SG11202108840XA - Producing compositions comprising two or more antibodies. - Google Patents

Producing compositions comprising two or more antibodies.

Info

Publication number
SG11202108840XA
SG11202108840XA SG11202108840XA SG11202108840XA SG11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA SG 11202108840X A SG11202108840X A SG 11202108840XA
Authority
SG
Singapore
Prior art keywords
antibodies
producing compositions
compositions
producing
Prior art date
Application number
SG11202108840XA
Inventor
Robert Paul Doornbos
Alexander Berthold Hendrik Bakker
Original Assignee
Merus Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus Nv filed Critical Merus Nv
Publication of SG11202108840XA publication Critical patent/SG11202108840XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11202108840XA 2019-02-14 2020-02-13 Producing compositions comprising two or more antibodies. SG11202108840XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19157286 2019-02-14
EP19178542 2019-06-05
PCT/NL2020/050080 WO2020167122A1 (en) 2019-02-14 2020-02-13 Producing compositions comprising two or more antibodies.

Publications (1)

Publication Number Publication Date
SG11202108840XA true SG11202108840XA (en) 2021-09-29

Family

ID=69771002

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202108840XA SG11202108840XA (en) 2019-02-14 2020-02-13 Producing compositions comprising two or more antibodies.

Country Status (13)

Country Link
US (1) US20220127375A1 (en)
EP (1) EP3924377A1 (en)
JP (2) JP7375027B2 (en)
KR (1) KR20210126699A (en)
AU (1) AU2020221649A1 (en)
BR (1) BR112021016092A2 (en)
CA (1) CA3130246A1 (en)
IL (1) IL285489A (en)
MA (1) MA54943A (en)
MX (1) MX2021009769A (en)
SG (1) SG11202108840XA (en)
TW (1) TW202045132A (en)
WO (1) WO2020167122A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3649156A1 (en) * 2017-07-06 2020-05-13 Merus N.V. Antibodies that modulate a biological activity expressed by a cell
US20220281914A1 (en) * 2020-12-18 2022-09-08 Kiniksa Pharmaceuticals, Ltd. Protein compositions and methods for producing and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003267135A1 (en) * 2002-09-17 2004-04-08 Gtc Biotherapeutics, Inc. Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
WO2004106375A1 (en) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Fab library for the preparation of anti vegf and anti rabies virus fabs
EP2471816A1 (en) 2006-08-30 2012-07-04 Genentech, Inc. Multispecific antibodies
EP3456190B1 (en) 2008-06-27 2021-11-24 Merus N.V. Antibody producing transgenic murine animal
SG174378A1 (en) 2009-03-20 2011-10-28 Genentech Inc Bispecific anti-her antibodies
SI2522724T1 (en) * 2009-12-25 2020-07-31 Chuqai Seiyaku Kabushiki Kaisha Polypeptide modification method for purifying polypeptide multimers
PT2838917T (en) 2012-04-20 2019-09-12 Merus Nv Methods and means for the production of heterodimeric ig-like molecules
BR112016003196A8 (en) * 2013-08-19 2020-02-04 Hoffmann La Roche method for separating bispecific antibodies
KR102661320B1 (en) * 2017-06-05 2024-05-03 얀센 바이오테크 인코포레이티드 Surface charge manipulation method for generating bispecific antibodies

Also Published As

Publication number Publication date
EP3924377A1 (en) 2021-12-22
TW202045132A (en) 2020-12-16
US20220127375A1 (en) 2022-04-28
CA3130246A1 (en) 2020-08-20
JP2022520972A (en) 2022-04-04
JP7375027B2 (en) 2023-11-07
MA54943A (en) 2021-12-22
AU2020221649A1 (en) 2021-09-02
MX2021009769A (en) 2021-09-08
WO2020167122A1 (en) 2020-08-20
KR20210126699A (en) 2021-10-20
JP2023171492A (en) 2023-12-01
IL285489A (en) 2021-09-30
BR112021016092A2 (en) 2021-10-26

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