SG11202011386QA - Polycyclic pyridone derivative - Google Patents
Polycyclic pyridone derivativeInfo
- Publication number
- SG11202011386QA SG11202011386QA SG11202011386QA SG11202011386QA SG11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA SG 11202011386Q A SG11202011386Q A SG 11202011386QA
- Authority
- SG
- Singapore
- Prior art keywords
- pyridone derivative
- polycyclic pyridone
- polycyclic
- derivative
- pyridone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018104160 | 2018-05-31 | ||
| PCT/JP2019/021445 WO2019230857A1 (fr) | 2018-05-31 | 2019-05-30 | Dérivé de pyridone polycyclique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202011386QA true SG11202011386QA (en) | 2020-12-30 |
Family
ID=68698906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202011386QA SG11202011386QA (en) | 2018-05-31 | 2019-05-30 | Polycyclic pyridone derivative |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11453669B2 (fr) |
| EP (1) | EP3805221A4 (fr) |
| JP (1) | JP7353707B2 (fr) |
| KR (1) | KR20210018324A (fr) |
| CN (1) | CN112533922B (fr) |
| AU (1) | AU2019277547A1 (fr) |
| BR (1) | BR112020024098A2 (fr) |
| CA (1) | CA3101950A1 (fr) |
| CL (1) | CL2020002987A1 (fr) |
| CO (1) | CO2020014296A2 (fr) |
| CR (1) | CR20200645A (fr) |
| DO (1) | DOP2020000222A (fr) |
| EA (1) | EA202092923A1 (fr) |
| IL (1) | IL279050A (fr) |
| MA (1) | MA52802A (fr) |
| MX (1) | MX2020012185A (fr) |
| PE (1) | PE20201414A1 (fr) |
| PH (1) | PH12020551999A1 (fr) |
| SG (1) | SG11202011386QA (fr) |
| WO (1) | WO2019230857A1 (fr) |
| ZA (1) | ZA202007568B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019230858A1 (fr) | 2018-05-31 | 2019-12-05 | 塩野義製薬株式会社 | Dérivé de carbamoylpyridone polycyclique |
| PL3938047T3 (pl) | 2019-03-22 | 2022-11-07 | Gilead Sciences, Inc. | Zmostkowane tricykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne |
| US20230058677A1 (en) * | 2019-11-28 | 2023-02-23 | Shionogi & Co., Ltd. | Polycyclic pyridopyrazine derivative |
| WO2021107066A1 (fr) * | 2019-11-28 | 2021-06-03 | 塩野義製薬株式会社 | Agent pharmaceutique prophylactique et thérapeutique pour maladies infectieuses à vih, caractérisé en ce qu'il comprend une combinaison d'un inhibiteur d'intégrase et d'un agent anti-vih |
| AU2021225809B2 (en) | 2020-02-24 | 2023-08-24 | Gilead Sciences, Inc. | Tetracyclic compounds for treating HIV infection |
| CN115667270B (zh) * | 2020-05-21 | 2024-06-04 | 辰欣药业股份有限公司 | 稠环衍生物及其在药学上的应用 |
| FI4196479T3 (fi) | 2021-01-19 | 2024-01-17 | Gilead Sciences Inc | Substituoituja pyridotriatsiiniyhdisteitä ja niiden käyttöjä |
| EP4384178A1 (fr) * | 2021-08-11 | 2024-06-19 | Merck Sharp & Dohme LLC | Inhibiteurs polycycliques d'endonucléase cap-dépendante pour le traitement ou la prévention de la grippe |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1549315A4 (fr) | 2002-09-11 | 2007-05-23 | Merck & Co Inc | Composes de dihydroxypyridopyrazine-1,6-diones utiles en tant qu'inhibiteurs de l'integrase du vih |
| EP1578748B1 (fr) | 2002-12-27 | 2010-09-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Tetrahydro-4h-pyrido[1,2-a]pyrimidines et composes connexes convenant comme inhibiteurs de l'integrase du vih |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| WO2006088173A1 (fr) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Dérivé de carbamoylpyridone bicyclique ayant une activité d'inhibition de la vih intégrase |
| KR101504998B1 (ko) | 2005-04-28 | 2015-03-23 | 비이브 헬쓰케어 컴퍼니 | Ｈｉｖ 통합효소 억제 활성을 가지는 다환식 카르바모일피리돈 유도체 |
| KR20080064182A (ko) | 2005-10-27 | 2008-07-08 | 시오노기세야쿠 가부시키가이샤 | Ｈｉｖ 인테그라아제 억제활성을 가지는 다환성카르바모일피리돈 유도체 |
| SG183484A1 (en) | 2010-02-26 | 2012-09-27 | Japan Tobacco Inc | 1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor |
| US9216995B2 (en) | 2010-04-12 | 2015-12-22 | Shionogi & Co., Ltd. | Pyridone derivative having integrase inhibitory activity |
| BR112014008896A2 (pt) | 2011-10-12 | 2017-04-18 | Shionogi & Co | derivado de piridona policíclico tendo atividade inibidora de integrase |
| WO2014099586A1 (fr) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | Dérivés 4-pyridinonetriazines en tant qu'inhibiteurs de l'intégrase du vih |
| SG11201504857SA (en) | 2012-12-21 | 2015-07-30 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| US20140221380A1 (en) | 2012-12-27 | 2014-08-07 | Japan Tobacco Inc. | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR |
| RS56701B1 (sr) | 2013-05-17 | 2018-03-30 | Merck Sharp & Dohme | Fuzionisana triciklična heterociklična jedinjenja kao inhibitori hiv integraze |
| EP3008044B1 (fr) * | 2013-06-13 | 2018-11-21 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| WO2014200080A1 (fr) | 2013-06-14 | 2014-12-18 | ヤンマー株式会社 | Dispositif de prédiction, procédé de prédiction et programme informatique |
| NO2865735T3 (fr) | 2013-07-12 | 2018-07-21 | ||
| HUE037347T2 (hu) | 2013-07-12 | 2018-08-28 | Gilead Sciences Inc | Policiklusos karmaboilpiridon vegyületek és alkalmazásuk HIV fertõzések kezelésére |
| WO2015039348A1 (fr) | 2013-09-23 | 2015-03-26 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques utiles comme inhibiteurs de l'intégrase du vih |
| KR101809392B1 (ko) | 2013-09-27 | 2017-12-14 | 머크 샤프 앤드 돔 코포레이션 | Hiv 인테그라제 억제제로서 유용한 치환된 퀴놀리진 유도체 |
| WO2015089847A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Composés à hétérocycles spirocycliques utiles en tant qu'inhibiteurs d'intégrase du vih |
| WO2015199167A1 (fr) | 2014-06-25 | 2015-12-30 | 日本たばこ産業株式会社 | PROCÉDÉ POUR PRÉPARER UN DÉRIVÉ SUBSTITUÉ DE SPIROPYRIDO[1,2-a]PYRAZINE ET INTERMÉDIAIRE |
| JPWO2016027879A1 (ja) * | 2014-08-22 | 2017-06-01 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| WO2016094198A1 (fr) | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Composés hétérocycliques spirocycliques utiles comme inhibiteurs du vih |
| WO2016090545A1 (fr) * | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Composés hétérocycliques spirocycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| TWI695003B (zh) | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| EP3285582B1 (fr) | 2015-03-26 | 2020-11-11 | Merck Sharp & Dohme Corp. | Dérivés de quinolizine substitués par un phosphate utiles en tant qu'inhibiteurs de l'intégrase du vih |
| SI3466490T1 (sl) | 2015-04-02 | 2020-12-31 | Gilead Sciences, Inc. | Policiklične spojine karbamoilpiridona in njihova farmacevtska uporaba |
| WO2016187788A1 (fr) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles pour traiter l'infection au vih |
| EP3377065B1 (fr) | 2015-11-17 | 2022-05-18 | Merck Sharp & Dohme Corp. | Dérivés de pyridotriazine spirocyclique utiles en tant qu'inhibiteurs de l'intégrase du vih |
| US10548910B2 (en) | 2015-11-17 | 2020-02-04 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors |
| US10544155B2 (en) | 2015-12-15 | 2020-01-28 | Merck Sharp & Dohme Corp. | Spirocyclic quinolizine derivatives useful as HIV integrase inhibitors |
| WO2017113288A1 (fr) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| CN110062627A (zh) | 2016-12-02 | 2019-07-26 | 默沙东公司 | 可用作hiv整合酶抑制剂的三环杂环化合物 |
| EP3752144B1 (fr) | 2018-02-15 | 2022-12-28 | Merck Sharp & Dohme LLC | Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| CA3101180A1 (fr) | 2018-04-27 | 2019-10-31 | Merck Sharp & Dohme Corp. | Composes heterocycliques tricycliques utiles en tant qu'inhibiteurs de l'integrase du vih |
| CN110526930B (zh) | 2018-05-23 | 2022-06-03 | 莫云芬 | 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用 |
| EP3801543A4 (fr) | 2018-06-05 | 2022-03-02 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| PL3938047T3 (pl) | 2019-03-22 | 2022-11-07 | Gilead Sciences, Inc. | Zmostkowane tricykliczne związki karbamoilopirydonowe i ich zastosowanie farmaceutyczne |
-
2019
- 2019-05-30 MX MX2020012185A patent/MX2020012185A/es unknown
- 2019-05-30 MA MA052802A patent/MA52802A/fr unknown
- 2019-05-30 PE PE2020001864A patent/PE20201414A1/es unknown
- 2019-05-30 AU AU2019277547A patent/AU2019277547A1/en active Pending
- 2019-05-30 BR BR112020024098-2A patent/BR112020024098A2/pt unknown
- 2019-05-30 CR CR20200645A patent/CR20200645A/es unknown
- 2019-05-30 WO PCT/JP2019/021445 patent/WO2019230857A1/fr active Application Filing
- 2019-05-30 SG SG11202011386QA patent/SG11202011386QA/en unknown
- 2019-05-30 EP EP19812190.7A patent/EP3805221A4/fr active Pending
- 2019-05-30 KR KR1020207037581A patent/KR20210018324A/ko not_active Application Discontinuation
- 2019-05-30 US US17/058,260 patent/US11453669B2/en active Active
- 2019-05-30 CN CN201980050400.4A patent/CN112533922B/zh active Active
- 2019-05-30 JP JP2020522576A patent/JP7353707B2/ja active Active
- 2019-05-30 EA EA202092923A patent/EA202092923A1/ru unknown
- 2019-05-30 CA CA3101950A patent/CA3101950A1/fr active Pending
-
2020
- 2020-11-17 CL CL2020002987A patent/CL2020002987A1/es unknown
- 2020-11-18 CO CONC2020/0014296A patent/CO2020014296A2/es unknown
- 2020-11-20 PH PH12020551999A patent/PH12020551999A1/en unknown
- 2020-11-27 DO DO2020000222A patent/DOP2020000222A/es unknown
- 2020-11-29 IL IL279050A patent/IL279050A/en unknown
- 2020-12-04 ZA ZA2020/07568A patent/ZA202007568B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR20200645A (es) | 2021-02-05 |
| IL279050A (en) | 2021-01-31 |
| PH12020551999A1 (en) | 2021-09-27 |
| JP7353707B2 (ja) | 2023-10-02 |
| US20210155622A1 (en) | 2021-05-27 |
| JPWO2019230857A1 (ja) | 2021-06-24 |
| CL2020002987A1 (es) | 2021-04-16 |
| ZA202007568B (en) | 2022-04-28 |
| WO2019230857A1 (fr) | 2019-12-05 |
| DOP2020000222A (es) | 2021-03-15 |
| BR112020024098A2 (pt) | 2021-02-17 |
| CA3101950A1 (fr) | 2019-12-05 |
| KR20210018324A (ko) | 2021-02-17 |
| CO2020014296A2 (es) | 2020-12-21 |
| MX2020012185A (es) | 2021-01-29 |
| CN112533922A (zh) | 2021-03-19 |
| PE20201414A1 (es) | 2020-12-07 |
| EP3805221A1 (fr) | 2021-04-14 |
| EA202092923A1 (ru) | 2021-04-09 |
| CN112533922B (zh) | 2024-03-22 |
| US11453669B2 (en) | 2022-09-27 |
| MA52802A (fr) | 2021-04-14 |
| AU2019277547A1 (en) | 2021-01-14 |
| EP3805221A4 (fr) | 2022-01-05 |
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