PL3750893T3 - Związek dioksazoliny, sposób jego wytwarzania oraz jego zastosowania - Google Patents

Związek dioksazoliny, sposób jego wytwarzania oraz jego zastosowania

Info

Publication number
PL3750893T3
PL3750893T3 PL19751025.8T PL19751025T PL3750893T3 PL 3750893 T3 PL3750893 T3 PL 3750893T3 PL 19751025 T PL19751025 T PL 19751025T PL 3750893 T3 PL3750893 T3 PL 3750893T3
Authority
PL
Poland
Prior art keywords
preparation
method therefor
dioxazoline compound
dioxazoline
compound
Prior art date
Application number
PL19751025.8T
Other languages
English (en)
Inventor
Qiang Zhang
Shannan YU
Zhongxiang WANG
Shouye FENG
Yueming SUN
Yansheng Liu
Hongbo Zhang
Leifu YANG
Hailong Yang
Likai ZHOU
Nanqiao ZHENG
Chenming Hu
Zhanqiang XU
Original Assignee
Beijing Scitech-Mq Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2018/076233 external-priority patent/WO2018153293A1/zh
Priority claimed from CN201810983341.3A external-priority patent/CN110156803A/zh
Application filed by Beijing Scitech-Mq Pharmaceuticals Limited filed Critical Beijing Scitech-Mq Pharmaceuticals Limited
Publication of PL3750893T3 publication Critical patent/PL3750893T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL19751025.8T 2018-02-11 2019-01-25 Związek dioksazoliny, sposób jego wytwarzania oraz jego zastosowania PL3750893T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2018/076233 WO2018153293A1 (zh) 2017-02-27 2018-02-11 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用
CN201810983341.3A CN110156803A (zh) 2017-02-27 2018-08-27 二噁烷并喹啉类化合物及其制备方法与应用
PCT/CN2019/073260 WO2019154133A1 (zh) 2018-02-11 2019-01-25 二噁烷并喹啉类化合物及其制备方法与应用

Publications (1)

Publication Number Publication Date
PL3750893T3 true PL3750893T3 (pl) 2023-07-17

Family

ID=67548179

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19751025.8T PL3750893T3 (pl) 2018-02-11 2019-01-25 Związek dioksazoliny, sposób jego wytwarzania oraz jego zastosowania

Country Status (7)

Country Link
US (1) US11407760B2 (pl)
EP (1) EP3750893B1 (pl)
JP (1) JP7022454B2 (pl)
KR (1) KR102433023B1 (pl)
CA (1) CA3090876C (pl)
PL (1) PL3750893T3 (pl)
WO (1) WO2019154133A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019079759A1 (en) 2017-10-19 2019-04-25 Laurence Rahme ANTI-PERSISTENCE AND ANTI-VIRULENCE COMPOUNDS WITH BROAD SPECTRUM
CN117986267A (zh) * 2022-11-01 2024-05-07 北京赛特明强医药科技有限公司 一种二噁烷并喹啉类化合物的盐、其晶型以及它们的制备方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425564B2 (en) 2001-06-22 2008-09-16 Kirin Beer Kabushiki Kaisha Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same
SI2392564T1 (sl) 2003-09-26 2014-02-28 Exelixis, Inc. c-Met modulatorji in postopki uporabe
US8664244B2 (en) 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
PT2621481T (pt) 2010-09-27 2019-11-19 Exelixis Inc Inibidores duplos de met e vegf para o tratamento de cancro da próstata resistente à castração e metástases ósseas osteoblásticas
CN104530063B (zh) 2015-01-13 2017-01-18 北京赛特明强医药科技有限公司 喹唑啉并杂环类化合物及其制备方法和作为用于治疗癌症的表皮生长因子受体抑制剂的应用
CN105837586B (zh) 2015-12-14 2018-02-13 北京赛特明强医药科技有限公司 二噁烷并喹唑啉胺类化合物及其制备方法和作为表皮生长因子受体抑制剂的应用
CN105541798B (zh) 2016-02-03 2018-01-23 中国人民解放军第二军医大学 具有抗肿瘤活性的喹啉类多靶点激酶抑制剂及其制备方法
WO2018153293A1 (zh) * 2017-02-27 2018-08-30 北京赛特明强医药科技有限公司 二噁烷并喹唑啉与二噁烷并喹啉类化合物及其制备方法与应用
WO2018157730A1 (zh) * 2017-03-01 2018-09-07 北京赛特明强医药科技有限公司 脲取代的芳环连二噁烷并喹唑啉与连二噁烷并喹啉类化合物及其制备方法与应用

Also Published As

Publication number Publication date
JP2021512930A (ja) 2021-05-20
EP3750893A4 (en) 2020-12-16
CA3090876C (en) 2022-12-06
WO2019154133A1 (zh) 2019-08-15
US20200399285A1 (en) 2020-12-24
CA3090876A1 (en) 2019-08-15
EP3750893A1 (en) 2020-12-16
EP3750893B1 (en) 2023-04-19
KR102433023B1 (ko) 2022-08-16
KR20200118146A (ko) 2020-10-14
JP7022454B2 (ja) 2022-02-18
US11407760B2 (en) 2022-08-09

Similar Documents

Publication Publication Date Title
SG11202007740TA (en) Pyrimidine-fused cyclic compound, preparation method therefor and application thereof
IL288104A (en) Heterocyclic compounds, preparation methods and their use
SG11202106706TA (en) Heterocyclic compound intermediate, preparation method therefor and application thereof
ZA202001447B (en) M-diamide compound and preparation method therefor and use thereof
SG11202105850YA (en) Diphenyl-like compound, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and uses thereof
SG11202003782XA (en) Triple-chain antibody, method for preparation and use thereof
SG11202000532SA (en) Compounds, compositions and methods
PT3676297T (pt) Compostos, composições e métodos
ZA201906131B (en) Herbicidal mixture, composition and method
EP3299369A4 (en) Pyrido-azaheterecydic compound and preparation method and use thereof
SG11202008132UA (en) Composition, method and use
SG11202007554TA (en) Dioxazoline compound, preparation method therefor, and uses thereof
EP3246327A4 (en) 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof
EP3112351A4 (en) Naphthylamide compound, preparation method and use thereof
SG11202007521PA (en) Urea-substituted aromatic ring-linked dioxazoline compound, preparation method therefor, and uses thereof
GB201705124D0 (en) Composition, method and use
SG11202107530WA (en) Steroid compound, and use thereof and preparation method therefor
GB2564511B (en) Composition, method and use
GB2576614B (en) Compositions, uses and methods
IL289416A (en) Tricyclic compound, its preparation method and use
IL270505B1 (en) Compounds, preparations and methods
PL3760633T3 (pl) Oksazynochinazolina i związek typu oksazynochinazoliny, sposób ich wytwarzania i ich zastosowania
IL282817A (en) New material, production method, and its use
EP3395808A4 (en) Pseudo-ceramide compound and preparation method therefor
EP3225627A4 (en) Tripeptide compound, preparation method therefor, and application thereof