SG11202007544RA - Water soluble salts of lipidated peptides and methods for preparing and using the same - Google Patents
Water soluble salts of lipidated peptides and methods for preparing and using the sameInfo
- Publication number
- SG11202007544RA SG11202007544RA SG11202007544RA SG11202007544RA SG11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA SG 11202007544R A SG11202007544R A SG 11202007544RA
- Authority
- SG
- Singapore
- Prior art keywords
- preparing
- methods
- same
- water soluble
- soluble salts
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Immunology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862636552P | 2018-02-28 | 2018-02-28 | |
| PCT/KR2019/002397 WO2019168357A1 (fr) | 2018-02-28 | 2019-02-27 | Sels hydrosolubles de peptides lipidés et leurs procédés de préparation et d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202007544RA true SG11202007544RA (en) | 2020-09-29 |
Family
ID=67684306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202007544RA SG11202007544RA (en) | 2018-02-28 | 2019-02-27 | Water soluble salts of lipidated peptides and methods for preparing and using the same |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11739120B2 (fr) |
| EP (1) | EP3759070A4 (fr) |
| JP (2) | JP7104141B2 (fr) |
| KR (1) | KR102058853B1 (fr) |
| CN (1) | CN110959002A (fr) |
| PH (1) | PH12020551233A1 (fr) |
| SG (1) | SG11202007544RA (fr) |
| TW (2) | TWI762770B (fr) |
| WO (1) | WO2019168357A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102104507B1 (ko) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
| CN111297905B (zh) * | 2020-03-18 | 2022-11-04 | 四川大学华西医院 | 一种基于皮肤前体细胞的提取物及其制备方法和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1195762B (it) * | 1980-10-13 | 1988-10-27 | Reiner Alberto Real Sas | Derivati idrosolubili della cefalexina e procedimento per la loro produzione |
| DE3839127A1 (de) | 1988-11-19 | 1990-05-23 | Hoechst Ag | Pyrrolidon-2-carbonsaeure-derivate mit psychotroper wirkung |
| AUPM906594A0 (en) | 1994-10-26 | 1994-11-17 | Peptide Technology Limited | Synthetic polyunsaturated fatty acid analogues |
| TR199802207T2 (xx) | 1996-05-01 | 2001-06-21 | Ortho-Mcneil Pharmacetical, Inc. | Tromboz'a kar�� kullan�lmaya mahsus pirrolidin, piperidin ve heksahidroazepin'in karboksamid t�revleri. |
| DE69915004T2 (de) | 1998-11-05 | 2004-09-09 | Pfizer Products Inc., Groton | 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate |
| US20030022938A1 (en) | 2001-06-25 | 2003-01-30 | Burstein Sumner H. | N-fatty acid-amino acid conjugates and therapeutic uses |
| US20060252698A1 (en) | 2005-04-20 | 2006-11-09 | Malcolm Bruce A | Compounds for inhibiting cathepsin activity |
| US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
| KR20100050559A (ko) * | 2007-08-29 | 2010-05-13 | 화이자 프로덕츠 인코포레이티드 | 3-(((4-ｔｅｒｔ-부틸-벤질)-(피리딘-3-설포닐)-아미노)-메틸)-페녹시)-아세트산 나트륨 염 또는 이의 수화물의 다형체 및 이를 제조하는 방법 |
| WO2010059922A1 (fr) * | 2008-11-21 | 2010-05-27 | Ligand Pharmaceuticals Incorporated | Composés de pyrrolidine carboxamide |
| KR101151878B1 (ko) | 2010-06-08 | 2012-05-31 | 미원상사주식회사 | 지방산 트리펩타이드염 및 이를 함유하는 항균 조성물 |
| KR101348284B1 (ko) | 2010-09-09 | 2014-01-03 | 주식회사 나이벡 | 인간 유래 세포 투과성 펩타이드와 생리활성 펩타이드 결합체 및 그 용도 |
| KR20120048864A (ko) | 2010-11-08 | 2012-05-16 | 주식회사 네오디엠 | 트리 펩타이드 유도체를 함유한 아토피 피부염 예방 및 치료용 조성물과 그 제조방법 |
| KR20130038426A (ko) | 2011-10-07 | 2013-04-18 | 성균관대학교산학협력단 | 지방산이 결합된 항당뇨 펩티드가 소수성 결합된 글리콜 키토산 히드로겔 및 이를 포함하는 당뇨병 예방 또는 치료용 약학적 조성물 |
| KR101359886B1 (ko) | 2011-12-28 | 2014-02-12 | 성균관대학교산학협력단 | 스매드 6번(Ｓｍａｄ６)으로부터 유래된 펩타이드를 유효성분으로 포함하는 패혈증 또는 패혈성 쇼크의 치료용 조성물 |
| US20150368197A1 (en) * | 2012-06-21 | 2015-12-24 | Radikal Therapeutics Ins. | Compositions and methods for treatment of inflammatory diseases of the lung |
| CN103724204B (zh) * | 2013-11-27 | 2016-05-11 | 北京化工大学 | 一种水溶性引发剂及制备 |
| CN115368438A (zh) * | 2015-07-08 | 2022-11-22 | 成均馆大学校产学协力团 | 吡咯烷酰胺衍生物及其制备和使用方法 |
-
2019
- 2019-02-27 CN CN201980003752.4A patent/CN110959002A/zh active Pending
- 2019-02-27 TW TW108106759A patent/TWI762770B/zh active
- 2019-02-27 WO PCT/KR2019/002397 patent/WO2019168357A1/fr unknown
- 2019-02-27 SG SG11202007544RA patent/SG11202007544RA/en unknown
- 2019-02-27 JP JP2020505847A patent/JP7104141B2/ja active Active
- 2019-02-27 EP EP19759922.8A patent/EP3759070A4/fr active Pending
- 2019-02-27 KR KR1020190023508A patent/KR102058853B1/ko active IP Right Grant
- 2019-02-27 TW TW110130498A patent/TWI811767B/zh active
- 2019-02-28 US US16/288,571 patent/US11739120B2/en active Active
-
2020
- 2020-08-10 PH PH12020551233A patent/PH12020551233A1/en unknown
-
2022
- 2022-04-15 JP JP2022067393A patent/JP2022106788A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3759070A4 (fr) | 2021-12-08 |
| PH12020551233A1 (en) | 2021-05-17 |
| TW201936577A (zh) | 2019-09-16 |
| JP7104141B2 (ja) | 2022-07-20 |
| WO2019168357A1 (fr) | 2019-09-06 |
| TWI762770B (zh) | 2022-05-01 |
| JP2022106788A (ja) | 2022-07-20 |
| TWI811767B (zh) | 2023-08-11 |
| CN110959002A (zh) | 2020-04-03 |
| KR102058853B1 (ko) | 2019-12-24 |
| US11739120B2 (en) | 2023-08-29 |
| EP3759070A1 (fr) | 2021-01-06 |
| KR20190103986A (ko) | 2019-09-05 |
| JP2020529435A (ja) | 2020-10-08 |
| TW202222818A (zh) | 2022-06-16 |
| US20190263859A1 (en) | 2019-08-29 |
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