SG11202108840XA - Producing compositions comprising two or more antibodies. - Google Patents

Producing compositions comprising two or more antibodies.

Info

Publication number
SG11202108840XA
SG11202108840XA SG11202108840XA SG11202108840XA SG11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA
Authority
SG
Singapore
Prior art keywords
antibodies
producing compositions
compositions
producing
Prior art date
Application number
SG11202108840XA
Other languages
English (en)
Inventor
Robert Paul Doornbos
Alexander Berthold Hendrik Bakker
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv filed Critical Merus Nv
Publication of SG11202108840XA publication Critical patent/SG11202108840XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
SG11202108840XA 2019-02-14 2020-02-13 Producing compositions comprising two or more antibodies. SG11202108840XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19157286 2019-02-14
EP19178542 2019-06-05
PCT/NL2020/050080 WO2020167122A1 (fr) 2019-02-14 2020-02-13 Production de compositions comprenant deux anticorps ou plus

Publications (1)

Publication Number Publication Date
SG11202108840XA true SG11202108840XA (en) 2021-09-29

Family

ID=69771002

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108840XA SG11202108840XA (en) 2019-02-14 2020-02-13 Producing compositions comprising two or more antibodies.

Country Status (13)

Country Link
US (1) US20220127375A1 (fr)
EP (1) EP3924377A1 (fr)
JP (2) JP7375027B2 (fr)
KR (1) KR20210126699A (fr)
AU (1) AU2020221649A1 (fr)
BR (1) BR112021016092A2 (fr)
CA (1) CA3130246A1 (fr)
IL (1) IL285489A (fr)
MA (1) MA54943A (fr)
MX (1) MX2021009769A (fr)
SG (1) SG11202108840XA (fr)
TW (1) TW202045132A (fr)
WO (1) WO2020167122A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201920275A (zh) * 2017-07-06 2019-06-01 荷蘭商米樂斯股份有限公司 藉由細胞表現之調控生物活性的抗體
US20220281914A1 (en) * 2020-12-18 2022-09-08 Kiniksa Pharmaceuticals, Ltd. Protein compositions and methods for producing and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040092719A1 (en) * 2002-09-17 2004-05-13 Eszter Birck-Wilson Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
EP1639009B1 (fr) 2003-05-30 2013-02-27 Merus B.V. Bibliothèque de fragments fab pour préparer un mélange d'anticorps
US10118970B2 (en) 2006-08-30 2018-11-06 Genentech, Inc. Multispecific antibodies
EP2556747B1 (fr) 2008-06-27 2020-12-02 Merus N.V. Souris transgéniques produisant un anticorps
ES2572728T3 (es) 2009-03-20 2016-06-02 F. Hoffmann-La Roche Ag Anticuerpos anti-HER biespecíficos
RU2606264C2 (ru) * 2009-12-25 2017-01-10 Чугаи Сеияку Кабушики Каиша Способ полипептидной модификации для очистки полипептидных мультимеров
NZ630551A (en) 2012-04-20 2017-11-24 Merus Nv Methods and means for the production of ig-like molecules
CN105473612A (zh) * 2013-08-19 2016-04-06 豪夫迈·罗氏有限公司 用羟基磷灰石层析分离双特异性抗体和双特异性抗体生产副产物
CA3065447A1 (fr) * 2017-06-05 2018-12-13 Janssen Biotech, Inc. Procedes d'ingenierie de charge de surface pour la production d'un anticorps bispecifique

Also Published As

Publication number Publication date
US20220127375A1 (en) 2022-04-28
MA54943A (fr) 2021-12-22
EP3924377A1 (fr) 2021-12-22
KR20210126699A (ko) 2021-10-20
BR112021016092A2 (pt) 2021-10-26
IL285489A (en) 2021-09-30
AU2020221649A1 (en) 2021-09-02
WO2020167122A1 (fr) 2020-08-20
JP7375027B2 (ja) 2023-11-07
MX2021009769A (es) 2021-09-08
JP2022520972A (ja) 2022-04-04
TW202045132A (zh) 2020-12-16
CA3130246A1 (fr) 2020-08-20
JP2023171492A (ja) 2023-12-01

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