SG174257A1 - Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases - Google Patents

Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases Download PDF

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Publication number
SG174257A1
SG174257A1 SG2011063914A SG2011063914A SG174257A1 SG 174257 A1 SG174257 A1 SG 174257A1 SG 2011063914 A SG2011063914 A SG 2011063914A SG 2011063914 A SG2011063914 A SG 2011063914A SG 174257 A1 SG174257 A1 SG 174257A1
Authority
SG
Singapore
Prior art keywords
compound
cancer
difluoro
pyrrolo
phenyl
Prior art date
Application number
SG2011063914A
Other languages
English (en)
Inventor
Prabha N Ibrahim
Wayne Spevak
Hanna Cho
Hongyao Zhu
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of SG174257A1 publication Critical patent/SG174257A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG2011063914A 2009-03-11 2010-03-10 Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases SG174257A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US15939609P 2009-03-11 2009-03-11
US15939009P 2009-03-11 2009-03-11
US15939209P 2009-03-11 2009-03-11
US15940609P 2009-03-11 2009-03-11
US15940009P 2009-03-11 2009-03-11
US15939509P 2009-03-11 2009-03-11
US15940209P 2009-03-11 2009-03-11
PCT/US2010/026816 WO2010104945A1 (en) 2009-03-11 2010-03-10 Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases

Publications (1)

Publication Number Publication Date
SG174257A1 true SG174257A1 (en) 2011-10-28

Family

ID=42199540

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2011063914A SG174257A1 (en) 2009-03-11 2010-03-10 Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases
SG10201402977WA SG10201402977WA (en) 2009-03-11 2010-03-10 Pyrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201402977WA SG10201402977WA (en) 2009-03-11 2010-03-10 Pyrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases

Country Status (23)

Country Link
US (1) US8901301B2 (no)
EP (1) EP2406259A1 (no)
JP (1) JP2012520307A (no)
KR (1) KR101663339B1 (no)
CN (1) CN102421776A (no)
AR (1) AR075812A1 (no)
AU (1) AU2010224245B2 (no)
BR (1) BRPI1011515A2 (no)
CA (1) CA2755045A1 (no)
CO (1) CO6620074A2 (no)
CR (1) CR20110476A (no)
EC (1) ECSP11011313A (no)
MA (1) MA33181B1 (no)
MX (1) MX2011009489A (no)
MY (1) MY161861A (no)
NI (1) NI201100168A (no)
NO (1) NO20111241A1 (no)
PE (1) PE20120184A1 (no)
RU (1) RU2011141123A (no)
SG (2) SG174257A1 (no)
TW (1) TW201036973A (no)
WO (1) WO2010104945A1 (no)
ZA (1) ZA201106599B (no)

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WO2009143018A2 (en) 2008-05-19 2009-11-26 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
JP2012509342A (ja) 2008-11-20 2012-04-19 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換ピロロ[2,3−b]−ピリジンおよび−ピラジン
AU2010232670B2 (en) 2009-04-03 2015-07-09 F. Hoffmann-La Roche Ag Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
PE20121327A1 (es) 2009-11-06 2012-10-18 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello
CA2781287C (en) 2009-11-18 2018-07-31 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
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US8771687B2 (en) 2010-12-02 2014-07-08 University of Pittsburgh—of the Commonwealth System of Higher Education Methods for treating a tumor using an antibody that specifically binds GRP94
PL2672967T3 (pl) * 2011-02-07 2019-04-30 Plexxikon Inc Związki i sposoby modulacji kinaz i wskazania ku temu
WO2012149547A1 (en) * 2011-04-28 2012-11-01 Duke University Methods of treating hemoglobinopathies
EP2709622A4 (en) 2011-05-17 2015-03-04 Plexxikon Inc CINEMA MODULATION AND INDICATIONS THEREFOR
US9988687B2 (en) * 2011-09-20 2018-06-05 The George Washington Univeristy Companion diagnostics for cancer and screening methods to identify companion diagnostics for cancer based on splicing variants
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US20130172375A1 (en) 2011-12-13 2013-07-04 Hoffmann-La Roche Inc. Pharmaceutical composition
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
MX367055B (es) 2012-06-26 2019-08-02 Del Mar Pharmaceuticals El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
TWI601725B (zh) 2012-08-27 2017-10-11 加拓科學公司 取代的氮雜吲哚化合物及其鹽、組合物和用途
AU2013312477B2 (en) 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2014081760A1 (en) 2012-11-20 2014-05-30 Duke University Methods of treating hemoglobinopathies
AR094263A1 (es) 2012-12-21 2015-07-22 Plexxikon Inc Compuestos moduladores selectivos de proteinquinasas
NZ630875A (en) 2013-03-15 2017-12-22 Plexxikon Inc Heterocyclic compounds and uses thereof
US20140303121A1 (en) 2013-03-15 2014-10-09 Plexxikon Inc. Heterocyclic compounds and uses thereof
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び/又は副作用を低減するための方法および組成物
BR112015028845A2 (pt) 2013-05-30 2017-07-25 Plexxikon Inc compostos para a modulação da quinase e indicações da mesma
EP3094736A4 (en) 2014-01-14 2017-10-25 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
US9771369B2 (en) 2014-03-04 2017-09-26 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
WO2016044067A1 (en) 2014-09-15 2016-03-24 Plexxikon Inc. Heterocyclic compounds and uses thereof
US20170248603A1 (en) 2014-10-06 2017-08-31 Dana-Farber Cancer Institute, Inc. Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response
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RS60731B1 (sr) 2015-05-06 2020-09-30 Plexxikon Inc Čvrsti oblici jedinjenja koje modulira kinaze
KR102637844B1 (ko) 2015-05-06 2024-02-19 다이이치 산쿄 인코포레이티드 키나아제를 조절하는 1h-피롤로[2,3­b]피리딘 유도체의 합성
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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AU2017232610B2 (en) 2016-03-16 2021-07-22 Plexxikon Inc. Compounds and methods for kinase modulation and indications therefore
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PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA

Also Published As

Publication number Publication date
ZA201106599B (en) 2014-02-26
PE20120184A1 (es) 2012-03-28
TW201036973A (en) 2010-10-16
SG10201402977WA (en) 2014-09-26
MY161861A (en) 2017-05-15
US20100286178A1 (en) 2010-11-11
AU2010224245B2 (en) 2016-07-21
CA2755045A1 (en) 2010-09-16
CN102421776A (zh) 2012-04-18
NO20111241A1 (no) 2011-09-28
AR075812A1 (es) 2011-04-27
US8901301B2 (en) 2014-12-02
BRPI1011515A2 (pt) 2016-03-29
NI201100168A (es) 2012-01-11
RU2011141123A (ru) 2013-04-20
KR101663339B1 (ko) 2016-10-06
WO2010104945A1 (en) 2010-09-16
EP2406259A1 (en) 2012-01-18
ECSP11011313A (es) 2011-10-31
JP2012520307A (ja) 2012-09-06
KR20110125670A (ko) 2011-11-21
MA33181B1 (fr) 2012-04-02
CO6620074A2 (es) 2013-02-15
MX2011009489A (es) 2011-10-11
AU2010224245A1 (en) 2011-09-29
CR20110476A (es) 2012-01-04

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