AU631957B2 - Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine - Google Patents

Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine Download PDF

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Publication number
AU631957B2
AU631957B2 AU69496/91A AU6949691A AU631957B2 AU 631957 B2 AU631957 B2 AU 631957B2 AU 69496/91 A AU69496/91 A AU 69496/91A AU 6949691 A AU6949691 A AU 6949691A AU 631957 B2 AU631957 B2 AU 631957B2
Authority
AU
Australia
Prior art keywords
oxindole
enantiomers
mixture
solvent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69496/91A
Other languages
English (en)
Other versions
AU6949691A (en
Inventor
Thomas Bing Kin Lee
George S.K. Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of AU6949691A publication Critical patent/AU6949691A/en
Application granted granted Critical
Publication of AU631957B2 publication Critical patent/AU631957B2/en
Assigned to HOECHST MARION ROUSSEL, INC. reassignment HOECHST MARION ROUSSEL, INC. Alteration of Name(s) in Register under S187 Assignors: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU69496/91A 1990-01-22 1991-01-21 Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine Ceased AU631957B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46988290A 1990-01-22 1990-01-22
US469882 1990-01-22

Publications (2)

Publication Number Publication Date
AU6949691A AU6949691A (en) 1991-07-25
AU631957B2 true AU631957B2 (en) 1992-12-10

Family

ID=23865415

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69496/91A Ceased AU631957B2 (en) 1990-01-22 1991-01-21 Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine

Country Status (23)

Country Link
EP (1) EP0438796B1 (ja)
JP (1) JPH0757747B2 (ja)
KR (1) KR0175933B1 (ja)
AT (1) ATE170173T1 (ja)
AU (1) AU631957B2 (ja)
CA (1) CA2034668A1 (ja)
CZ (1) CZ278815B6 (ja)
DE (1) DE69032595T2 (ja)
DK (1) DK0438796T3 (ja)
ES (1) ES2120407T3 (ja)
HK (1) HK1011993A1 (ja)
HR (1) HRP930321B1 (ja)
HU (2) HUT56539A (ja)
IE (1) IE910194A1 (ja)
IL (1) IL97002A (ja)
LT (1) LT3982B (ja)
NZ (1) NZ236837A (ja)
PH (1) PH30059A (ja)
PT (1) PT96534B (ja)
RU (1) RU2072354C1 (ja)
SG (1) SG52631A1 (ja)
YU (1) YU9891A (ja)
ZA (1) ZA91410B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE125254T1 (de) * 1989-09-19 1995-08-15 Hoechst Roussel Pharma Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen.
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5521320A (en) * 1990-01-22 1996-05-28 Hoechst-Roussel Pharmaceuticals Incorporated Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
US5840915A (en) * 1990-01-22 1998-11-24 Hoechst Marion Roussel, Inc. Process for the enatioselective synthesis of intermediates used
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
WO2013069731A1 (ja) * 2011-11-08 2013-05-16 日産化学工業株式会社 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
AU2013232191B2 (en) * 2012-03-14 2017-03-30 Merck Sharp & Dohme Llc Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6262990A (en) * 1989-09-19 1991-03-28 Hoechst Marion Roussel, Inc. Process for the chemical resolution of 5-alkoxy-substituted (+ or -)-1,3-dimethyloxindolylethylamines
AU6571290A (en) * 1989-09-28 1991-05-23 Hoechst Marion Roussel, Inc. 4- and 6-carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578509A (en) 1983-04-01 1986-03-25 Merck & Co., Inc. Process for preparing a manipulated enantiomer mixture by asymmetric chiral phase transfer catalysis
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
AU700888B2 (en) 1994-11-28 1999-01-14 Minnesota Mining And Manufacturing Company Articles exhibiting durable colour and/or fluorescent properties

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6262990A (en) * 1989-09-19 1991-03-28 Hoechst Marion Roussel, Inc. Process for the chemical resolution of 5-alkoxy-substituted (+ or -)-1,3-dimethyloxindolylethylamines
AU6571290A (en) * 1989-09-28 1991-05-23 Hoechst Marion Roussel, Inc. 4- and 6-carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments

Also Published As

Publication number Publication date
EP0438796A2 (en) 1991-07-31
HK1011993A1 (en) 1999-07-23
KR0175933B1 (ko) 1999-03-20
CZ278815B6 (en) 1994-07-13
IL97002A (en) 1994-10-21
CA2034668A1 (en) 1991-07-23
YU9891A (sh) 1994-06-24
HRP930321B1 (en) 1999-02-28
HUT56539A (en) 1991-09-30
LT3982B (en) 1996-06-25
EP0438796A3 (en) 1992-03-18
DE69032595T2 (de) 1999-03-25
NZ236837A (en) 1993-03-26
DK0438796T3 (da) 1999-05-25
JPH0757747B2 (ja) 1995-06-21
LTIP1629A (en) 1995-07-25
EP0438796B1 (en) 1998-08-26
CS9100123A2 (en) 1991-09-15
HRP930321A2 (en) 1996-08-31
PH30059A (en) 1996-11-08
ES2120407T3 (es) 1998-11-01
PT96534B (pt) 1998-07-31
ZA91410B (en) 1991-10-30
HU910210D0 (en) 1991-08-28
KR910014349A (ko) 1991-08-31
JPH04342566A (ja) 1992-11-30
IE910194A1 (en) 1991-07-31
HU9801313D0 (en) 1998-08-28
AU6949691A (en) 1991-07-25
IL97002A0 (en) 1992-03-29
RU2072354C1 (ru) 1997-01-27
PT96534A (pt) 1991-10-15
DE69032595D1 (de) 1998-10-01
SG52631A1 (en) 1998-09-28
ATE170173T1 (de) 1998-09-15

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AU631957B2 (en) Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine
US5274117A (en) Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
US5521320A (en) Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
JP5822880B2 (ja) （７ｓ）−１−（３，４−ジメトキシビシクロ［４．２．０］オクタ−１，３，５−トリエン−７−イル）ｎ−メチルメタンアミンの酵素的合成方法、並びにイバブラジン及びその塩の合成における適用
US5387695A (en) Process for the chemical resolution of 5-alkoxy-substituted (+)-1,3-dimethyloxindolylethylamines
US5840915A (en) Process for the enatioselective synthesis of intermediates used
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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired