SG151294A1 - Receptor coupling agents and therapeutic uses thereof - Google Patents
Receptor coupling agents and therapeutic uses thereofInfo
- Publication number
- SG151294A1 SG151294A1 SG200901965-4A SG2009019654A SG151294A1 SG 151294 A1 SG151294 A1 SG 151294A1 SG 2009019654 A SG2009019654 A SG 2009019654A SG 151294 A1 SG151294 A1 SG 151294A1
- Authority
- SG
- Singapore
- Prior art keywords
- coupling agents
- therapeutic uses
- receptor coupling
- receptor
- subject
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55580504P | 2004-03-23 | 2004-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG151294A1 true SG151294A1 (en) | 2009-04-30 |
Family
ID=34968432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200901965-4A SG151294A1 (en) | 2004-03-23 | 2005-03-23 | Receptor coupling agents and therapeutic uses thereof |
Country Status (12)
Country | Link |
---|---|
US (2) | US7799902B2 (de) |
EP (2) | EP1756162A1 (de) |
JP (1) | JP2007530588A (de) |
KR (1) | KR20060132006A (de) |
CN (1) | CN1980957A (de) |
AU (1) | AU2005227322A1 (de) |
BR (1) | BRPI0509201A (de) |
CA (1) | CA2560742A1 (de) |
IL (1) | IL178254A0 (de) |
NZ (1) | NZ550518A (de) |
SG (1) | SG151294A1 (de) |
WO (1) | WO2005092927A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6312691B1 (en) * | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
TW200416044A (en) * | 2002-07-01 | 2004-09-01 | Biogen Inc | Humanized anti-lymphotoxin β receptor antibodies |
AU2003303339A1 (en) * | 2002-12-20 | 2004-07-22 | Biogen Idec Ma Inc. | Lymphotoxin beta receptor agents in combination with chemotherapeutic agents |
WO2005000898A2 (en) | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
AU2005227322A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
JP5374359B2 (ja) * | 2006-03-17 | 2013-12-25 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 安定化されたポリペプチド化合物 |
US8338376B2 (en) * | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
KR20090071652A (ko) * | 2006-10-20 | 2009-07-01 | 바이오겐 아이덱 엠에이 인코포레이티드 | 가용성 림프독소-베타-수용체를 이용한 탈수초성 장애의 치료 |
AU2010303142B2 (en) * | 2009-09-29 | 2013-05-09 | Roche Glycart Ag | Bispecific death receptor agonistic antibodies |
EP2517555A4 (de) | 2009-12-25 | 2014-09-24 | Chugai Pharmaceutical Co Ltd | Such- und screening-verfahren für ein zielmolekül eines krebsmittels mit einem nichtmenschlichen tiermodell mit darin transplantierter nog-krebszelllinie |
EP2626414B1 (de) | 2010-10-06 | 2020-07-15 | Chugai Seiyaku Kabushiki Kaisha | Krebsstammzellenmasse und verfahren zu ihrer herstellung |
EP4303236A3 (de) | 2010-11-30 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | Zytotoxizitätsinduzierendes therapeutikum |
JP6077997B2 (ja) | 2011-09-07 | 2017-02-08 | 中外製薬株式会社 | 癌幹細胞の分離 |
CA2850549C (en) | 2011-09-30 | 2023-03-14 | Teva Pharmaceuticals Australia Pty Ltd. | Antibodies against tl1a and uses thereof |
WO2013062083A1 (ja) | 2011-10-28 | 2013-05-02 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞特異的分子 |
US9872982B2 (en) * | 2012-01-10 | 2018-01-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Electroosmotic convection-enhanced delivery system |
US20140004131A1 (en) * | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
CA2943943C (en) * | 2014-04-07 | 2023-01-10 | Chugai Seiyaku Kabushiki Kaisha | Immunoactivating antigen-binding molecule |
WO2015172305A1 (zh) * | 2014-05-12 | 2015-11-19 | 上海康岱生物医药技术股份有限公司 | 抑制taci-baff复合物形成的融合蛋白及其制法和用途 |
SG11201609370QA (en) | 2014-05-13 | 2016-12-29 | Chugai Pharmaceutical Co Ltd | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
SG11201609721WA (en) | 2014-05-28 | 2016-12-29 | Agenus Inc | Anti-gitr antibodies and methods of use thereof |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
EP3359576A4 (de) | 2015-10-08 | 2019-08-28 | Zymeworks Inc. | Antigenbindende polypeptidkonstrukte mit kappa- und lambda-leichtketten und verwendungen davon |
US11649293B2 (en) | 2015-11-18 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for enhancing humoral immune response |
US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
IL299072A (en) | 2015-12-02 | 2023-02-01 | Memorial Sloan Kettering Cancer Center | Antibodies and methods for using them |
BR112019000512A2 (pt) | 2016-07-14 | 2019-04-24 | Genmab A/S | anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit |
RU2019142330A (ru) | 2017-06-30 | 2021-07-30 | Займворкс, Инк. | Стабилизированные химерные fab |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
AU2019297451A1 (en) | 2018-07-03 | 2021-01-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
KR20220130687A (ko) * | 2019-12-11 | 2022-09-27 | 시락 게엠베하 인터내셔날 | Ltbr 및 edb 결합 도메인을 포함하는 다중특이성 결합 분자 및 이의 용도 |
WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
CA3214757A1 (en) | 2021-04-08 | 2022-10-13 | Andreas Loew | Multifuntional molecules binding to tcr and uses thereof |
Family Cites Families (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US341393A (en) | 1886-05-04 | Steam-pump | ||
US3773319A (en) | 1971-12-16 | 1973-11-20 | Fabcor Ind Inc | Corrugated sheet inverting machine |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
NZ212207A (en) | 1984-05-31 | 1991-07-26 | Genentech Inc | Recombinant lymphotoxin |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (de) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimäre Rezeptoren durch Verbindung und Expression von DNS |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
GB8529014D0 (en) * | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
EP0328699B1 (de) | 1988-02-16 | 1991-09-18 | Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg | Spritze für medizinische Zwecke |
ATE135370T1 (de) | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
EP0440846B1 (de) | 1990-02-07 | 1993-06-09 | Arzneimittel GmbH Apotheker Vetter & Co. Ravensburg | Doppelkammerspritze und Verwendungsverfahren |
DE69132629T2 (de) * | 1990-06-27 | 2002-04-18 | Biogen, Inc. | Oberflächenkomplexbildung von lymphotoxin |
US5670149A (en) * | 1990-06-27 | 1997-09-23 | Biogen, Inc. | Lymphotoxin-β, Lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
US7030080B2 (en) * | 1990-06-27 | 2006-04-18 | Biogen, Inc. | Lymphotoxin-β, lymphotoxin-β complexes, pharmaceutical preparations and therapeutic uses thereof |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5874082A (en) | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
EP0672143B1 (de) | 1992-12-04 | 2008-06-04 | Biogen Idec MA Inc. | Lymphotoxin-beta, lymphotoxin-beta komplexe, pharmazeutische zubereitungen und therapeutische verwendungen davon |
IL108776A (en) * | 1993-03-11 | 1999-11-30 | Genentech Inc | A method of dissolving a cell or inhibiting cell growth, a bispecific molecule that binds FNT-1R and an SAF antibody, a medical preparation that contains it and its use |
DK0724456T3 (da) | 1993-10-01 | 2004-04-13 | Immunex Corp | CD40-Antistoffer |
US5620889A (en) | 1993-10-14 | 1997-04-15 | Immunex Corporation | Human anti-Fas IgG1 monoclonal antibodies |
US5985547A (en) | 1994-03-04 | 1999-11-16 | Children's Hospital Of Philadelphia | Detection of a mutation in the HLA-DMβ gene in an immunocompromised patient |
CA2211443A1 (en) | 1995-01-26 | 1996-08-01 | Biogen, Inc. | Lymphotoxin-.alpha./.beta. complexes and anti-lymphotoxin-beta receptor antibodies as anti-tumor agents |
US6312691B1 (en) * | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
US6284236B1 (en) | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
EP0835305B1 (de) | 1995-06-29 | 2005-11-23 | Immunex Corporation | Apoptosis induzierendes cytokin |
US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
EP0882051B1 (de) | 1996-02-07 | 2001-11-07 | Janssen Pharmaceutica N.V. | Thiophenopyrimidine |
US6462176B1 (en) | 1996-09-23 | 2002-10-08 | Genentech, Inc. | Apo-3 polypeptide |
NZ334691A (en) | 1996-10-11 | 2000-12-22 | Bristol Myers Squibb Co | Compositions of anti-4-1BB antibody effective for immunomodulation and treatment of T-cell autoimmune disease |
US7255854B1 (en) * | 1996-10-25 | 2007-08-14 | Biogen, Inc. | Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
DE69740107D1 (de) | 1996-12-23 | 2011-03-10 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
NZ337795A (en) | 1997-03-17 | 2001-06-29 | Human Genome Sciences Inc | Death domain containing receptor 5 and it's use in the treatment of DR5 related disease |
US20050233958A1 (en) | 1997-03-17 | 2005-10-20 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US20040136951A1 (en) | 1997-03-17 | 2004-07-15 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
ATE516354T1 (de) | 1997-05-15 | 2011-07-15 | Genentech Inc | Apo-2-rezeptor |
US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
AU8400398A (en) | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
US6417328B2 (en) | 1997-08-15 | 2002-07-09 | Thomas Jefferson Univeristy | Trail receptors, nucleic acids encoding the same, and methods of use thereof |
AU738688B2 (en) | 1997-09-12 | 2001-09-27 | Apoxis Sa | Cysteine rich receptors-train |
PT1051187E (pt) | 1998-01-30 | 2004-03-31 | Biogen Inc | Tratamento de linfomas foliculares usando inibidores da via da linfotoxina (lt) |
US7060667B1 (en) * | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
US6437113B1 (en) | 1998-03-05 | 2002-08-20 | Tularik Inc. | Suppressors of death domains |
GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
US6252050B1 (en) | 1998-06-12 | 2001-06-26 | Genentech, Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
AU4561199A (en) | 1998-06-12 | 1999-12-30 | Genentech Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
US6355782B1 (en) | 1998-07-09 | 2002-03-12 | Baylor College Of Medicine | Hypohidrotic ectodermal dyplasia genes and proteins |
CN1200733C (zh) * | 1998-10-09 | 2005-05-11 | 拜奥根有限公司 | 阻断淋巴毒素β与其受体结合的物质在制备药物中的应用 |
AU2021800A (en) | 1998-12-04 | 2000-06-26 | Schering Corporation | Mammalian genes; related reagents |
JP2002543151A (ja) | 1999-05-04 | 2002-12-17 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 死ドメイン含有レセプター5 |
US20030118588A1 (en) | 1999-05-22 | 2003-06-26 | Linda Diehl | Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40 |
CA2375149A1 (en) | 1999-06-09 | 2000-12-14 | Genentech, Inc. | Apo-2l receptor agonist and cpt-11 synergism |
EP1226161A2 (de) | 1999-09-15 | 2002-07-31 | Genentech, Inc. | Apo-2 rezeptor antikörper |
US6727225B2 (en) | 1999-12-20 | 2004-04-27 | Immunex Corporation | TWEAK receptor |
EP1272647B1 (de) | 2000-04-11 | 2014-11-12 | Genentech, Inc. | Multivalente antikörper und deren verwendung |
US20030059427A1 (en) | 2000-04-28 | 2003-03-27 | Force Walker R. | Isolation and characterization of highly active anti-CD40 antibody |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
DE10034607A1 (de) * | 2000-07-20 | 2002-02-07 | Gundram Jung | Multispezifisches Reagenz zur selektiven Stimulierung von Zelloberflächenrezeptoren |
IL153948A0 (en) | 2000-07-27 | 2003-07-31 | Genentech Inc | Apo-2l receptor agonist and cpt-11 synergism |
US20040005314A1 (en) | 2001-07-27 | 2004-01-08 | Enrique Escandon | Apo-2l receptor agonist and cpt-11 synergism |
AU2001289019B2 (en) | 2000-09-14 | 2006-07-27 | Biogen Idec Ma Inc. | Tweak receptor agonists as anti-angiogenic agents |
CN1547590A (zh) | 2000-10-13 | 2004-11-17 | ¸ | 人源化抗-LT-β-R抗体 |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
CA2438682A1 (en) * | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
US20020155109A1 (en) * | 2001-04-20 | 2002-10-24 | Lynch David H. | Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2 |
CA2447602C (en) | 2001-05-18 | 2011-11-01 | Kirin Beer Kabushiki Kaisha | Anti-trail-r antibodies |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US7662374B2 (en) * | 2001-08-03 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies to activated erbB family members and methods of use thereof |
EP2348043A1 (de) | 2001-10-02 | 2011-07-27 | Genentech, Inc. | APO-2-Ligandvarianten und Verwendungen dafür |
JP2005522986A (ja) | 2001-10-19 | 2005-08-04 | ジェネンテック・インコーポレーテッド | 炎症性腸疾患の診断と治療のための組成物と方法 |
ES2357225T3 (es) | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
CA2467242A1 (en) | 2001-11-20 | 2003-05-30 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
WO2003080671A1 (en) | 2002-03-21 | 2003-10-02 | Komed Co., Ltd. | Anti-rank monoclonal antibodies and pharmaceutical composition containing the same |
WO2004000238A2 (en) | 2002-03-22 | 2003-12-31 | Tittle Thomas V | Utilization of mhc class ii binding motifs in immunization to produce immune serum, monoclonal antibodies and vaccines |
AU2003228483A1 (en) | 2002-04-12 | 2003-10-27 | Human Genome Sciences, Inc. | Antibodies that specifically bind to tr2 |
US20040101915A1 (en) | 2002-06-18 | 2004-05-27 | Irm Llc, A Delaware Limited Liability Company | Diagnosis and treatment of chemoresistant tumors |
EP2500032A1 (de) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2-Liganden-/Trailvarianten und Verwendungen dafür |
US6889341B2 (en) | 2002-06-28 | 2005-05-03 | Hewlett-Packard Development Company, L.P. | Method and apparatus for maintaining data integrity using a system management processor |
TW200416044A (en) | 2002-07-01 | 2004-09-01 | Biogen Inc | Humanized anti-lymphotoxin β receptor antibodies |
DE60334247D1 (de) | 2002-11-27 | 2010-10-28 | Irm Llc | Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen |
EP1583503A4 (de) | 2002-12-20 | 2006-08-09 | Biogen Idec Inc | Polyvalente lymphotoxin-beta-rezeptor-agonisten und therapeutische verwendung dafür |
AU2003303339A1 (en) | 2002-12-20 | 2004-07-22 | Biogen Idec Ma Inc. | Lymphotoxin beta receptor agents in combination with chemotherapeutic agents |
DE602004019701D1 (de) | 2003-05-09 | 2009-04-09 | Genentech Inc | Peptide welche an Apo2L (Trail) Rezeptoren binden und Verwendungen davon |
CA2534639C (en) | 2003-07-31 | 2013-07-30 | Immunomedics, Inc. | Anti-cd19 antibodies |
CA2534898A1 (en) | 2003-08-08 | 2005-02-17 | Immunomedics, Inc. | Bispecific antibodies for inducing apoptosis of tumor and diseased cells |
AU2005227322A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
JP4829780B2 (ja) | 2004-03-26 | 2011-12-07 | 武田薬品工業株式会社 | 呼吸器疾患の予防・治療剤 |
KR20070010046A (ko) | 2004-04-06 | 2007-01-19 | 제넨테크, 인크. | Dr5 항체 및 그의 용도 |
WO2005123141A2 (en) | 2004-06-11 | 2005-12-29 | Board Of Regents, The University Of Texas System | Combination treatment of cancer with elicitor of gene product expression and gene-product targeting agent |
KR20070050911A (ko) | 2004-06-18 | 2007-05-16 | 제넨테크, 인크. | Apo2l 수용체 작동제 및 nk 세포 활성화제의 사용방법 |
RU2431676C2 (ru) | 2004-08-06 | 2011-10-20 | Дженентек, Инк. | Анализы и способы с применением биомаркеров |
EP2292794A3 (de) | 2004-08-06 | 2011-07-06 | Genentech, Inc. | DR Antikörper zur pharmazeutischen Verwendung und Verfahren zur Vorhersage der Sensitivität von Zellen gegenüber solchen Antikörpern mittels Biomarkern |
CN100427505C (zh) | 2004-08-19 | 2008-10-22 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体(ad5-10)及其制法与用途 |
BRPI0515615A (pt) | 2004-09-08 | 2008-07-29 | Genentech Inc | métodos para tratar células cancerosas e doença imune relacionada |
EP1802660A2 (de) | 2004-09-08 | 2007-07-04 | Genentech, Inc. | Verfahren zur verwendung von todesrezeptorliganden und cd20-antikörpern |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
US20060188498A1 (en) | 2005-02-18 | 2006-08-24 | Genentech, Inc. | Methods of using death receptor agonists and EGFR inhibitors |
IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
-
2005
- 2005-03-23 AU AU2005227322A patent/AU2005227322A1/en not_active Abandoned
- 2005-03-23 CN CNA2005800165978A patent/CN1980957A/zh active Pending
- 2005-03-23 WO PCT/US2005/009967 patent/WO2005092927A1/en active Application Filing
- 2005-03-23 JP JP2007505213A patent/JP2007530588A/ja active Pending
- 2005-03-23 EP EP05744495A patent/EP1756162A1/de not_active Withdrawn
- 2005-03-23 EP EP10186088A patent/EP2332992A1/de not_active Withdrawn
- 2005-03-23 BR BRPI0509201-9A patent/BRPI0509201A/pt not_active IP Right Cessation
- 2005-03-23 KR KR1020067021701A patent/KR20060132006A/ko not_active Application Discontinuation
- 2005-03-23 NZ NZ550518A patent/NZ550518A/en unknown
- 2005-03-23 CA CA002560742A patent/CA2560742A1/en not_active Abandoned
- 2005-03-23 SG SG200901965-4A patent/SG151294A1/en unknown
-
2006
- 2006-09-21 IL IL178254A patent/IL178254A0/en unknown
- 2006-09-21 US US11/524,786 patent/US7799902B2/en active Active
-
2010
- 2010-01-26 US US12/694,092 patent/US7947271B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US7799902B2 (en) | 2010-09-21 |
IL178254A0 (en) | 2006-12-31 |
EP2332992A1 (de) | 2011-06-15 |
US7947271B2 (en) | 2011-05-24 |
BRPI0509201A (pt) | 2007-08-28 |
WO2005092927A1 (en) | 2005-10-06 |
AU2005227322A1 (en) | 2005-10-06 |
JP2007530588A (ja) | 2007-11-01 |
US20100266542A1 (en) | 2010-10-21 |
NZ550518A (en) | 2009-11-27 |
KR20060132006A (ko) | 2006-12-20 |
CA2560742A1 (en) | 2005-10-06 |
EP1756162A1 (de) | 2007-02-28 |
US20070154476A1 (en) | 2007-07-05 |
CN1980957A (zh) | 2007-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG151294A1 (en) | Receptor coupling agents and therapeutic uses thereof | |
WO2004058191A3 (en) | Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof | |
DK1689846T3 (da) | Konjugater af maytansinoid DM1 med antistof trastuzumab, bundet via en ikke-spaltelig linker, og anvendelse heraf i tumorbehandling | |
EP1718145A4 (de) | Konjugate für die krebstherapie und -diagnose | |
SG160412A1 (en) | Anti-igfr1 antibody therapeutic combinations | |
ZA200709780B (en) | Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues | |
EP1827489A4 (de) | Verwendung von flagellin zur tumorimmuntherapie | |
HK1206617A1 (en) | Methods for treating cancer using an immunotoxin | |
EP1749095A4 (de) | Neue therapeutische targets für karzinome | |
EP1967209A4 (de) | Therapeutisches mittel gegen prostatakrebs | |
MX2009006779A (es) | Antagonistas especificos para terapia con adyuvantes y neo-adyuvantes y el tratamiento de tumores en etapa temprana. | |
IL188588A0 (en) | Anti-ctla -4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment | |
WO2008054585A3 (en) | Use of pegylated il-10 to treat cancer | |
HK1081448A1 (en) | Bispecific anti-erb-b antibodies and their use in tumor therapy | |
MX2007014132A (es) | Compuestos de diarilhidantoina. | |
WO2008136869A3 (en) | Methods and compositions related to targeting wounds, regenerating tissue, and tumors | |
ZA200703699B (en) | Nitrobenzindoles and their use in cancer therapy | |
IL180256A0 (en) | Pyrido-pyrido pyrimidine derivatives, preparation thereof, therapeutic use thereof for treating cancer | |
EP1756166A4 (de) | Diagnose und behandlung von prostatakrebs | |
EP1793678A4 (de) | Tumorbehandlung durch injektion von dendritischen zellen | |
AU2003302165A8 (en) | Prostate specific antigens, conjugates thereof, methods for their preparation and uses thereof. | |
AP2007004024A0 (en) | Therapeutic pyrazoloÄ3,4-BÜpyridines and indazoles | |
WO2006105255A3 (en) | Cancer vaccines and therapeutic methods | |
EP1782827A4 (de) | Peptid-vakzine für die krebstherapie | |
EP1778873A4 (de) | Neue therapeutische targets für karzinome |