SG11202011638WA - Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof - Google Patents

Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof

Info

Publication number
SG11202011638WA
SG11202011638WA SG11202011638WA SG11202011638WA SG11202011638WA SG 11202011638W A SG11202011638W A SG 11202011638WA SG 11202011638W A SG11202011638W A SG 11202011638WA SG 11202011638W A SG11202011638W A SG 11202011638WA SG 11202011638W A SG11202011638W A SG 11202011638WA
Authority
SG
Singapore
Prior art keywords
fused
preparation
pharmaceutical composition
method therefor
formamide compound
Prior art date
Application number
SG11202011638WA
Other languages
English (en)
Inventor
Hong Liu
Meiyu Geng
Yu Zhou
Jian Ding
Feifei Fang
Jing Ai
Jian Li
Xia Peng
Hualiang Jiang
Yinchun Ji
Kaixian Chen
Original Assignee
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute Of Materia Medica Chinese Academy Of Sciences filed Critical Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Publication of SG11202011638WA publication Critical patent/SG11202011638WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11202011638WA 2018-05-21 2019-05-21 Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof SG11202011638WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810491115.3A CN110511218A (zh) 2018-05-21 2018-05-21 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途
PCT/CN2019/087867 WO2019223704A1 (zh) 2018-05-21 2019-05-21 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途

Publications (1)

Publication Number Publication Date
SG11202011638WA true SG11202011638WA (en) 2020-12-30

Family

ID=68615979

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011638WA SG11202011638WA (en) 2018-05-21 2019-05-21 Fused-cyclic pyrazolone formamide compound and preparation method therefor, pharmaceutical composition and use thereof

Country Status (11)

Country Link
US (1) US20210221807A1 (zh)
EP (1) EP3798218A4 (zh)
JP (1) JP7339282B2 (zh)
KR (1) KR102658011B1 (zh)
CN (2) CN110511218A (zh)
AU (1) AU2019273337B2 (zh)
BR (1) BR112020023870A2 (zh)
CA (1) CA3101223A1 (zh)
EA (1) EA202092766A1 (zh)
SG (1) SG11202011638WA (zh)
WO (1) WO2019223704A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
CN113683629B (zh) * 2020-05-18 2023-07-04 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
WO2024039842A2 (en) * 2022-08-19 2024-02-22 National Health Research Institutes Inhibitors of tam receptors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
EP2349328A1 (en) * 2008-10-01 2011-08-03 Ludwig Institute For Cancer Research Methods for the treatment of cancer
KR100961410B1 (ko) * 2008-10-14 2010-06-09 (주)네오팜 단백질 키나제 억제제로서 헤테로사이클릭 화합물
CN102086211B (zh) * 2009-12-08 2013-09-11 广东东阳光药业有限公司 作为蛋白激酶抑制剂的芳杂环化合物
EP3045453A1 (en) * 2011-11-14 2016-07-20 Cephalon, Inc. Uracil derivatives as axl and c-met kinase inhibitors
CN104974162B (zh) 2014-04-09 2018-09-14 广东东阳光药业有限公司 双环吡唑酮化合物及其使用方法和用途
EP3239147B9 (en) * 2014-12-25 2020-01-08 Ono Pharmaceutical Co., Ltd. Quinoline derivative

Also Published As

Publication number Publication date
BR112020023870A2 (pt) 2021-02-09
AU2019273337A1 (en) 2021-01-21
WO2019223704A1 (zh) 2019-11-28
JP2021524471A (ja) 2021-09-13
EP3798218A4 (en) 2022-03-02
JP7339282B2 (ja) 2023-09-05
US20210221807A1 (en) 2021-07-22
AU2019273337B2 (en) 2022-02-17
EA202092766A1 (ru) 2021-07-08
EP3798218A1 (en) 2021-03-31
CN112236430B (zh) 2023-02-17
CN112236430A (zh) 2021-01-15
KR20210011988A (ko) 2021-02-02
KR102658011B1 (ko) 2024-04-17
CA3101223A1 (en) 2019-11-28
CN110511218A (zh) 2019-11-29

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