EA202092766A1 - Конденсированные циклические производные пиразолона формамида, способ их получения, фармацевтическая композиция и их применение - Google Patents

Конденсированные циклические производные пиразолона формамида, способ их получения, фармацевтическая композиция и их применение

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Publication number
EA202092766A1
EA202092766A1 EA202092766A EA202092766A EA202092766A1 EA 202092766 A1 EA202092766 A1 EA 202092766A1 EA 202092766 A EA202092766 A EA 202092766A EA 202092766 A EA202092766 A EA 202092766A EA 202092766 A1 EA202092766 A1 EA 202092766A1
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EA
Eurasian Patent Office
Prior art keywords
preparation
pharmaceutical composition
condensed cyclic
application
cyclic derivatives
Prior art date
Application number
EA202092766A
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English (en)
Inventor
Хун Лю
Мэйюй Гэн
Юй Чжоу
Цзянь Дин
Фэйфэй Фан
Цзин Ай
Цзянь Ли
Ся Пэн
Хуалян Цзян
Иньчунь Цзи
Кайсянь ЧЭНЬ
Original Assignee
Шанхай Инститьют Оф Материа Медика, Чайниз Акэдеми Оф Сайнсез
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Application filed by Шанхай Инститьют Оф Материа Медика, Чайниз Акэдеми Оф Сайнсез filed Critical Шанхай Инститьют Оф Материа Медика, Чайниз Акэдеми Оф Сайнсез
Publication of EA202092766A1 publication Critical patent/EA202092766A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Предложены класс соединений в форме конденсированных циклических производных пиразолона формамида и способ их получения, фармацевтическая композиция и ее применение. В частности, предлагается соединение, имеющее структуру, показанную на формуле (I) (с каждой группой, определенной в описании). Соединение можно использовать в качестве ингибитора AXL при приготовлении фармацевтической композиции для лечения опухолей.
EA202092766A 2018-05-21 2019-05-21 Конденсированные циклические производные пиразолона формамида, способ их получения, фармацевтическая композиция и их применение EA202092766A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810491115.3A CN110511218A (zh) 2018-05-21 2018-05-21 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途
PCT/CN2019/087867 WO2019223704A1 (zh) 2018-05-21 2019-05-21 一类并环吡唑啉酮甲酰胺类化合物及其制备方法、药物组合物和用途

Publications (1)

Publication Number Publication Date
EA202092766A1 true EA202092766A1 (ru) 2021-07-08

Family

ID=68615979

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092766A EA202092766A1 (ru) 2018-05-21 2019-05-21 Конденсированные циклические производные пиразолона формамида, способ их получения, фармацевтическая композиция и их применение

Country Status (11)

Country Link
US (1) US20210221807A1 (ru)
EP (1) EP3798218A4 (ru)
JP (1) JP7339282B2 (ru)
KR (1) KR102658011B1 (ru)
CN (2) CN110511218A (ru)
AU (1) AU2019273337B2 (ru)
BR (1) BR112020023870A2 (ru)
CA (1) CA3101223A1 (ru)
EA (1) EA202092766A1 (ru)
SG (1) SG11202011638WA (ru)
WO (1) WO2019223704A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
CN113683629B (zh) * 2020-05-18 2023-07-04 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
WO2024039842A2 (en) * 2022-08-19 2024-02-22 National Health Research Institutes Inhibitors of tam receptors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
CA2738583A1 (en) * 2008-10-01 2010-04-08 Ludwig Institute For Cancer Research Methods for the treatment of cancer
KR100961410B1 (ko) * 2008-10-14 2010-06-09 (주)네오팜 단백질 키나제 억제제로서 헤테로사이클릭 화합물
CN102086211B (zh) 2009-12-08 2013-09-11 广东东阳光药业有限公司 作为蛋白激酶抑制剂的芳杂环化合物
AU2012339640B2 (en) * 2011-11-14 2017-01-05 Ignyta, Inc. Uracil derivatives as AXL and c-MET kinase inhibitors
CN104974162B (zh) * 2014-04-09 2018-09-14 广东东阳光药业有限公司 双环吡唑酮化合物及其使用方法和用途
US10208034B2 (en) * 2014-12-25 2019-02-19 Ono Pharmaceutical Co., Ltd. Quinoline derivative

Also Published As

Publication number Publication date
EP3798218A4 (en) 2022-03-02
AU2019273337A1 (en) 2021-01-21
CN112236430B (zh) 2023-02-17
KR20210011988A (ko) 2021-02-02
JP2021524471A (ja) 2021-09-13
KR102658011B1 (ko) 2024-04-17
SG11202011638WA (en) 2020-12-30
BR112020023870A2 (pt) 2021-02-09
CN112236430A (zh) 2021-01-15
CN110511218A (zh) 2019-11-29
CA3101223A1 (en) 2019-11-28
US20210221807A1 (en) 2021-07-22
EP3798218A1 (en) 2021-03-31
JP7339282B2 (ja) 2023-09-05
WO2019223704A1 (zh) 2019-11-28
AU2019273337B2 (en) 2022-02-17

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