SG48059A1 - 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments - Google Patents
1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicamentsInfo
- Publication number
- SG48059A1 SG48059A1 SG1996006744A SG1996006744A SG48059A1 SG 48059 A1 SG48059 A1 SG 48059A1 SG 1996006744 A SG1996006744 A SG 1996006744A SG 1996006744 A SG1996006744 A SG 1996006744A SG 48059 A1 SG48059 A1 SG 48059A1
- Authority
- SG
- Singapore
- Prior art keywords
- loweralkyl
- hydrogen
- substituted
- arylloweralkyl
- indol
- Prior art date
Links
- -1 1-(Substituted pyridinylamino)-1h-indol-5-yl Chemical group 0.000 title abstract 4
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/555,890 US5102891A (en) | 1990-07-23 | 1990-07-23 | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG48059A1 true SG48059A1 (en) | 1998-04-17 |
Family
ID=24218998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996006744A SG48059A1 (en) | 1990-07-23 | 1991-07-22 | 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5102891A (cs) |
| EP (1) | EP0468401B1 (cs) |
| JP (1) | JP2564714B2 (cs) |
| KR (1) | KR100201515B1 (cs) |
| AT (1) | ATE171176T1 (cs) |
| AU (1) | AU639581B2 (cs) |
| BR (1) | BR1100534A (cs) |
| CA (1) | CA2047531C (cs) |
| CZ (1) | CZ283253B6 (cs) |
| DE (1) | DE69130196T2 (cs) |
| DK (1) | DK0468401T3 (cs) |
| ES (1) | ES2121761T3 (cs) |
| FI (1) | FI102067B (cs) |
| HU (1) | HUT58317A (cs) |
| IE (1) | IE912567A1 (cs) |
| IL (1) | IL98920A (cs) |
| MX (1) | MX9100342A (cs) |
| NO (1) | NO300132B1 (cs) |
| NZ (1) | NZ239038A (cs) |
| PL (1) | PL291185A1 (cs) |
| PT (1) | PT98413B (cs) |
| SG (1) | SG48059A1 (cs) |
| ZA (1) | ZA915723B (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264442A (en) * | 1990-08-13 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs |
| CZ284437B6 (cs) * | 1991-04-17 | 1998-11-11 | Hoechst Marion Roussel, Inc. | Substituované (pyridinylamino)-benzisoxazoly a -benzo[b]thiofeny, způsob jejich přípravy farmaceutický prostředek obsahující tyto sloučeniny a použití těchto sloučenin |
| US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| CA2276203C (en) * | 1996-12-27 | 2003-07-22 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino)isoindolines and related compounds |
| US6004977A (en) * | 1996-12-27 | 1999-12-21 | Hoechst Marion Roussel, Inc. | N-(pyridinylamino) isoindolines and related compounds |
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| GT200500063A (es) * | 2004-04-01 | 2005-10-14 | Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias | |
| FR2888238B1 (fr) * | 2005-07-07 | 2007-09-07 | Servier Lab | Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent. |
| AU2011215870B2 (en) * | 2010-02-09 | 2016-01-28 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| EP3827820A1 (en) | 2013-03-15 | 2021-06-02 | The Johns Hopkins University | Brivaracetam for improving cognitive function |
| AU2016268096B2 (en) | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| ES2065324T3 (es) * | 1987-04-24 | 1995-02-16 | Hoechst Roussel Pharma | N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos. |
| US4970218A (en) * | 1987-04-24 | 1990-11-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyridinyl)-1H-indol-1-amines |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| US4992448A (en) * | 1989-10-24 | 1991-02-12 | Hoechst-Roussel Pharmaceuticals Inc. | Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders |
-
1990
- 1990-07-23 US US07/555,890 patent/US5102891A/en not_active Expired - Fee Related
-
1991
- 1991-07-19 FI FI913502A patent/FI102067B/fi active IP Right Grant
- 1991-07-19 NZ NZ239038A patent/NZ239038A/en unknown
- 1991-07-22 AU AU81216/91A patent/AU639581B2/en not_active Expired - Fee Related
- 1991-07-22 IE IE256791A patent/IE912567A1/en not_active IP Right Cessation
- 1991-07-22 HU HU912450A patent/HUT58317A/hu unknown
- 1991-07-22 IL IL9892091A patent/IL98920A/en not_active IP Right Cessation
- 1991-07-22 ES ES91112237T patent/ES2121761T3/es not_active Expired - Lifetime
- 1991-07-22 SG SG1996006744A patent/SG48059A1/en unknown
- 1991-07-22 JP JP3181210A patent/JP2564714B2/ja not_active Expired - Fee Related
- 1991-07-22 PL PL29118591A patent/PL291185A1/xx unknown
- 1991-07-22 DK DK91112237T patent/DK0468401T3/da active
- 1991-07-22 CA CA002047531A patent/CA2047531C/en not_active Expired - Fee Related
- 1991-07-22 ZA ZA915723A patent/ZA915723B/xx unknown
- 1991-07-22 DE DE69130196T patent/DE69130196T2/de not_active Expired - Fee Related
- 1991-07-22 EP EP91112237A patent/EP0468401B1/en not_active Expired - Lifetime
- 1991-07-22 NO NO912866A patent/NO300132B1/no unknown
- 1991-07-22 CZ CS912281A patent/CZ283253B6/cs not_active IP Right Cessation
- 1991-07-22 AT AT91112237T patent/ATE171176T1/de not_active IP Right Cessation
- 1991-07-22 PT PT98413A patent/PT98413B/pt not_active IP Right Cessation
- 1991-07-23 KR KR1019910012579A patent/KR100201515B1/ko not_active Expired - Fee Related
- 1991-07-23 MX MX9100342A patent/MX9100342A/es not_active IP Right Cessation
-
1997
- 1997-04-13 BR BR1100534-3A patent/BR1100534A/pt active IP Right Grant
Also Published As
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| FI921641A0 (fi) | Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi | |
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