SG11202004471RA - Immunostimulatory oligonucleotides - Google Patents
Immunostimulatory oligonucleotidesInfo
- Publication number
- SG11202004471RA SG11202004471RA SG11202004471RA SG11202004471RA SG11202004471RA SG 11202004471R A SG11202004471R A SG 11202004471RA SG 11202004471R A SG11202004471R A SG 11202004471RA SG 11202004471R A SG11202004471R A SG 11202004471RA SG 11202004471R A SG11202004471R A SG 11202004471RA
- Authority
- SG
- Singapore
- Prior art keywords
- immunostimulatory oligonucleotides
- immunostimulatory
- oligonucleotides
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17207750 | 2017-12-15 | ||
| EP17207746 | 2017-12-15 | ||
| EP17207740 | 2017-12-15 | ||
| PCT/EP2018/084019 WO2019115402A1 (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202004471RA true SG11202004471RA (en) | 2020-06-29 |
Family
ID=66818991
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202004471RA SG11202004471RA (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory oligonucleotides |
| SG11202004952UA SG11202004952UA (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory oligonucleotides |
| SG11202004773SA SG11202004773SA (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory compositions |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202004952UA SG11202004952UA (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory oligonucleotides |
| SG11202004773SA SG11202004773SA (en) | 2017-12-15 | 2018-12-07 | Immunostimulatory compositions |
Country Status (21)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020310853A1 (en) | 2019-07-05 | 2022-01-27 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| WO2021154745A1 (en) * | 2020-01-27 | 2021-08-05 | Oregon State University | Gonorrhea subunit vaccine |
| CN113493790A (zh) * | 2020-04-01 | 2021-10-12 | 南京华普生物技术股份有限公司 | 具有免疫调节功能的CpG ODN及其应用 |
| EP3892260A1 (en) * | 2020-04-10 | 2021-10-13 | Bayer Animal Health GmbH | Immunostimulatory compositions based on liposomes with zwiterionic and cationic lipids |
| EP4295917A3 (en) | 2020-08-07 | 2024-02-28 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| CN112159814B (zh) * | 2020-10-29 | 2023-05-16 | 中国农业科学院兰州兽医研究所 | 一种CpG寡聚脱氧核苷酸及制备与其用途 |
| CN113797329A (zh) * | 2021-10-19 | 2021-12-17 | 启锰生物科技(江苏)有限公司 | 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719028A (en) * | 1992-12-07 | 1998-02-17 | Third Wave Technologies Inc. | Cleavase fragment length polymorphism |
| DE69535036T3 (de) | 1994-07-15 | 2011-07-07 | The University of Iowa Research Foundation, IA | Immunomodulatorische oligonukleotide |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| RS50325B (sr) * | 1999-09-25 | 2009-09-08 | University Of Iowa Research Foundation, | Imunostimulatorne nukleinske kiseline |
| JP2003510290A (ja) * | 1999-09-27 | 2003-03-18 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫刺激核酸誘導インターフェロンに関する方法 |
| KR100359753B1 (ko) * | 1999-12-21 | 2002-11-09 | 주식회사 제넥신 | 면역조절능력 및 안전성이 증가되고 ｄＧ 연속서열이결합된 포스포다이에스터 ＣｐＧ올리고데옥시뉴클레오티드 변형체 |
| JP2004501666A (ja) | 2000-06-30 | 2004-01-22 | エピゲノミクス アーゲー | 薬理ゲノミクスのメチル化状態分析のための方法及び核酸 |
| AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| JP4874801B2 (ja) * | 2003-06-11 | 2012-02-15 | イデラ ファーマシューティカルズ インコーポレイテッド | 安定化免疫調節オリゴヌクレオチド |
| JP4989225B2 (ja) | 2003-09-25 | 2012-08-01 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 核酸親油性接合体 |
| KR101107818B1 (ko) * | 2003-10-30 | 2012-01-31 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 향상된 면역자극 효능을 가진 ｃ-부류 올리고뉴클레오티드유사체 |
| WO2005049647A2 (en) * | 2003-11-05 | 2005-06-02 | Pevion Biotech Ltd. | Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens |
| KR100558851B1 (ko) | 2004-01-08 | 2006-03-10 | 학교법인연세대학교 | 면역조절능력이 증가된 ＣｐＧ 올리고데옥시뉴클레오티드변형체 |
| CA2565714C (en) * | 2004-05-06 | 2014-12-23 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for the treatment of uveitis |
| AU2006216493A1 (en) * | 2005-02-24 | 2006-08-31 | Coley Pharmaceutical Gmbh | Immunostimulatory oligonucleotides |
| EP1764108A1 (en) * | 2005-09-14 | 2007-03-21 | Gunther Hartmann | Compositions comprising immunostimulatory RNA oligonucleotides and methods for producing said RNA oligonucleotides |
| US8114636B2 (en) * | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| PT2405002E (pt) | 2006-02-15 | 2015-01-05 | Adiutide Pharmaceuticals Gmbh | Composições e métodos para formulações de oligonucleotídeos |
| CN100418583C (zh) | 2006-02-21 | 2008-09-17 | 朱鸿飞 | 预防和治疗乳腺炎的药物组合物 |
| US20080124366A1 (en) * | 2006-08-06 | 2008-05-29 | Ohlfest John R | Methods and Compositions for Treating Tumors |
| CN102851295B (zh) * | 2006-08-28 | 2015-01-07 | 长春华普生物技术有限公司 | Toll 样受体调节性寡核苷酸及其用途 |
| MX2009003398A (es) | 2006-09-27 | 2009-08-12 | Coley Pharm Gmbh | Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada. |
| JP4847609B2 (ja) * | 2007-08-13 | 2011-12-28 | コーリー ファーマシューティカル ゲーエムベーハー | 特異的な免疫修飾プロフィールを誘発する規定されたヌクレオチド間結合との関連におけるｒｎａ配列モチーフ |
| US9012225B2 (en) | 2009-05-05 | 2015-04-21 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
| RU2570732C9 (ru) | 2009-05-14 | 2016-09-10 | Байер Интеллектуэль Проперти Гмбх | Усиленный иммунный ответ у видов птиц |
| NZ603527A (en) | 2010-05-28 | 2014-10-31 | Zoetis Belgium S A | Vaccines comprising cholesterol and cpg as sole adjuvant - carrier molecules |
| CN101979542B (zh) * | 2010-10-28 | 2011-12-28 | 国家兽用生物制品工程技术研究中心 | 含CpG基序的核酸序列的制备方法及应用 |
| LT2654785T (lt) | 2010-12-22 | 2019-07-10 | Bayer Intellectual Property Gmbh | Sustiprintas galvijų imuninis atsakas |
| EP2471926A3 (en) * | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| EP2714907B1 (en) * | 2011-05-26 | 2016-06-15 | Intervet International B.V. | Immunostimulatory oligodeoxynucleotides |
| PL2714908T3 (pl) * | 2011-05-26 | 2018-07-31 | Intervet International B.V. | Oligodeoksynukleotydy immunostymulacyjne |
| EP3563872A1 (en) | 2012-04-05 | 2019-11-06 | Massachusetts Institute Of Technology | Immunostimulatory compositions and methods of use thereof |
| AR091569A1 (es) | 2012-06-28 | 2015-02-11 | Intervet Int Bv | Receptores de tipo toll |
| AU2013347838A1 (en) | 2012-11-26 | 2015-06-11 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarker compositions and methods |
| TWI680767B (zh) | 2013-05-01 | 2020-01-01 | 美商雷格勒斯治療公司 | 用於增強的細胞攝取之化合物及方法 |
| TWI535451B (zh) * | 2013-07-19 | 2016-06-01 | 財團法人國家衛生研究院 | CpG寡去氧核苷酸、包含其之免疫組合物及組合物用於製備治療以刺激免疫反應的藥物之用途 |
| AR097029A1 (es) * | 2013-07-26 | 2016-02-17 | Intervet Int Bv | Aceleración de la respuesta inmune inducida por virus vectorial en aves, composición, uso, método para la vacunación y método para acelerar la respuesta inmune |
| GB2517700A (en) * | 2013-08-27 | 2015-03-04 | Lgc Ltd | Oligonucleotides comprising a secondary structure and uses thereof |
| UA118374C2 (uk) | 2014-02-28 | 2019-01-10 | Байєр Енімал Хелс Гмбх | Імуномодуляторна композиція та спосіб стимуляції імунної відповіді у суб'єкта |
| WO2017139570A1 (en) * | 2016-02-12 | 2017-08-17 | Massachusetts Intitute Of Technology | Synergistic tumor treatment with il-2, an integrin-binding-fc fusion protein, and a cancer vaccinne |
-
2018
- 2018-12-07 CN CN201880089469.3A patent/CN111801419A/zh active Pending
- 2018-12-07 SG SG11202004471RA patent/SG11202004471RA/en unknown
- 2018-12-07 KR KR1020207020349A patent/KR102787688B1/ko active Active
- 2018-12-07 CA CA3085575A patent/CA3085575A1/en active Pending
- 2018-12-07 AU AU2018385256A patent/AU2018385256A1/en active Pending
- 2018-12-07 CA CA3085661A patent/CA3085661A1/en active Pending
- 2018-12-07 EP EP18811581.0A patent/EP3701032A1/en active Pending
- 2018-12-07 CN CN201880080814.7A patent/CN111447949B/zh active Active
- 2018-12-07 US US16/772,541 patent/US11932857B2/en active Active
- 2018-12-07 BR BR112020011845-1A patent/BR112020011845A2/pt active Search and Examination
- 2018-12-07 JP JP2020531982A patent/JP2021506246A/ja active Pending
- 2018-12-07 SG SG11202004952UA patent/SG11202004952UA/en unknown
- 2018-12-07 US US16/772,046 patent/US11542507B2/en active Active
- 2018-12-07 KR KR1020207020351A patent/KR20200098638A/ko not_active Ceased
- 2018-12-07 JP JP2020531988A patent/JP7458977B2/ja active Active
- 2018-12-07 US US16/771,789 patent/US20210062192A1/en not_active Abandoned
- 2018-12-07 CN CN201880089491.8A patent/CN111801116B/zh active Active
- 2018-12-07 CN CN202411608245.2A patent/CN119656298A/zh active Pending
- 2018-12-07 SG SG11202004773SA patent/SG11202004773SA/en unknown
- 2018-12-07 CN CN202510619819.4A patent/CN120519464A/zh active Pending
- 2018-12-07 MX MX2020006244A patent/MX2020006244A/es unknown
- 2018-12-07 WO PCT/EP2018/083956 patent/WO2019115385A1/en not_active Application Discontinuation
- 2018-12-07 WO PCT/EP2018/083958 patent/WO2019115386A1/en active IP Right Grant
- 2018-12-07 KR KR1020257009617A patent/KR20250048594A/ko active Pending
- 2018-12-07 PE PE2020000765A patent/PE20210635A1/es unknown
- 2018-12-07 PE PE2020000767A patent/PE20200933A1/es unknown
- 2018-12-07 CR CR20200260A patent/CR20200260A/es unknown
- 2018-12-07 JP JP2020531972A patent/JP7273040B2/ja active Active
- 2018-12-07 AU AU2018382419A patent/AU2018382419B2/en active Active
- 2018-12-07 EP EP18829225.4A patent/EP3700564A1/en active Pending
- 2018-12-07 PE PE2020000766A patent/PE20210636A1/es unknown
- 2018-12-07 EP EP18829227.0A patent/EP3694549A1/en active Pending
- 2018-12-07 WO PCT/EP2018/084019 patent/WO2019115402A1/en active IP Right Grant
- 2018-12-07 BR BR112020011838-9A patent/BR112020011838A2/pt unknown
- 2018-12-07 BR BR112020011815-0A patent/BR112020011815A2/pt unknown
- 2018-12-07 MX MX2020006243A patent/MX2020006243A/es unknown
- 2018-12-07 MX MX2020006246A patent/MX2020006246A/es unknown
- 2018-12-07 CA CA3085657A patent/CA3085657A1/en active Pending
- 2018-12-07 AU AU2018385257A patent/AU2018385257B2/en active Active
- 2018-12-07 KR KR1020207020350A patent/KR20200099556A/ko not_active Ceased
- 2018-12-13 TW TW107144946A patent/TW201940192A/zh unknown
- 2018-12-13 TW TW107144947A patent/TWI821224B/zh active
- 2018-12-13 TW TW107144948A patent/TW201936924A/zh unknown
- 2018-12-14 UY UY0001038014A patent/UY38014A/es not_active Application Discontinuation
- 2018-12-14 UY UY0001038016A patent/UY38016A/es not_active Application Discontinuation
- 2018-12-14 UY UY0001038015A patent/UY38015A/es not_active Application Discontinuation
-
2020
- 2020-05-27 IL IL274975A patent/IL274975A/en unknown
- 2020-06-03 IL IL275086A patent/IL275086A/en unknown
- 2020-06-08 IL IL275217A patent/IL275217A/en unknown
- 2020-06-10 DO DO2020000106A patent/DOP2020000106A/es unknown
- 2020-06-10 DO DO2020000113A patent/DOP2020000113A/es unknown
- 2020-06-10 DO DO2020000107A patent/DOP2020000107A/es unknown
- 2020-06-11 CO CONC2020/0007102A patent/CO2020007102A2/es unknown
- 2020-06-11 CO CONC2020/0007100A patent/CO2020007100A2/es unknown
- 2020-06-11 CL CL2020001560A patent/CL2020001560A1/es unknown
- 2020-06-11 CO CONC2020/0007120A patent/CO2020007120A2/es unknown
- 2020-06-11 CL CL2020001561A patent/CL2020001561A1/es unknown
- 2020-06-11 CL CL2020001562A patent/CL2020001562A1/es unknown
- 2020-06-15 PH PH12020550904A patent/PH12020550904A1/en unknown
- 2020-06-15 PH PH12020550906A patent/PH12020550906A1/en unknown
- 2020-06-15 PH PH12020550903A patent/PH12020550903A1/en unknown
- 2020-07-13 MX MX2025007909A patent/MX2025007909A/es unknown
- 2020-07-14 ZA ZA2020/04317A patent/ZA202004317B/en unknown
-
2022
- 2022-08-08 US US17/883,031 patent/US12305173B2/en active Active
- 2022-11-18 US US18/057,053 patent/US20230332162A1/en active Pending
-
2023
- 2023-08-07 JP JP2023128316A patent/JP2023153970A/ja active Pending
- 2023-08-07 US US18/366,306 patent/US20240076681A1/en active Pending
- 2023-08-21 JP JP2023134080A patent/JP2023156485A/ja active Pending
-
2025
- 2025-01-31 US US19/043,004 patent/US20250215439A1/en active Pending
- 2025-06-20 AU AU2025204678A patent/AU2025204678A1/en active Pending
- 2025-07-03 AU AU2025205082A patent/AU2025205082A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL268422A (en) | Targeted oligonucleotides | |
| IL257921A (en) | Combination of immunostimulatory oligonucleotides | |
| GB201806688D0 (en) | No details | |
| GB201803663D0 (en) | No details | |
| GB201801258D0 (en) | No details | |
| GB201721011D0 (en) | No details | |
| GB201503408D0 (en) | Oligonucleotides | |
| IL275217A (en) | Oligonucleotides that stimulate the immune system | |
| EP3684343C0 (en) | IMPROVED SUPERPARTICLES | |
| GB201801628D0 (en) | No details | |
| GB201504124D0 (en) | Oligonucleotides | |
| GB201807647D0 (en) | No details | |
| SG10201913477UA (en) | G-quadruplex-containing antisense oligonucleotides | |
| IL272526A (en) | Enhanced endoinulinase proteins | |
| SG10201609048RA (en) | Antisense oligonucleotides | |
| GB201717719D0 (en) | No details | |
| GB201802344D0 (en) | No details | |
| GB201720890D0 (en) | No details | |
| GB201801239D0 (en) | No details | |
| EP3238727A4 (en) | Non-aggregating immunostimulatory oligonucleotides | |
| GB201811353D0 (en) | No details | |
| GB201709043D0 (en) | No details | |
| GB201714330D0 (en) | Oligonucleotides | |
| GB202000332D0 (en) | No details | |
| GB201811817D0 (en) | No details |