SG11202001642WA - Cycloolefin substituted heteroaromatic compounds and their use - Google Patents
Cycloolefin substituted heteroaromatic compounds and their useInfo
- Publication number
- SG11202001642WA SG11202001642WA SG11202001642WA SG11202001642WA SG11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA SG 11202001642W A SG11202001642W A SG 11202001642WA
- Authority
- SG
- Singapore
- Prior art keywords
- substituted heteroaromatic
- heteroaromatic compounds
- cycloolefin
- cycloolefin substituted
- compounds
- Prior art date
Links
- 125000000392 cycloalkenyl group Chemical group 0.000 title 1
- 150000002390 heteroarenes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710801364.3A CN109467538A (zh) | 2017-09-07 | 2017-09-07 | 环烯烃取代的杂芳环类化合物及其用途 |
PCT/CN2018/104531 WO2019047909A1 (en) | 2017-09-07 | 2018-09-07 | HETEROAROMATIC COMPOUNDS SUBSTITUTED WITH CYCLOOLEFINS AND THEIR USE |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202001642WA true SG11202001642WA (en) | 2020-03-30 |
Family
ID=65634832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202001642WA SG11202001642WA (en) | 2017-09-07 | 2018-09-07 | Cycloolefin substituted heteroaromatic compounds and their use |
Country Status (18)
Country | Link |
---|---|
US (2) | US11414390B2 (de) |
EP (1) | EP3679020A4 (de) |
JP (2) | JP7273030B6 (de) |
KR (1) | KR102566237B1 (de) |
CN (6) | CN109467538A (de) |
AR (1) | AR112794A1 (de) |
AU (1) | AU2018329047B2 (de) |
BR (1) | BR112020004563A2 (de) |
CA (1) | CA3073782A1 (de) |
CL (1) | CL2020000553A1 (de) |
EA (1) | EA202090653A1 (de) |
IL (1) | IL272923B2 (de) |
MX (1) | MX2020002505A (de) |
PE (1) | PE20200727A1 (de) |
PH (1) | PH12020500408A1 (de) |
SG (1) | SG11202001642WA (de) |
TW (1) | TWI816693B (de) |
WO (1) | WO2019047909A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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IL305085A (en) | 2017-09-07 | 2023-10-01 | Univ Res Inst Inc Augusta | A specific AKT3 activator and its uses |
CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药(上海)有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
CN116209655A (zh) * | 2020-11-09 | 2023-06-02 | 贝达药业股份有限公司 | 突变型idh1和idh2抑制剂及其应用 |
WO2023134686A1 (zh) * | 2022-01-11 | 2023-07-20 | 正大天晴药业集团股份有限公司 | 一种1,3,5-三嗪衍生物的制备方法 |
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EP0361489A3 (de) | 1988-09-30 | 1991-06-12 | Chugai Seiyaku Kabushiki Kaisha | 3,4-Diaminochinolin- und Pyridinverbindungen |
ES2306671T3 (es) | 1999-10-07 | 2008-11-16 | Amgen Inc. | Inhibidores de triazina quinasa. |
NZ551559A (en) | 2004-05-24 | 2008-10-31 | Equusys Inc | Animal instrumentation |
GB0512324D0 (en) * | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
AU2007234843B2 (en) | 2006-04-07 | 2013-07-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
EP2066645A2 (de) | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2-aminopyrimidinderivate als h4-rezeptorantagonisten, verfahren zu ihrer herstellung und ihre verwendung in pharmazeutischen zusammensetzungen |
US20100168077A1 (en) * | 2007-04-04 | 2010-07-01 | Ucb Pharma, S.A. | Novel Pyridine Derivatives, Processes for Preparing Them, Pharmaceutical Compositions Thereof |
JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
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WO2011078143A1 (ja) | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | ピリミジン誘導体およびそれらを含有する医薬組成物 |
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EP2755965B1 (de) | 2011-09-12 | 2017-07-26 | Merck Patent GmbH | Neue imidazolamine als kinaseaktivitätsmodulatoren |
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CN115536635A (zh) | 2012-01-06 | 2022-12-30 | 法国施维雅药厂 | 治疗活性化合物及其使用方法 |
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CN103044469A (zh) * | 2012-11-30 | 2013-04-17 | 大连联化化学有限公司 | 一种制备环戊烯/环己烯-1-硼酸频哪醇酯的方法 |
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JP6471155B2 (ja) * | 2013-07-11 | 2019-02-13 | アギオス ファーマシューティカルス,インコーポレーテッド | 癌の治療のためのidh2変異体阻害剤としてのn,6−ビス(アリール又はヘテロアリール)−1,3,5−トリアジン−2,4−ジアミン化合物 |
CN105517996B (zh) * | 2013-07-11 | 2019-03-26 | 安吉奥斯医药品有限公司 | 治疗活性化合物及其使用方法 |
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KR102303011B1 (ko) | 2015-07-30 | 2021-09-16 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 1,3,5-트라이아진 유도체 및 이의 사용 방법 |
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CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药(上海)有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
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2017
- 2017-09-07 CN CN201710801364.3A patent/CN109467538A/zh active Pending
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2018
- 2018-09-07 AU AU2018329047A patent/AU2018329047B2/en active Active
- 2018-09-07 JP JP2020513872A patent/JP7273030B6/ja active Active
- 2018-09-07 CN CN202311036829.2A patent/CN117797156A/zh active Pending
- 2018-09-07 KR KR1020207009621A patent/KR102566237B1/ko active IP Right Grant
- 2018-09-07 CN CN202311036787.2A patent/CN116999441A/zh active Pending
- 2018-09-07 SG SG11202001642WA patent/SG11202001642WA/en unknown
- 2018-09-07 US US16/645,329 patent/US11414390B2/en active Active
- 2018-09-07 CN CN202311040510.7A patent/CN117024363A/zh active Pending
- 2018-09-07 EP EP18853366.5A patent/EP3679020A4/de active Pending
- 2018-09-07 WO PCT/CN2018/104531 patent/WO2019047909A1/en unknown
- 2018-09-07 PE PE2020000280A patent/PE20200727A1/es unknown
- 2018-09-07 CA CA3073782A patent/CA3073782A1/en active Pending
- 2018-09-07 CN CN202311036845.1A patent/CN117257809A/zh active Pending
- 2018-09-07 BR BR112020004563-2A patent/BR112020004563A2/pt unknown
- 2018-09-07 CN CN201880057118.4A patent/CN111132967B/zh active Active
- 2018-09-07 MX MX2020002505A patent/MX2020002505A/es unknown
- 2018-09-07 EA EA202090653A patent/EA202090653A1/ru unknown
- 2018-09-07 TW TW107131525A patent/TWI816693B/zh active
- 2018-09-07 AR ARP180102548A patent/AR112794A1/es unknown
-
2020
- 2020-02-26 IL IL272923A patent/IL272923B2/en unknown
- 2020-02-28 PH PH12020500408A patent/PH12020500408A1/en unknown
- 2020-03-05 CL CL2020000553A patent/CL2020000553A1/es unknown
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2022
- 2022-05-18 US US17/747,925 patent/US20220372005A1/en active Pending
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2023
- 2023-04-26 JP JP2023072737A patent/JP2023103290A/ja active Pending
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