SG43036A1 - (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid - Google Patents

(S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid

Info

Publication number
SG43036A1
SG43036A1 SG1996002715A SG1996002715A SG43036A1 SG 43036 A1 SG43036 A1 SG 43036A1 SG 1996002715 A SG1996002715 A SG 1996002715A SG 1996002715 A SG1996002715 A SG 1996002715A SG 43036 A1 SG43036 A1 SG 43036A1
Authority
SG
Singapore
Prior art keywords
methyl
aminocarbony
buthyl
cid
piperidino
Prior art date
Application number
SG1996002715A
Other languages
English (en)
Inventor
Wolfgang Grell
Andreas Greischel
Gabriele Zahn
Michael Mark
Hansjorg Knorr
Eckhard Rupprecht
Ulrich Muller
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36781542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG43036(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA002111851A priority Critical patent/CA2111851C/en
Priority to PL91301997A priority patent/PL170210B1/pl
Priority to SG1996002715A priority patent/SG43036A1/en
Priority to AU80781/91A priority patent/AU660930B2/en
Priority claimed from CA002111851A external-priority patent/CA2111851C/en
Priority to PCT/EP1991/001147 priority patent/WO1993000337A1/de
Priority to SK1280-93A priority patent/SK281246B6/sk
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Priority to EP91911959A priority patent/EP0589874B1/de
Priority to JP3511056A priority patent/JP2921982B2/ja
Priority to CN91104984A priority patent/CN1048722C/zh
Priority to FI935724A priority patent/FI106027B/fi
Priority to NO934726A priority patent/NO303687B1/no
Publication of SG43036A1 publication Critical patent/SG43036A1/en
Priority to NO1999017C priority patent/NO1999017I1/no
Priority to GR990402743T priority patent/GR3031654T3/el
Priority to UY25923A priority patent/UY25923A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG1996002715A 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid SG43036A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SG1996002715A SG43036A1 (en) 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
JP3511056A JP2921982B2 (ja) 1991-06-21 1991-06-21 （ｓ）（＋）−２−エトキシ−４−［ｎ−［１−（２−ピペリジノ−フェニル）−３−メチル−１−ブチル〕アミノカルボニルメチル〕−安息香酸、この化合物を含む医薬組成物及びその調製方法
EP91911959A EP0589874B1 (de) 1991-06-21 1991-06-21 Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums
AU80781/91A AU660930B2 (en) 1991-06-21 1991-06-21 (S)(+)-2-ethoxy-4-(N-(1-(2-piperidinophenyl)-3-methyl-1- butyl)aminocarbonylmethyl)benzoic acid
PL91301997A PL170210B1 (pl) 1991-06-21 1991-06-21 Sposób wytwarzania nowego kwasu (S)(+)-2-etoksy-4-/N-/1-(2-piperydynofenylo)-3-metylo- 1-butyloaminokarbonylometylo/-benzoesowego i jego soli PL
PCT/EP1991/001147 WO1993000337A1 (de) 1991-06-21 1991-06-21 (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure
SK1280-93A SK281246B6 (sk) 1991-06-21 1991-06-21 Kyselina (s)(+)-2-etoxy-4-(n-(1-(2-piperidino-fenyl)-3-metyl-1- -butyl)-aminokarbonylmetyl)-benzoová, farmaceutické kompozície s jej obsahom, spôsob jej prípravy, medziprodukty na jej prípravu a jej použitie
CA002111851A CA2111851C (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
CN91104984A CN1048722C (zh) 1991-06-21 1991-07-22 (s)(+)-2-乙氧基-4-[n-[1-(2-哌啶子基-苯基)-3-甲基-1-丁基]氨基羰基甲基]苯甲酸,含该化合物的药物组合物及其制备方法
NO934726A NO303687B1 (no) 1991-06-21 1993-12-20 Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse (S)(+)-2-etoksy-4-[N-[1-(2-piperidino-fenyl)-3-metyl-1-butyl]aminokarbonylmetyl]-benzosyre
FI935724A FI106027B (fi) 1991-06-21 1993-12-20 Menetelmä (S)(+)-2-etoksi-4-[N-[1-(2-piperidinofenyyli)-3-metyyli-1-butyyli] aminokarbonyylimetyyli]-betsoehapon tai sen suolan valmistamiseksi sekä (S)-1-(2-piperidinofenyyli)-3-metyyli-1-butyyliamiinin N-asetyyli-L-glutamiinisuola sen valmistus
NO1999017C NO1999017I1 (no) 1991-06-21 1999-07-20 Repaglinid
GR990402743T GR3031654T3 (en) 1991-06-21 1999-10-27 Use of (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid for the preparation of a longlasting antidiabetic medicament
UY25923A UY25923A1 (es) 1991-06-21 2000-01-17 Composición farmacéutica para el tratamiento de diabetes mellitus.-

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/EP1991/001147 WO1993000337A1 (de) 1991-06-21 1991-06-21 (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure
SG1996002715A SG43036A1 (en) 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid
CA002111851A CA2111851C (en) 1991-06-21 1991-06-21 (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid
CN91104984A CN1048722C (zh) 1991-06-21 1991-07-22 (s)(+)-2-乙氧基-4-[n-[1-(2-哌啶子基-苯基)-3-甲基-1-丁基]氨基羰基甲基]苯甲酸,含该化合物的药物组合物及其制备方法

Publications (1)

Publication Number Publication Date
SG43036A1 true SG43036A1 (en) 1997-10-17

Family

ID=36781542

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996002715A SG43036A1 (en) 1991-06-21 1991-06-21 (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid

Country Status (8)

Country Link
EP (1) EP0589874B1 (de)
JP (1) JP2921982B2 (de)
CN (1) CN1048722C (de)
AU (1) AU660930B2 (de)
FI (1) FI106027B (de)
NO (2) NO303687B1 (de)
SG (1) SG43036A1 (de)
WO (1) WO1993000337A1 (de)

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PT1011673E (pt) 1997-06-13 2001-11-30 Novo Nordisk As Nova posologia para a dmni
IN192862B (de) 1999-11-16 2004-05-22 Ranbaxy Lab Ltd
PE20020617A1 (es) 2000-08-22 2002-08-05 Novartis Ag Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
EP1490090A4 (de) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
AU2003260078A1 (en) * 2002-08-23 2004-03-11 Dr. Reddy's Laboratories Limited Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof
EP1636199A2 (de) * 2003-05-14 2006-03-22 Cilag AG Verfahren zur herstellung von phenylessig derivaten
WO2004103983A1 (en) * 2003-05-26 2004-12-02 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives
WO2005021524A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Process for the preparation of amorphous form of repaglinide
CN1305863C (zh) * 2004-12-27 2007-03-21 浙江大学 (s)－异丙基－(2－哌啶)苯基－甲基胺的合成方法
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
FR2898894B1 (fr) * 2006-03-24 2008-06-06 Genfit Sa Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations
US7763607B2 (en) * 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
US7893080B2 (en) 2006-10-20 2011-02-22 Neurendo Pharma, Llc Method of restoring the incretin effect
US8101769B2 (en) 2007-02-15 2012-01-24 Actavis Group Ptc Ehf Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide
WO2009004485A2 (en) * 2007-06-06 2009-01-08 Actavis Group Ptc Ehf Repaglinide substantially free of dimer impurity
EP2019097A1 (de) 2007-07-25 2009-01-28 Aurobindo Pharma Limited Verfahren zur Herstellung von (alphaS)-alpha-(2-Methylpropyl)-2-(1-piperidinyl)benzenmethanamin
DE102008046995B4 (de) * 2008-09-12 2010-08-26 Stada Arzneimittel Ag 2-Ethoxy-benzoesäurederivat
EP2177221A1 (de) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Verfahren zur Erzeugung von weitgehend optisch reinem Repaglinid und seinen Vorläufern
AU2010247391A1 (en) 2009-05-15 2011-12-01 Novartis Ag Benzoxazolone derivatives as aldosterone synthase inhibitors
SG175925A1 (en) 2009-05-15 2011-12-29 Novartis Ag Aryl pyridine as aldosterone synthase inhibitors
UY32660A (es) 2009-05-28 2010-12-31 Novartis Ag Derivados aminobutricos sustituidos como inhibidores de neprilisina
MY156270A (en) 2009-05-28 2016-01-29 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
ES2663351T3 (es) 2009-11-17 2018-04-12 Novartis Ag Derivados de aril-piridina como inhibidores de la aldosterona sintasa
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
ES2472446T3 (es) 2009-11-30 2014-07-01 Novartis Ag Derivados de imidazol como inhibidores de aldosterona sintasa
EP2364977A1 (de) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Verfahren zur Enantiomerenanreicherung von 3-Methyl-1-(2-Piperidinphenyl)-1-Butylamin
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
CN102267959B (zh) * 2011-07-06 2013-05-01 海南锦瑞制药股份有限公司 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂
CN103012319B (zh) * 2011-09-20 2015-06-10 浙江九洲药业股份有限公司 瑞格列奈中间体的合成工艺改进
CN102584743A (zh) * 2011-12-28 2012-07-18 中国药科大学 对二甲氨基吡啶瑞格列奈共晶
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
MA38330B1 (fr) 2013-02-14 2016-09-30 Novartis Ag Dérivés d'acide phosphonique butanoïque de bisphénol substitués en qualité d'inhibiteurs de nep (endopeptidase neutre)
WO2015013169A2 (en) 2013-07-25 2015-01-29 Novartis Ag Bioconjugates of synthetic apelin polypeptides
WO2015013168A1 (en) 2013-07-25 2015-01-29 Novartis Ag Cyclic polypeptides for the treatment of heart failure
US10034871B2 (en) 2014-11-07 2018-07-31 Regents Of The University Of Minnesota Salts and compositions useful for treating disease
CA2972871A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
WO2018034627A1 (en) 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

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Also Published As

Publication number Publication date
JPH06508816A (ja) 1994-10-06
FI106027B (fi) 2000-11-15
JP2921982B2 (ja) 1999-07-19
FI935724A (fi) 1993-12-20
CN1048722C (zh) 2000-01-26
AU8078191A (en) 1993-01-25
FI935724A0 (fi) 1993-12-20
NO1999017I1 (no) 1999-07-20
CN1068820A (zh) 1993-02-10
NO934726D0 (no) 1993-12-20
EP0589874B1 (de) 1999-09-08
EP0589874A1 (de) 1994-04-06
NO934726L (no) 1993-12-20
AU660930B2 (en) 1995-07-13
NO303687B1 (no) 1998-08-17
WO1993000337A1 (de) 1993-01-07

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