AU2019385383B2 - C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof - Google Patents

C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof Download PDF

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Publication number
AU2019385383B2
AU2019385383B2 AU2019385383A AU2019385383A AU2019385383B2 AU 2019385383 B2 AU2019385383 B2 AU 2019385383B2 AU 2019385383 A AU2019385383 A AU 2019385383A AU 2019385383 A AU2019385383 A AU 2019385383A AU 2019385383 B2 AU2019385383 B2 AU 2019385383B2
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AU
Australia
Prior art keywords
alkyl
optionally substituted
group
compound
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019385383A
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English (en)
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AU2019385383A1 (en
Inventor
Richard Alm
Wesley Francis Austin
Peter Niels Carlsen
Roger B. Clark
Vijaya GONDI
Philip Hogan
Yoshitaka Ichikawa
Ivan JEWETT
Sushmita D. LAHIRI
Jonathan F. LAWRENCE
Xiben LI
Andrew G. Myers
Md. Ataur RAHMAN
Shuhao Shi
Wenying Wang
Ziyang Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Zikani Therapeutics Inc
Original Assignee
Harvard University
Zikani Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Harvard University, Zikani Therapeutics Inc filed Critical Harvard University
Publication of AU2019385383A1 publication Critical patent/AU2019385383A1/en
Application granted granted Critical
Publication of AU2019385383B2 publication Critical patent/AU2019385383B2/en
Priority to AU2023229518A priority Critical patent/AU2023229518A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
AU2019385383A 2018-11-19 2019-11-18 C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof Active AU2019385383B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023229518A AU2023229518A1 (en) 2018-11-19 2023-09-13 C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862769413P 2018-11-19 2018-11-19
US62/769,413 2018-11-19
PCT/US2019/062045 WO2020106636A1 (en) 2018-11-19 2019-11-18 C11-cyclic substituted 13-membered macrolides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023229518A Division AU2023229518A1 (en) 2018-11-19 2023-09-13 C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof

Publications (2)

Publication Number Publication Date
AU2019385383A1 AU2019385383A1 (en) 2021-07-01
AU2019385383B2 true AU2019385383B2 (en) 2023-06-15

Family

ID=68965978

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019385383A Active AU2019385383B2 (en) 2018-11-19 2019-11-18 C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof
AU2023229518A Abandoned AU2023229518A1 (en) 2018-11-19 2023-09-13 C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2023229518A Abandoned AU2023229518A1 (en) 2018-11-19 2023-09-13 C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof

Country Status (12)

Country Link
US (1) US20220177508A1 (https=)
EP (1) EP3883945A1 (https=)
JP (1) JP2022507795A (https=)
KR (1) KR20210123288A (https=)
CN (1) CN113646319A (https=)
AU (2) AU2019385383B2 (https=)
BR (1) BR112021009607A2 (https=)
CA (1) CA3120235A1 (https=)
IL (2) IL310280A (https=)
MX (1) MX2021005421A (https=)
SG (1) SG11202105228SA (https=)
WO (1) WO2020106636A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313065A (zh) * 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023235380A1 (en) * 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) * 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
KR20250048331A (ko) * 2022-08-11 2025-04-08 지카니 테라퓨틱스, 인크. 치료용 아자케톨라이드 제조용 합성 공정 및 중간체

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0017013B1 (pt) * 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
WO2003014136A1 (en) * 2001-08-08 2003-02-20 Taisho Pharmaceutical Co., Ltd. 11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
JP6437523B2 (ja) * 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN106998685A (zh) * 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
EP3273969A4 (en) * 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

Also Published As

Publication number Publication date
BR112021009607A2 (pt) 2021-08-10
IL283185B2 (en) 2024-06-01
CN113646319A (zh) 2021-11-12
IL310280A (en) 2024-03-01
MX2021005421A (es) 2021-09-21
IL283185B1 (en) 2024-02-01
EP3883945A1 (en) 2021-09-29
SG11202105228SA (en) 2021-06-29
US20220177508A1 (en) 2022-06-09
WO2020106636A1 (en) 2020-05-28
JP2022507795A (ja) 2022-01-18
AU2019385383A1 (en) 2021-07-01
KR20210123288A (ko) 2021-10-13
IL283185A (en) 2021-06-30
AU2023229518A1 (en) 2023-09-28
CA3120235A1 (en) 2020-05-28

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ C10-CYCLIC SUBSTITUTED 13-MEMBERED MACROLIDES AND USES THEREOF

FGA Letters patent sealed or granted (standard patent)