JP2022507795A - Ｃ１０環状置換１３員マクロライド及びそれらの使用 - Google Patents
Ｃ１０環状置換１３員マクロライド及びそれらの使用 Download PDFInfo
- Publication number
- JP2022507795A JP2022507795A JP2021527866A JP2021527866A JP2022507795A JP 2022507795 A JP2022507795 A JP 2022507795A JP 2021527866 A JP2021527866 A JP 2021527866A JP 2021527866 A JP2021527866 A JP 2021527866A JP 2022507795 A JP2022507795 A JP 2022507795A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- optionally substituted
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
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| US201862769413P | 2018-11-19 | 2018-11-19 | |
| US62/769,413 | 2018-11-19 | ||
| PCT/US2019/062045 WO2020106636A1 (en) | 2018-11-19 | 2019-11-18 | C11-cyclic substituted 13-membered macrolides and uses thereof |
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| JP2022507795A true JP2022507795A (ja) | 2022-01-18 |
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| TW202313065A (zh) * | 2021-05-28 | 2023-04-01 | 美商季卡尼醫療公司 | 用於治療遺傳疾病之化合物 |
| WO2023235380A1 (en) * | 2022-06-01 | 2023-12-07 | Zikani Therapeutics, Inc. | Macrolides for treating genetic diseases |
| WO2023250513A1 (en) * | 2022-06-24 | 2023-12-28 | Zikani Therapeutics, Inc. | 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation |
| KR20250048331A (ko) * | 2022-08-11 | 2025-04-08 | 지카니 테라퓨틱스, 인크. | 치료용 아자케톨라이드 제조용 합성 공정 및 중간체 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000031097A1 (en) * | 1998-11-20 | 2000-06-02 | Pfizer Products Inc. | 13-membered azalides and their use as antibiotic agents |
| WO2003014136A1 (en) * | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
| WO2004108744A2 (en) * | 2003-05-19 | 2004-12-16 | Prasad K Deshpande | Azalides and azaketolides having antimicrobial activity |
| WO2007091393A1 (ja) * | 2006-02-07 | 2007-08-16 | Taisho Pharmaceutical Co., Ltd. | １０ａ－アザライド化合物 |
| WO2012001089A1 (en) * | 2010-07-01 | 2012-01-05 | Novartis Ag | Antibiotic compositions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0017013B1 (pt) * | 2000-01-27 | 2015-07-14 | Zoetis P Llc | Composição de antibiótico azalídeo e método para sua obtenção |
| JP6437523B2 (ja) * | 2013-04-04 | 2018-12-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | マクロライドならびにそれらの調製および使用の方法 |
| CN106998685A (zh) * | 2014-10-08 | 2017-08-01 | 哈佛大学的校长及成员们 | 14‑元酮内酯及其制备和使用方法 |
| EP3273969A4 (en) * | 2015-03-25 | 2018-11-21 | President and Fellows of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
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2023
- 2023-09-13 AU AU2023229518A patent/AU2023229518A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000031097A1 (en) * | 1998-11-20 | 2000-06-02 | Pfizer Products Inc. | 13-membered azalides and their use as antibiotic agents |
| WO2003014136A1 (en) * | 2001-08-08 | 2003-02-20 | Taisho Pharmaceutical Co., Ltd. | 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME |
| WO2004108744A2 (en) * | 2003-05-19 | 2004-12-16 | Prasad K Deshpande | Azalides and azaketolides having antimicrobial activity |
| WO2007091393A1 (ja) * | 2006-02-07 | 2007-08-16 | Taisho Pharmaceutical Co., Ltd. | １０ａ－アザライド化合物 |
| WO2012001089A1 (en) * | 2010-07-01 | 2012-01-05 | Novartis Ag | Antibiotic compositions |
Non-Patent Citations (1)
| Title |
|---|
| TETRAHEDRON, vol. 53, JPN6023050114, 1997, pages 16923 - 16944, ISSN: 0005213110 * |
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| BR112021009607A2 (pt) | 2021-08-10 |
| IL283185B2 (en) | 2024-06-01 |
| CN113646319A (zh) | 2021-11-12 |
| IL310280A (en) | 2024-03-01 |
| MX2021005421A (es) | 2021-09-21 |
| IL283185B1 (en) | 2024-02-01 |
| EP3883945A1 (en) | 2021-09-29 |
| SG11202105228SA (en) | 2021-06-29 |
| US20220177508A1 (en) | 2022-06-09 |
| WO2020106636A1 (en) | 2020-05-28 |
| AU2019385383A1 (en) | 2021-07-01 |
| AU2019385383B2 (en) | 2023-06-15 |
| KR20210123288A (ko) | 2021-10-13 |
| IL283185A (en) | 2021-06-30 |
| AU2023229518A1 (en) | 2023-09-28 |
| CA3120235A1 (en) | 2020-05-28 |
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