SG11202106232TA - Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors - Google Patents

Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors

Info

Publication number
SG11202106232TA
SG11202106232TA SG11202106232TA SG11202106232TA SG11202106232TA SG 11202106232T A SG11202106232T A SG 11202106232TA SG 11202106232T A SG11202106232T A SG 11202106232TA SG 11202106232T A SG11202106232T A SG 11202106232TA SG 11202106232T A SG11202106232T A SG 11202106232TA
Authority
SG
Singapore
Prior art keywords
substituted
usp1
ubiquitin
inhibitors
specific
Prior art date
Application number
SG11202106232TA
Other languages
English (en)
Inventor
Jehrod Burnett Brenneman
Elsa Beyer Krall
Michael Schlabach
Andrew Alistair Wylie
Original Assignee
Ksq Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ksq Therapeutics Inc filed Critical Ksq Therapeutics Inc
Publication of SG11202106232TA publication Critical patent/SG11202106232TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11202106232TA 2018-12-20 2019-12-19 Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors SG11202106232TA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862783014P 2018-12-20 2018-12-20
US201962799423P 2019-01-31 2019-01-31
US201962857986P 2019-06-06 2019-06-06
US201962868616P 2019-06-28 2019-06-28
US201962946263P 2019-12-10 2019-12-10
PCT/US2019/067521 WO2020132269A1 (en) 2018-12-20 2019-12-19 Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors

Publications (1)

Publication Number Publication Date
SG11202106232TA true SG11202106232TA (en) 2021-07-29

Family

ID=71100912

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106232TA SG11202106232TA (en) 2018-12-20 2019-12-19 Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (usp1) inhibitors

Country Status (15)

Country Link
US (2) US11485736B2 (pt)
EP (1) EP3897652A4 (pt)
JP (1) JP2022511515A (pt)
KR (1) KR20210105887A (pt)
CN (1) CN113164485A (pt)
AU (1) AU2019405925A1 (pt)
BR (1) BR112021010715A2 (pt)
CA (1) CA3122108A1 (pt)
CL (1) CL2021001575A1 (pt)
CO (1) CO2021009078A2 (pt)
IL (1) IL284050A (pt)
MX (1) MX2021007179A (pt)
SG (1) SG11202106232TA (pt)
TW (1) TWI834784B (pt)
WO (1) WO2020132269A1 (pt)

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WO2023083285A1 (en) * 2021-11-12 2023-05-19 Insilico Medicine Ip Limited Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
CA3235765A1 (en) * 2021-11-12 2023-05-19 Jianping Wu Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
CN114181237B (zh) * 2021-12-01 2024-02-23 上海凌凯医药科技有限公司 一种1-异丙基吡唑-5-硼酸频那醇酯的合成方法
WO2023108048A2 (en) * 2021-12-09 2023-06-15 KSQ Therapeutics, Inc. Methods of preparing substituted pyrazolopyrimidines
WO2023143424A1 (zh) * 2022-01-27 2023-08-03 四川海思科制药有限公司 一种氮杂并环衍生物及其在医药上的应用
WO2023148643A1 (en) * 2022-02-03 2023-08-10 Aurigene Oncology Limited Fused bicyclic heterocyclyl compounds as usp1 inhibitors
WO2023155866A1 (zh) * 2022-02-18 2023-08-24 四川海思科制药有限公司 一种吡唑并吡啶衍生物及其在医药上的应用
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WO2023208130A1 (zh) * 2022-04-29 2023-11-02 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途
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WO2024046471A1 (zh) * 2022-09-02 2024-03-07 上海齐鲁制药研究中心有限公司 Usp1抑制剂
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Also Published As

Publication number Publication date
WO2020132269A1 (en) 2020-06-25
EP3897652A1 (en) 2021-10-27
AU2019405925A1 (en) 2021-07-29
BR112021010715A2 (pt) 2021-11-16
JP2022511515A (ja) 2022-01-31
EP3897652A4 (en) 2022-09-14
TWI834784B (zh) 2024-03-11
CA3122108A1 (en) 2020-06-25
CO2021009078A2 (es) 2021-10-29
KR20210105887A (ko) 2021-08-27
US11787813B2 (en) 2023-10-17
US11485736B2 (en) 2022-11-01
IL284050A (en) 2021-08-31
MX2021007179A (es) 2021-09-28
TW202039501A (zh) 2020-11-01
US20210115049A1 (en) 2021-04-22
CN113164485A (zh) 2021-07-23
US20230203046A1 (en) 2023-06-29
CL2021001575A1 (es) 2022-06-03

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