SG147471A1 - Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime - Google Patents

Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime

Info

Publication number
SG147471A1
SG147471A1 SG200807957-6A SG2008079576A SG147471A1 SG 147471 A1 SG147471 A1 SG 147471A1 SG 2008079576 A SG2008079576 A SG 2008079576A SG 147471 A1 SG147471 A1 SG 147471A1
Authority
SG
Singapore
Prior art keywords
fluorescence lifetime
test systems
biological test
direct observation
measuring fluorescence
Prior art date
Application number
SG200807957-6A
Other languages
English (en)
Inventor
Franz-Josef Meyer-Almes
Gabriele Wirtz
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2003148949 external-priority patent/DE10348949A1/de
Priority claimed from DE200410022107 external-priority patent/DE102004022107A1/de
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of SG147471A1 publication Critical patent/SG147471A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG200807957-6A 2003-10-18 2004-10-05 Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime SG147471A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003148949 DE10348949A1 (de) 2003-10-18 2003-10-18 Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer
DE200410022107 DE102004022107A1 (de) 2004-05-05 2004-05-05 Direkte Beobachtung molekularer Veränderungen in biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer

Publications (1)

Publication Number Publication Date
SG147471A1 true SG147471A1 (en) 2008-11-28

Family

ID=34553309

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200807957-6A SG147471A1 (en) 2003-10-18 2004-10-05 Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime

Country Status (7)

Country Link
US (1) US20070042500A1 (ja)
EP (1) EP1678483A1 (ja)
JP (1) JP2007509317A (ja)
KR (1) KR20060105747A (ja)
CA (1) CA2542774A1 (ja)
SG (1) SG147471A1 (ja)
WO (1) WO2005043137A1 (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010505126A (ja) * 2006-09-29 2010-02-18 グラクソ グループ リミテッド 高速相発光分光分析のための方法およびシステム
GB0712109D0 (en) * 2007-06-22 2007-08-01 Edinburgh Instr Fluorescence lifetime and fluorescence assays
WO2016022998A2 (en) 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device for temporal binning of received photons
TWI734748B (zh) 2016-02-17 2021-08-01 美商太斯萊特健康股份有限公司 用於生命期成像及偵測應用之感測器及裝置
US10845308B2 (en) 2016-12-22 2020-11-24 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
AU2019288394A1 (en) 2018-06-22 2021-01-07 Quantum-Si Incorporated Integrated photodetector with charge storage bin of varied detection time
CN113786170B (zh) * 2021-09-18 2024-05-31 暨南大学附属第一医院（广州华侨医院） 基于超光谱成像的肿瘤成像方法、装置、设备及存储介质

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2061387B1 (es) * 1992-12-30 1995-07-01 Univ Oviedo Sensor optico de oxigeno basado en complejos fosforescentes metal-ferron.
US20010004522A1 (en) * 1997-10-28 2001-06-21 Thomas J. Burke Kinase activity measurement using fluorescence polarization
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
DE19925402C2 (de) * 1999-06-02 2001-12-20 Molecular Machines & Ind Gmbh Screening von Target-Ligand-Wechselwirkungen
US6690463B2 (en) * 2000-02-10 2004-02-10 Evotec Biosystems Ag Fluorescence intensity and lifetime distribution analysis
US20030129649A1 (en) * 2001-04-24 2003-07-10 Kobilka Brian K. Conformational assays to detect binding to G protein-coupled receptors
GB0208987D0 (en) * 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring protein kinase and phosphatase activity
DE502004006979D1 (de) * 2003-04-10 2008-06-12 Tecan Trading Ag Verfahren zum Messen von an biologische Moleküle gebundenen, chemischen Gruppen

Also Published As

Publication number Publication date
KR20060105747A (ko) 2006-10-11
EP1678483A1 (de) 2006-07-12
US20070042500A1 (en) 2007-02-22
JP2007509317A (ja) 2007-04-12
WO2005043137A1 (de) 2005-05-12
CA2542774A1 (en) 2005-05-12

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