SG145759A1 - Acyloxyalkyl carbamate prodrugs, methods of synthesis and use - Google Patents
Acyloxyalkyl carbamate prodrugs, methods of synthesis and useInfo
- Publication number
- SG145759A1 SG145759A1 SG200806169-9A SG2008061699A SG145759A1 SG 145759 A1 SG145759 A1 SG 145759A1 SG 2008061699 A SG2008061699 A SG 2008061699A SG 145759 A1 SG145759 A1 SG 145759A1
- Authority
- SG
- Singapore
- Prior art keywords
- synthesis
- methods
- carbamate prodrugs
- acyloxyalkyl carbamate
- acyloxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49693803P | 2003-08-20 | 2003-08-20 | |
| US60663704P | 2004-08-13 | 2004-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG145759A1 true SG145759A1 (en) | 2008-09-29 |
Family
ID=36762986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200806169-9A SG145759A1 (en) | 2003-08-20 | 2004-08-20 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1660440B1 (ru) |
| JP (3) | JP5148874B2 (ru) |
| CN (2) | CN101914040A (ru) |
| AT (1) | ATE546427T1 (ru) |
| CA (1) | CA2536257C (ru) |
| CY (1) | CY1112827T1 (ru) |
| ES (1) | ES2382000T3 (ru) |
| HK (1) | HK1090912A1 (ru) |
| IL (1) | IL173826A (ru) |
| NO (1) | NO335606B1 (ru) |
| NZ (1) | NZ545719A (ru) |
| PL (1) | PL1660440T3 (ru) |
| RU (2) | RU2423347C2 (ru) |
| SG (1) | SG145759A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG145759A1 (en) * | 2003-08-20 | 2008-09-29 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| CA2706575C (en) * | 2008-01-25 | 2015-07-14 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
| JP6925080B2 (ja) * | 2017-08-25 | 2021-08-25 | ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司Ｇｕａｎｇｚｈｏｕ Ｈｅｎｏｖｃｏｍ Ｂｉｏｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ | 長時間作用型ラサギリンプロドラッグ、その製造方法および用途 |
| CN107805202A (zh) * | 2017-12-01 | 2018-03-16 | 内蒙古圣氏化学股份有限公司 | 一种氯甲基异丙基碳酸酯连续化反应装置及方法 |
| CN117623989A (zh) * | 2022-08-29 | 2024-03-01 | 广州市恒诺康医药科技有限公司 | 一种mao-b抑制剂前药的多晶型及其制备方法和用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3475065D1 (en) * | 1983-06-23 | 1988-12-15 | Merck & Co Inc | (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives |
| GB2365425A (en) * | 2000-08-01 | 2002-02-20 | Parke Davis & Co Ltd | Alkyl amino acid derivatives useful as pharmaceutical agents |
| AU2002345664C1 (en) * | 2001-06-11 | 2008-03-06 | Xenoport, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
| SG145759A1 (en) * | 2003-08-20 | 2008-09-29 | Xenoport Inc | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
-
2004
- 2004-08-20 SG SG200806169-9A patent/SG145759A1/en unknown
- 2004-08-20 EP EP04781926A patent/EP1660440B1/en not_active Expired - Lifetime
- 2004-08-20 RU RU2006108541/04A patent/RU2423347C2/ru not_active IP Right Cessation
- 2004-08-20 CA CA2536257A patent/CA2536257C/en not_active Expired - Fee Related
- 2004-08-20 CN CN201010221620XA patent/CN101914040A/zh active Pending
- 2004-08-20 ES ES04781926T patent/ES2382000T3/es not_active Expired - Lifetime
- 2004-08-20 NZ NZ545719A patent/NZ545719A/en not_active IP Right Cessation
- 2004-08-20 AT AT04781926T patent/ATE546427T1/de active
- 2004-08-20 PL PL04781926T patent/PL1660440T3/pl unknown
- 2004-08-20 JP JP2006524109A patent/JP5148874B2/ja not_active Expired - Fee Related
- 2004-08-20 CN CN2004800283518A patent/CN1860101B/zh not_active Expired - Fee Related
-
2006
- 2006-02-20 IL IL173826A patent/IL173826A/en active IP Right Grant
- 2006-03-20 NO NO20061268A patent/NO335606B1/no not_active IP Right Cessation
- 2006-11-17 HK HK06112680.4A patent/HK1090912A1/xx not_active IP Right Cessation
-
2010
- 2010-11-23 RU RU2010147826/04A patent/RU2010147826A/ru not_active Application Discontinuation
-
2011
- 2011-07-25 JP JP2011162504A patent/JP2011256182A/ja active Pending
-
2012
- 2012-05-02 CY CY20121100410T patent/CY1112827T1/el unknown
- 2012-08-03 JP JP2012173119A patent/JP2013006842A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1660440A2 (en) | 2006-05-31 |
| CA2536257A1 (en) | 2005-03-03 |
| CY1112827T1 (el) | 2016-02-10 |
| IL173826A (en) | 2014-07-31 |
| RU2423347C2 (ru) | 2011-07-10 |
| JP2011256182A (ja) | 2011-12-22 |
| CN1860101A (zh) | 2006-11-08 |
| ATE546427T1 (de) | 2012-03-15 |
| EP1660440B1 (en) | 2012-02-22 |
| HK1090912A1 (en) | 2007-01-05 |
| NO20061268L (no) | 2006-05-22 |
| CA2536257C (en) | 2012-01-03 |
| JP2013006842A (ja) | 2013-01-10 |
| CN1860101B (zh) | 2010-10-27 |
| JP2007521318A (ja) | 2007-08-02 |
| CN101914040A (zh) | 2010-12-15 |
| RU2010147826A (ru) | 2012-05-27 |
| RU2006108541A (ru) | 2007-09-27 |
| ES2382000T3 (es) | 2012-06-04 |
| NO335606B1 (no) | 2015-01-12 |
| PL1660440T3 (pl) | 2012-07-31 |
| NZ545719A (en) | 2010-03-26 |
| IL173826A0 (en) | 2006-07-05 |
| JP5148874B2 (ja) | 2013-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1660440E (pt) | Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização | |
| IL176341A0 (en) | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | |
| AU2003291668A8 (en) | Sacrificial compositions, methods of use thereof, and methods of decomposition thereof | |
| AU2003285934A8 (en) | Analogs and prodrugs of buprenorphine | |
| SG147409A1 (en) | Amide derivatives | |
| PL1646634T3 (pl) | Zastosowanie rapamycyny i pochodnych rapamycyny w leczeniu utraty kości | |
| MXPA06000123A (es) | Suspension aislante de apoyo central de resorte rapido de plastico y metodo para fabricar y ensamblar el mismo. | |
| AU154703S (en) | Set of trocars | |
| GB2388056B (en) | Synthesis of polyisoprene with neodymium catalyst | |
| AU2003285200A8 (en) | Modified carbamate-containing prodrugs and methods of synthesizing same | |
| TW200634023A (en) | Amide prodrug of gemcitabine, compositions and use thereof | |
| TW200744567A (en) | Phenylethylamine analogs and their use for treating glaucoma | |
| IL223579A0 (en) | Synthesis of amines and intermediates for the synthesis thereof | |
| MX2007002277A (es) | Metodos para formar retinoides y usos de los mismos. | |
| TW200508233A (en) | Chk-1 inhibitors | |
| HRP20040920A2 (en) | Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine | |
| SG145759A1 (en) | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | |
| SG144920A1 (en) | Method and intermediates for the preparation of derivatives of n-(1- benzhydrylazetidin-3-yl)-n-phenylmethylsulphonamide | |
| SG140447A1 (en) | Method of forming a micro-rotating device, and a micro-rotating device produced by the method | |
| TW200510276A (en) | Calcilytic compounds | |
| AU2003256672A8 (en) | Modulators of leukocyte activation, bic compositions and methods of use | |
| MXPA02004180A (es) | Metodos de sintesis de dl-hidroxi-alquil-fenil amidas. | |
| AU2003239985A8 (en) | High voltage-wide band amplifier | |
| ZA200601697B (en) | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | |
| EP1735848A4 (en) | SYSTEMS AND METHOD FOR LOCATED AUDIOSYNTHESIS |