SG145759A1 - Acyloxyalkyl carbamate prodrugs, methods of synthesis and use - Google Patents

Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Info

Publication number
SG145759A1
SG145759A1 SG200806169-9A SG2008061699A SG145759A1 SG 145759 A1 SG145759 A1 SG 145759A1 SG 2008061699 A SG2008061699 A SG 2008061699A SG 145759 A1 SG145759 A1 SG 145759A1
Authority
SG
Singapore
Prior art keywords
synthesis
methods
carbamate prodrugs
acyloxyalkyl carbamate
acyloxyalkyl
Prior art date
Application number
SG200806169-9A
Other languages
English (en)
Inventor
Mark A Gallop
Fenmei Yao
Maria J Ludwikow
Thu Phan
Ge Peng
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenoport Inc filed Critical Xenoport Inc
Publication of SG145759A1 publication Critical patent/SG145759A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
SG200806169-9A 2003-08-20 2004-08-20 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use SG145759A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49693803P 2003-08-20 2003-08-20
US60663704P 2004-08-13 2004-08-13

Publications (1)

Publication Number Publication Date
SG145759A1 true SG145759A1 (en) 2008-09-29

Family

ID=36762986

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200806169-9A SG145759A1 (en) 2003-08-20 2004-08-20 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Country Status (14)

Country Link
EP (1) EP1660440B1 (fr)
JP (3) JP5148874B2 (fr)
CN (2) CN101914040A (fr)
AT (1) ATE546427T1 (fr)
CA (1) CA2536257C (fr)
CY (1) CY1112827T1 (fr)
ES (1) ES2382000T3 (fr)
HK (1) HK1090912A1 (fr)
IL (1) IL173826A (fr)
NO (1) NO335606B1 (fr)
NZ (1) NZ545719A (fr)
PL (1) PL1660440T3 (fr)
RU (2) RU2423347C2 (fr)
SG (1) SG145759A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG145759A1 (en) * 2003-08-20 2008-09-29 Xenoport Inc Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
CA2706575C (fr) * 2008-01-25 2015-07-14 Xenoport, Inc. Resolution des enantiomeres de thiocarbonates d'acyloxyalkyle utilises dans la synthese de precurseurs de carbamates d'acyloxyalkyle
JP6925080B2 (ja) * 2017-08-25 2021-08-25 ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司Ｇｕａｎｇｚｈｏｕ Ｈｅｎｏｖｃｏｍ Ｂｉｏｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ 長時間作用型ラサギリンプロドラッグ、その製造方法および用途
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法
CN117623989A (zh) * 2022-08-29 2024-03-01 广州市恒诺康医药科技有限公司 一种mao-b抑制剂前药的多晶型及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3475065D1 (en) * 1983-06-23 1988-12-15 Merck & Co Inc (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
AU2002345664C1 (en) * 2001-06-11 2008-03-06 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
SG145759A1 (en) * 2003-08-20 2008-09-29 Xenoport Inc Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Also Published As

Publication number Publication date
EP1660440A2 (fr) 2006-05-31
CA2536257A1 (fr) 2005-03-03
CY1112827T1 (el) 2016-02-10
IL173826A (en) 2014-07-31
RU2423347C2 (ru) 2011-07-10
JP2011256182A (ja) 2011-12-22
CN1860101A (zh) 2006-11-08
ATE546427T1 (de) 2012-03-15
EP1660440B1 (fr) 2012-02-22
HK1090912A1 (en) 2007-01-05
NO20061268L (no) 2006-05-22
CA2536257C (fr) 2012-01-03
JP2013006842A (ja) 2013-01-10
CN1860101B (zh) 2010-10-27
JP2007521318A (ja) 2007-08-02
CN101914040A (zh) 2010-12-15
RU2010147826A (ru) 2012-05-27
RU2006108541A (ru) 2007-09-27
ES2382000T3 (es) 2012-06-04
NO335606B1 (no) 2015-01-12
PL1660440T3 (pl) 2012-07-31
NZ545719A (en) 2010-03-26
IL173826A0 (en) 2006-07-05
JP5148874B2 (ja) 2013-02-20

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