SG11202006311SA - Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators - Google Patents
Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulatorsInfo
- Publication number
- SG11202006311SA SG11202006311SA SG11202006311SA SG11202006311SA SG11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA SG 11202006311S A SG11202006311S A SG 11202006311SA
- Authority
- SG
- Singapore
- Prior art keywords
- intermediates
- preparation
- guanylate cyclase
- soluble guanylate
- novel processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862615678P | 2018-01-10 | 2018-01-10 | |
| PCT/CN2018/076982 WO2019161534A1 (en) | 2018-02-22 | 2018-02-22 | Novel processes and intermediates for preparation of soluble guanylate cyclase stimulators |
| PCT/US2019/013060 WO2019140095A1 (en) | 2018-01-10 | 2019-01-10 | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202006311SA true SG11202006311SA (en) | 2020-07-29 |
Family
ID=65279655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202006311SA SG11202006311SA (en) | 2018-01-10 | 2019-01-10 | Novel processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US11274096B2 (enExample) |
| EP (3) | EP4570797A3 (enExample) |
| JP (2) | JP7357621B2 (enExample) |
| KR (3) | KR20250002720A (enExample) |
| CN (3) | CN118184645A (enExample) |
| AU (3) | AU2019206560B2 (enExample) |
| BR (1) | BR112020013985A2 (enExample) |
| CA (1) | CA3087943A1 (enExample) |
| CL (3) | CL2020001814A1 (enExample) |
| ES (1) | ES2963447T3 (enExample) |
| IL (3) | IL314714A (enExample) |
| JO (1) | JOP20200165A1 (enExample) |
| MA (2) | MA71753A (enExample) |
| MX (3) | MX2020007364A (enExample) |
| SG (1) | SG11202006311SA (enExample) |
| TW (2) | TWI888947B (enExample) |
| WO (1) | WO2019140095A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| US11274096B2 (en) | 2018-01-10 | 2022-03-15 | Cyclerion Therapeutics, Inc. | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
| CN118221651A (zh) * | 2022-12-21 | 2024-06-21 | 广东东阳光药业股份有限公司 | 氟取代的吲唑化合物的晶型及其用途 |
| AU2023412228A1 (en) * | 2022-12-21 | 2025-07-03 | Sunshine Lake Pharma Co., Ltd. | Crystal form of fluorine-substituted indazole compound and use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2588465B1 (en) * | 2010-06-30 | 2017-01-25 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EA033168B1 (ru) * | 2013-03-15 | 2019-09-30 | Сайклерион Терапьютикс, Инк. | СТИМУЛЯТОРЫ sGC |
| EP3094327A1 (en) * | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
| EP3194382B1 (en) | 2014-09-17 | 2021-09-08 | Cyclerion Therapeutics, Inc. | Pyrazole derivatives as sgc stimulators |
| EA201790627A1 (ru) * | 2014-09-17 | 2017-09-29 | Айронвуд Фармасьютикалз, Инк. | СТИМУЛЯТОРЫ рГЦ |
| CA3006746C (en) | 2015-11-30 | 2024-01-30 | Ironwood Pharmaceuticals, Inc. | Solid dispersions comprising a sgc stimulator |
| CN109563086B (zh) | 2016-07-07 | 2023-05-23 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的方法 |
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| US11274096B2 (en) | 2018-01-10 | 2022-03-15 | Cyclerion Therapeutics, Inc. | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators |
-
2019
- 2019-01-10 US US16/961,109 patent/US11274096B2/en active Active
- 2019-01-10 IL IL314714A patent/IL314714A/en unknown
- 2019-01-10 CN CN202410363182.2A patent/CN118184645A/zh active Pending
- 2019-01-10 KR KR1020247039985A patent/KR20250002720A/ko active Pending
- 2019-01-10 EP EP25174051.0A patent/EP4570797A3/en active Pending
- 2019-01-10 TW TW112138274A patent/TWI888947B/zh active
- 2019-01-10 CA CA3087943A patent/CA3087943A1/en active Pending
- 2019-01-10 SG SG11202006311SA patent/SG11202006311SA/en unknown
- 2019-01-10 WO PCT/US2019/013060 patent/WO2019140095A1/en not_active Ceased
- 2019-01-10 MA MA71753A patent/MA71753A/fr unknown
- 2019-01-10 AU AU2019206560A patent/AU2019206560B2/en active Active
- 2019-01-10 MA MA051565A patent/MA51565A/fr unknown
- 2019-01-10 TW TW108101044A patent/TWI821237B/zh active
- 2019-01-10 IL IL319883A patent/IL319883A/en unknown
- 2019-01-10 KR KR1020257010603A patent/KR20250048609A/ko active Pending
- 2019-01-10 CN CN202410363184.1A patent/CN118221665A/zh active Pending
- 2019-01-10 BR BR112020013985-8A patent/BR112020013985A2/pt active IP Right Grant
- 2019-01-10 ES ES19703440T patent/ES2963447T3/es active Active
- 2019-01-10 JO JOP/2020/0165A patent/JOP20200165A1/ar unknown
- 2019-01-10 EP EP19703440.8A patent/EP3737679B1/en active Active
- 2019-01-10 EP EP23187776.2A patent/EP4249469A3/en active Pending
- 2019-01-10 JP JP2020538535A patent/JP7357621B2/ja active Active
- 2019-01-10 KR KR1020207022640A patent/KR102739727B1/ko active Active
- 2019-01-10 MX MX2020007364A patent/MX2020007364A/es unknown
- 2019-01-10 IL IL275748A patent/IL275748B2/en unknown
- 2019-01-10 CN CN201980017700.2A patent/CN111902410B/zh active Active
-
2020
- 2020-07-07 CL CL2020001814A patent/CL2020001814A1/es unknown
- 2020-07-13 MX MX2023000045A patent/MX2023000045A/es unknown
- 2020-07-13 MX MX2023000044A patent/MX2023000044A/es unknown
-
2021
- 2021-10-08 US US17/497,352 patent/US11708361B2/en active Active
-
2022
- 2022-04-08 CL CL2022000907A patent/CL2022000907A1/es unknown
- 2022-04-08 CL CL2022000904A patent/CL2022000904A1/es unknown
-
2023
- 2023-04-28 US US18/140,966 patent/US12030874B2/en active Active
- 2023-09-26 JP JP2023162922A patent/JP7744955B2/ja active Active
- 2023-11-22 AU AU2023270260A patent/AU2023270260B2/en active Active
-
2024
- 2024-05-22 US US18/671,182 patent/US12275724B2/en active Active
-
2025
- 2025-03-31 AU AU2025202281A patent/AU2025202281A1/en active Pending
- 2025-04-11 US US19/176,742 patent/US20250361228A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL276917A (en) | A process for the preparation of alubixivet | |
| IL275748A (en) | PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF SOLUBLE GIONLIGHT CYCLAS FANS | |
| ZA202003590B (en) | Process for the preparation of opicapone and intermediates thereof | |
| GB202106894D0 (en) | Process for the preparation of 3alpha-hydroxy-5#LPHA-Pregnan-20-one (brexanolone) | |
| ZA202101214B (en) | Process and intermediates for the preparation of bilastine | |
| HUE062956T2 (hu) | Eljárások niraparib és köztitermékei elõállítására | |
| IL260665B (en) | Improved process for the preparation of osimertinib (azd9291) or its salt and "azd9291 aniline" or its salt | |
| IL289904B1 (en) | Process for preparing biphenylamines | |
| LT3765440T (lt) | N-alkil-nitratoetilnitraminų gamybos būdas | |
| IL263995B (en) | State-of-the-art processes for the preparation of soluble guanylate cyclase stimulators | |
| IL263994B (en) | Novel processes for preparation of soluble guanylate cyclase stimulators | |
| IL281254A (en) | A process for the preparation of lanbatinib | |
| IL272837A (en) | A process for preparing tubolysins and their intermediates | |
| PL3737685T3 (pl) | Sposób wytwarzania kryzaborolu i jego związków pośrednich | |
| ZA202107053B (en) | Novel process for the preparation of filgotinib and intermediates thereof | |
| IL281090A (en) | Alternative processes for the preparation of tubolysins and their intermediates | |
| HUE067201T2 (hu) | Eljárás és intermedier oxetan-2-il-metánamin elõállítására | |
| IL276852A (en) | A process for making soluble guinelate cyclase beads | |
| PL3599256T3 (pl) | Sposób wytwarzania poliorganosiloksanów | |
| IL278549B1 (en) | Intermediates and processes for the preparation of linagliptin and its salts | |
| HUE058725T2 (hu) | Eljárás aminok elõállítására | |
| HUP1800278A2 (en) | Process for the preparation of boc-linagliptin | |
| PT3969459T (pt) | Processo e intermediários para a preparação de eldecalcitol | |
| HK40034275A (en) | Process for preparing soluble guanylate cyclase stimulators | |
| HUP1800397A2 (en) | Process for the preparation of lumateperone and salts thereof |