SG11202105228SA - C11-cyclic substituted 13-membered macrolides and uses thereof - Google Patents

C11-cyclic substituted 13-membered macrolides and uses thereof

Info

Publication number
SG11202105228SA
SG11202105228SA SG11202105228SA SG11202105228SA SG11202105228SA SG 11202105228S A SG11202105228S A SG 11202105228SA SG 11202105228S A SG11202105228S A SG 11202105228SA SG 11202105228S A SG11202105228S A SG 11202105228SA SG 11202105228S A SG11202105228S A SG 11202105228SA
Authority
SG
Singapore
Prior art keywords
cyclic substituted
membered macrolides
macrolides
membered
cyclic
Prior art date
Application number
SG11202105228SA
Other languages
English (en)
Inventor
Roger B Clark
Richard Alm
Wesley Francis Austin
Vijaya Gondi
Philip Hogan
Ivan Jewett
Sushmita D Lahiri
Jonathan F Lawrence
Xiben Li
Shuhao Shi
Wenying Wang
Yoshitaka Ichikawa
Andrew G Myers
Ziyang Zhang
Peter Niels Carlsen
Md Ataur Rahman
Original Assignee
Zikani Therapeutics Inc
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zikani Therapeutics Inc, Harvard College filed Critical Zikani Therapeutics Inc
Publication of SG11202105228SA publication Critical patent/SG11202105228SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
SG11202105228SA 2018-11-19 2019-11-18 C11-cyclic substituted 13-membered macrolides and uses thereof SG11202105228SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862769413P 2018-11-19 2018-11-19
PCT/US2019/062045 WO2020106636A1 (en) 2018-11-19 2019-11-18 C11-cyclic substituted 13-membered macrolides and uses thereof

Publications (1)

Publication Number Publication Date
SG11202105228SA true SG11202105228SA (en) 2021-06-29

Family

ID=68965978

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105228SA SG11202105228SA (en) 2018-11-19 2019-11-18 C11-cyclic substituted 13-membered macrolides and uses thereof

Country Status (12)

Country Link
US (1) US20220177508A1 (https=)
EP (1) EP3883945A1 (https=)
JP (1) JP2022507795A (https=)
KR (1) KR20210123288A (https=)
CN (1) CN113646319A (https=)
AU (2) AU2019385383B2 (https=)
BR (1) BR112021009607A2 (https=)
CA (1) CA3120235A1 (https=)
IL (2) IL310280A (https=)
MX (1) MX2021005421A (https=)
SG (1) SG11202105228SA (https=)
WO (1) WO2020106636A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313065A (zh) * 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023235380A1 (en) * 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) * 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
KR20250048331A (ko) * 2022-08-11 2025-04-08 지카니 테라퓨틱스, 인크. 치료용 아자케톨라이드 제조용 합성 공정 및 중간체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
BRPI0017013B1 (pt) * 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
WO2003014136A1 (en) * 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
JP6437523B2 (ja) * 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN106998685A (zh) * 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
EP3273969A4 (en) * 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof

Also Published As

Publication number Publication date
BR112021009607A2 (pt) 2021-08-10
IL283185B2 (en) 2024-06-01
CN113646319A (zh) 2021-11-12
IL310280A (en) 2024-03-01
MX2021005421A (es) 2021-09-21
IL283185B1 (en) 2024-02-01
EP3883945A1 (en) 2021-09-29
US20220177508A1 (en) 2022-06-09
WO2020106636A1 (en) 2020-05-28
JP2022507795A (ja) 2022-01-18
AU2019385383A1 (en) 2021-07-01
AU2019385383B2 (en) 2023-06-15
KR20210123288A (ko) 2021-10-13
IL283185A (en) 2021-06-30
AU2023229518A1 (en) 2023-09-28
CA3120235A1 (en) 2020-05-28

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