KR20210123288A - C11-환식 치환된 13-원 마크롤라이드 및 이의 용도 - Google Patents

C11-환식 치환된 13-원 마크롤라이드 및 이의 용도 Download PDF

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Publication number
KR20210123288A
KR20210123288A KR1020217018877A KR20217018877A KR20210123288A KR 20210123288 A KR20210123288 A KR 20210123288A KR 1020217018877 A KR1020217018877 A KR 1020217018877A KR 20217018877 A KR20217018877 A KR 20217018877A KR 20210123288 A KR20210123288 A KR 20210123288A
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KR
South Korea
Prior art keywords
optionally substituted
alkyl
group
compound
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020217018877A
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English (en)
Korean (ko)
Inventor
로저 비. 클락
리차드 알람
웨슬리 프란시스 오스틴
비자야 곤디
필립 호간
이반 주이트
수스미타 디. 라히리
조나단 에프. 로렌스
시벤 리
수하오 시
웬잉 왕
요시타카 이치카와
앤드류 지. 마이어스
지양 장
피터 니엘스 칼센
엠디. 아타우르 라만
Original Assignee
지카니 테라퓨틱스, 인크.
프레지던트 앤드 펠로우즈 오브 하바드 칼리지
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Application filed by 지카니 테라퓨틱스, 인크., 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 filed Critical 지카니 테라퓨틱스, 인크.
Publication of KR20210123288A publication Critical patent/KR20210123288A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
KR1020217018877A 2018-11-19 2019-11-18 C11-환식 치환된 13-원 마크롤라이드 및 이의 용도 Ceased KR20210123288A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769413P 2018-11-19 2018-11-19
US62/769,413 2018-11-19
PCT/US2019/062045 WO2020106636A1 (en) 2018-11-19 2019-11-18 C11-cyclic substituted 13-membered macrolides and uses thereof

Publications (1)

Publication Number Publication Date
KR20210123288A true KR20210123288A (ko) 2021-10-13

Family

ID=68965978

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217018877A Ceased KR20210123288A (ko) 2018-11-19 2019-11-18 C11-환식 치환된 13-원 마크롤라이드 및 이의 용도

Country Status (12)

Country Link
US (1) US20220177508A1 (https=)
EP (1) EP3883945A1 (https=)
JP (1) JP2022507795A (https=)
KR (1) KR20210123288A (https=)
CN (1) CN113646319A (https=)
AU (2) AU2019385383B2 (https=)
BR (1) BR112021009607A2 (https=)
CA (1) CA3120235A1 (https=)
IL (2) IL310280A (https=)
MX (1) MX2021005421A (https=)
SG (1) SG11202105228SA (https=)
WO (1) WO2020106636A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313065A (zh) * 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023235380A1 (en) * 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) * 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
KR20250048331A (ko) * 2022-08-11 2025-04-08 지카니 테라퓨틱스, 인크. 치료용 아자케톨라이드 제조용 합성 공정 및 중간체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
BRPI0017013B1 (pt) * 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
WO2003014136A1 (en) * 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
JP6437523B2 (ja) * 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN106998685A (zh) * 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
EP3273969A4 (en) * 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof

Also Published As

Publication number Publication date
BR112021009607A2 (pt) 2021-08-10
IL283185B2 (en) 2024-06-01
CN113646319A (zh) 2021-11-12
IL310280A (en) 2024-03-01
MX2021005421A (es) 2021-09-21
IL283185B1 (en) 2024-02-01
EP3883945A1 (en) 2021-09-29
SG11202105228SA (en) 2021-06-29
US20220177508A1 (en) 2022-06-09
WO2020106636A1 (en) 2020-05-28
JP2022507795A (ja) 2022-01-18
AU2019385383A1 (en) 2021-07-01
AU2019385383B2 (en) 2023-06-15
IL283185A (en) 2021-06-30
AU2023229518A1 (en) 2023-09-28
CA3120235A1 (en) 2020-05-28

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Patent event date: 20210618

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Patent event date: 20221118

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