YU9891A patent/YU9891A/sh unknown
- 1991-01-22 IL IL9700291A patent/IL97002A/en not_active IP Right Cessation
-
1993
- 1993-03-11 HR HRP-98/91A patent/HRP930321B1/xx not_active IP Right Cessation
- 1993-12-20 LT LTIP1629A patent/LT3982B/lt not_active IP Right Cessation
-
1998
- 1998-12-14 HK HK98113299A patent/HK1011993A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0438796A2 (en) | 1991-07-31 |
| HK1011993A1 (en) | 1999-07-23 |
| AU631957B2 (en) | 1992-12-10 |
| KR0175933B1 (ko) | 1999-03-20 |
| CZ278815B6 (en) | 1994-07-13 |
| IL97002A (en) | 1994-10-21 |
| CA2034668A1 (en) | 1991-07-23 |
| YU9891A (sh) | 1994-06-24 |
| HRP930321B1 (en) | 1999-02-28 |
| HUT56539A (en) | 1991-09-30 |
| LT3982B (en) | 1996-06-25 |
| EP0438796A3 (en) | 1992-03-18 |
| DE69032595T2 (de) | 1999-03-25 |
| NZ236837A (en) | 1993-03-26 |
| DK0438796T3 (da) | 1999-05-25 |
| JPH0757747B2 (ja) | 1995-06-21 |
| LTIP1629A (en) | 1995-07-25 |
| EP0438796B1 (en) | 1998-08-26 |
| CS9100123A2 (en) | 1991-09-15 |
| HRP930321A2 (en) | 1996-08-31 |
| PH30059A (en) | 1996-11-08 |
| ES2120407T3 (es) | 1998-11-01 |
| PT96534B (pt) | 1998-07-31 |
| ZA91410B (en) | 1991-10-30 |
| HU910210D0 (en) | 1991-08-28 |
| KR910014349A (ko) | 1991-08-31 |
| JPH04342566A (ja) | 1992-11-30 |
| IE910194A1 (en) | 1991-07-31 |
| HU9801313D0 (en) | 1998-08-28 |
| AU6949691A (en) | 1991-07-25 |
| IL97002A0 (en) | 1992-03-29 |
| RU2072354C1 (ru) | 1997-01-27 |
| PT96534A (pt) | 1991-10-15 |
| DE69032595D1 (de) | 1998-10-01 |
| ATE170173T1 (de) | 1998-09-15 |
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