SG11202001127TA - In situ raman spectroscopy systems and methods for controlling process variables in cell cultures - Google Patents

In situ raman spectroscopy systems and methods for controlling process variables in cell cultures

Info

Publication number
SG11202001127TA
SG11202001127TA SG11202001127TA SG11202001127TA SG11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA
Authority
SG
Singapore
Prior art keywords
methods
cell cultures
raman spectroscopy
process variables
controlling process
Prior art date
Application number
SG11202001127TA
Other languages
English (en)
Inventor
Mark Czeterko
Anthony Debiase
William Pierce
Matthew Conway
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202001127TA publication Critical patent/SG11202001127TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Hardware Design (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202001127TA 2017-10-16 2018-10-15 In situ raman spectroscopy systems and methods for controlling process variables in cell cultures SG11202001127TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572828P 2017-10-16 2017-10-16
US201862662322P 2018-04-25 2018-04-25
PCT/US2018/055837 WO2019079165A1 (en) 2017-10-16 2018-10-15 RAMAN IN SITU SPECTROSCOPY SYSTEMS AND METHODS FOR CONTROLLING PROCESSING VARIABLES IN CELL CULTURES

Publications (1)

Publication Number Publication Date
SG11202001127TA true SG11202001127TA (en) 2020-03-30

Family

ID=64316979

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202001127TA SG11202001127TA (en) 2017-10-16 2018-10-15 In situ raman spectroscopy systems and methods for controlling process variables in cell cultures

Country Status (12)

Country Link
US (1) US20190112569A1 (zh)
EP (1) EP3698125A1 (zh)
JP (4) JP2020536497A (zh)
KR (1) KR20200070218A (zh)
CN (1) CN111201434A (zh)
BR (2) BR112020003122A2 (zh)
CA (1) CA3078956A1 (zh)
IL (1) IL272472A (zh)
MX (1) MX2020003555A (zh)
SG (1) SG11202001127TA (zh)
TW (1) TW201928042A (zh)
WO (1) WO2019079165A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11358984B2 (en) 2018-08-27 2022-06-14 Regeneran Pharmaceuticals, Inc. Use of Raman spectroscopy in downstream purification

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* Cited by examiner, † Cited by third party
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KR20200068697A (ko) 2017-10-06 2020-06-15 론자 리미티드 라만 분광법을 사용하는 세포 배양의 자동 제어
US11774287B2 (en) 2019-05-28 2023-10-03 WuXi Biologics Ireland Limited Raman spectroscopy integrated perfusion cell culture system for monitoring and auto-controlling perfusion cell culture
CN114867835A (zh) * 2019-10-18 2022-08-05 詹森生物科技公司 动态单糖控制方法
MX2022004941A (es) * 2019-10-25 2022-08-04 Regeneron Pharma Sistemas y metodos para la autoinoculacion en los procesos de expansion en serie y de produccion.
EP3822717B1 (en) 2019-11-15 2022-09-07 Sartorius Stedim Data Analytics AB Method and device assembly for predicting a parameter in a bioprocess based on raman spectroscopy and method and device assembly for controlling a bioprocess
CN114651218B (zh) * 2019-11-15 2023-09-15 赛多利斯司特蒂姆数据分析公司 基于拉曼光谱学预测生物过程中的参数的方法和装置组件以及控制生物过程的方法和装置组件
KR20230060189A (ko) * 2021-10-27 2023-05-04 프레스티지바이오로직스 주식회사 인공지능을 이용하여 세포 배양조건을 결정하기 위한 장치 및 장치의 동작 방법
JP7168118B1 (ja) 2022-06-23 2022-11-09 横河電機株式会社 検量装置、検量方法および検量プログラム
CN116855370A (zh) * 2023-07-19 2023-10-10 安及义实业（上海）有限公司 生物反应器或发酵罐的自动补料装置及方法

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JP2932791B2 (ja) * 1990-11-30 1999-08-09 味の素株式会社 微生物好気培養における炭素源濃度の制御方法及び装置
AR058140A1 (es) * 2005-10-24 2008-01-23 Wyeth Corp Metodo de produccion proteica utilizando compuestos anti-senescencia
WO2008036600A2 (en) * 2006-09-18 2008-03-27 Genentech, Inc. Methods of protein production
KR101523782B1 (ko) * 2006-11-08 2015-05-28 와이어쓰 엘엘씨 세포 배양을 위한 합리적으로 설계된 배지
TWI419902B (zh) * 2007-03-02 2013-12-21 百靈佳殷格翰製藥公司 蛋白質產製之改良
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
US9512214B2 (en) * 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
JP6616311B2 (ja) * 2014-10-15 2019-12-04 Ｊｘｔｇエネルギー株式会社 キシロースからエタノールを生産する酵母
JP6805166B2 (ja) * 2015-04-22 2020-12-23 バークレー ライツ，インコーポレイテッド マイクロ流体デバイス用の培養ステーション
WO2016196315A2 (en) * 2015-05-29 2016-12-08 Biogen Ma Inc. Cell culture methods and systems
KR20200068697A (ko) * 2017-10-06 2020-06-15 론자 리미티드 라만 분광법을 사용하는 세포 배양의 자동 제어

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11358984B2 (en) 2018-08-27 2022-06-14 Regeneran Pharmaceuticals, Inc. Use of Raman spectroscopy in downstream purification

Also Published As

Publication number Publication date
JP2024015034A (ja) 2024-02-01
JP2020536497A (ja) 2020-12-17
TW201928042A (zh) 2019-07-16
US20190112569A1 (en) 2019-04-18
CA3078956A1 (en) 2019-04-25
AU2018350890A1 (en) 2020-03-19
MX2020003555A (es) 2020-08-03
BR122023022045A2 (pt) 2024-01-16
JP2022153617A (ja) 2022-10-12
CN111201434A (zh) 2020-05-26
IL272472A (en) 2020-03-31
JP2020195370A (ja) 2020-12-10
BR112020003122A2 (pt) 2020-08-04
KR20200070218A (ko) 2020-06-17
EP3698125A1 (en) 2020-08-26
WO2019079165A1 (en) 2019-04-25

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