SG50571A1 - Process of preparing etoposide phosphate and etoposide - Google Patents

Process of preparing etoposide phosphate and etoposide

Info

Publication number
SG50571A1
SG50571A1 SG1996005289A SG1996005289A SG50571A1 SG 50571 A1 SG50571 A1 SG 50571A1 SG 1996005289 A SG1996005289 A SG 1996005289A SG 1996005289 A SG1996005289 A SG 1996005289A SG 50571 A1 SG50571 A1 SG 50571A1
Authority
SG
Singapore
Prior art keywords
etoposide
phosphate
etoposide phosphate
benzyl
preparing
Prior art date
Application number
SG1996005289A
Other languages
English (en)
Inventor
Lee J Silverberg
Purushotham Vemishetti
John L Dillon Jr
John J Usher
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG50571A1 publication Critical patent/SG50571A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
SG1996005289A 1993-11-04 1994-11-03 Process of preparing etoposide phosphate and etoposide SG50571A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/145,517 US5459248A (en) 1993-11-04 1993-11-04 Process of preparing etoposide phosphate and etoposide

Publications (1)

Publication Number Publication Date
SG50571A1 true SG50571A1 (en) 1998-07-20

Family

ID=22513464

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996005289A SG50571A1 (en) 1993-11-04 1994-11-03 Process of preparing etoposide phosphate and etoposide

Country Status (20)

Country Link
US (2) US5459248A (zh)
EP (1) EP0652226B1 (zh)
JP (2) JP2801152B2 (zh)
KR (1) KR100351325B1 (zh)
CN (4) CN1046290C (zh)
AT (1) ATE193018T1 (zh)
AU (1) AU692472B2 (zh)
CA (1) CA2133594C (zh)
CY (1) CY2201B1 (zh)
DE (1) DE69424504T2 (zh)
DK (1) DK0652226T3 (zh)
ES (1) ES2146247T3 (zh)
FI (1) FI115913B (zh)
GR (1) GR3034213T3 (zh)
HK (1) HK1003302A1 (zh)
HU (1) HU221969B1 (zh)
IL (1) IL111483A (zh)
PT (1) PT652226E (zh)
SG (1) SG50571A1 (zh)
TW (1) TW420687B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
ES2191733T3 (es) * 1995-12-04 2003-09-16 Nippon Kayaku Kk Procedimiento para producir etoposido.
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
HU228520B1 (en) * 1997-06-02 2013-03-28 Bristol Myers Squibb Co Process for preparing etoposide
CN1376159A (zh) 1998-09-10 2002-10-23 加拿大植原药物公司 抗肿瘤药亿妥谱赛的制造方法
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CN1626533A (zh) * 2000-04-19 2005-06-15 盐野义制药株式会社 磺酰胺衍生物的制备方法及其晶体
US20030082618A1 (en) * 2001-10-15 2003-05-01 Guangshan Li Methods for detecting genetic aberrations
WO2014052634A1 (en) * 2012-09-27 2014-04-03 The University Of North Carolina At Chapel Hill Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2666778A (en) * 1950-05-10 1954-01-19 George M Steinberg Method for the synthesis of organic phosphates
NL6613143A (zh) * 1965-09-21 1967-03-22
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
JPS62209089A (ja) * 1986-03-08 1987-09-14 Kuraray Co Ltd ドリシルグリコピラノシルクロロホスフエイト誘導体およびその製造方法
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
NZ225599A (en) * 1987-08-04 1991-09-25 Bristol Myers Co Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
US4888419A (en) * 1987-08-31 1989-12-19 Bristol-Myers Company 3'-demethoxyepipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CA2041280A1 (en) * 1990-05-10 1991-11-11 Yosuke Sawada Arylsulfatase
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (zh) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5375555A (en) * 1992-10-06 1994-12-27 Dolan; George D. Non-furling flag fasteners
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Also Published As

Publication number Publication date
ATE193018T1 (de) 2000-06-15
HUT72461A (en) 1996-04-29
AU7762794A (en) 1995-05-18
CN1056378C (zh) 2000-09-13
IL111483A0 (en) 1995-01-24
DE69424504T2 (de) 2000-09-21
CN1106016A (zh) 1995-08-02
CN1058017C (zh) 2000-11-01
CN1189500A (zh) 1998-08-05
IL111483A (en) 1998-12-06
KR100351325B1 (ko) 2002-10-31
EP0652226A1 (en) 1995-05-10
FI115913B (fi) 2005-08-15
DK0652226T3 (da) 2000-08-07
CN1061047C (zh) 2001-01-24
CN1189499A (zh) 1998-08-05
HU221969B1 (hu) 2003-03-28
PT652226E (pt) 2000-09-29
KR950014128A (ko) 1995-06-15
US5459248A (en) 1995-10-17
HU9403157D0 (en) 1994-12-28
CN1046290C (zh) 1999-11-10
FI945149A (fi) 1995-05-05
JPH10152499A (ja) 1998-06-09
DE69424504D1 (de) 2000-06-21
JP3810906B2 (ja) 2006-08-16
US5688926A (en) 1997-11-18
GR3034213T3 (en) 2000-12-29
HK1003302A1 (en) 1998-10-23
FI945149A0 (fi) 1994-11-01
CA2133594C (en) 1999-02-23
AU692472B2 (en) 1998-06-11
ES2146247T3 (es) 2000-08-01
CA2133594A1 (en) 1995-05-05
JPH07196680A (ja) 1995-08-01
CY2201B1 (en) 2002-11-08
TW420687B (en) 2001-02-01
CN1189497A (zh) 1998-08-05
EP0652226B1 (en) 2000-05-17
JP2801152B2 (ja) 1998-09-21

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