SG11202001127TA - In situ raman spectroscopy systems and methods for controlling process variables in cell cultures - Google Patents
In situ raman spectroscopy systems and methods for controlling process variables in cell culturesInfo
- Publication number
- SG11202001127TA SG11202001127TA SG11202001127TA SG11202001127TA SG11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA SG 11202001127T A SG11202001127T A SG 11202001127TA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- cell cultures
- raman spectroscopy
- process variables
- controlling process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Computer Hardware Design (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762572828P | 2017-10-16 | 2017-10-16 | |
| US201862662322P | 2018-04-25 | 2018-04-25 | |
| PCT/US2018/055837 WO2019079165A1 (en) | 2017-10-16 | 2018-10-15 | In situ raman spectroscopy systems and methods for controlling process variables in cell cultures |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202001127TA true SG11202001127TA (en) | 2020-03-30 |
Family
ID=64316979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001127TA SG11202001127TA (en) | 2017-10-16 | 2018-10-15 | In situ raman spectroscopy systems and methods for controlling process variables in cell cultures |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190112569A1 (en) |
| EP (1) | EP3698125A1 (en) |
| JP (4) | JP2020536497A (en) |
| KR (1) | KR20200070218A (en) |
| CN (1) | CN111201434A (en) |
| AU (1) | AU2018350890A1 (en) |
| BR (2) | BR122023022045A2 (en) |
| CA (1) | CA3078956A1 (en) |
| IL (1) | IL272472A (en) |
| MX (1) | MX2020003555A (en) |
| SG (1) | SG11202001127TA (en) |
| TW (1) | TW201928042A (en) |
| WO (1) | WO2019079165A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11358984B2 (en) | 2018-08-27 | 2022-06-14 | Regeneran Pharmaceuticals, Inc. | Use of Raman spectroscopy in downstream purification |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11609120B2 (en) | 2017-10-06 | 2023-03-21 | Lonza Ltd | Automated control of cell culture using Raman spectroscopy |
| US11774287B2 (en) | 2019-05-28 | 2023-10-03 | WuXi Biologics Ireland Limited | Raman spectroscopy integrated perfusion cell culture system for monitoring and auto-controlling perfusion cell culture |
| JP2022551999A (en) * | 2019-10-18 | 2022-12-14 | ヤンセン バイオテツク，インコーポレーテツド | dynamic monosaccharide control process |
| MX2022004941A (en) * | 2019-10-25 | 2022-08-04 | Regeneron Pharma | Systems and methods for auto-inoculation in seed train and production processes. |
| EP3822717B1 (en) * | 2019-11-15 | 2022-09-07 | Sartorius Stedim Data Analytics AB | Method and device assembly for predicting a parameter in a bioprocess based on raman spectroscopy and method and device assembly for controlling a bioprocess |
| CN114651218B (en) * | 2019-11-15 | 2023-09-15 | 赛多利斯司特蒂姆数据分析公司 | Method and device assembly for predicting parameters in a biological process based on raman spectroscopy, and method and device assembly for controlling a biological process |
| KR20230060189A (en) * | 2021-10-27 | 2023-05-04 | 프레스티지바이오로직스 주식회사 | Apparatus for determining cell culturing condition using artificial intelligence and operation method thereof |
| JP7168118B1 (en) | 2022-06-23 | 2022-11-09 | 横河電機株式会社 | Calibration device, calibration method and calibration program |
| CN116855370A (en) * | 2023-07-19 | 2023-10-10 | 安及义实业（上海）有限公司 | Automatic feeding device and method for bioreactor or fermentation tank |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2932791B2 (en) * | 1990-11-30 | 1999-08-09 | 味の素株式会社 | Method and apparatus for controlling carbon source concentration in microbial aerobic culture |
| PE20070796A1 (en) * | 2005-10-24 | 2007-08-15 | Wyeth Corp | PROTEIN PRODUCTION METHOD USING ANTI-SENESCENCE COMPOUNDS |
| US10982250B2 (en) * | 2006-09-18 | 2021-04-20 | Genentech, Inc. | Methods of protein production |
| JP5564259B2 (en) * | 2006-11-08 | 2014-07-30 | ワイス・エルエルシー | Reasonably designed medium for cell culture |
| DK2126093T3 (en) * | 2007-03-02 | 2013-01-07 | Boehringer Ingelheim Pharma | Improving protein production |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| US9512214B2 (en) * | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| JP6616311B2 (en) * | 2014-10-15 | 2019-12-04 | Ｊｘｔｇエネルギー株式会社 | Yeast producing ethanol from xylose |
| IL290119B2 (en) * | 2015-04-22 | 2024-03-01 | Berkeley Lights Inc | Culturing station for microfluidic device |
| WO2016196315A2 (en) * | 2015-05-29 | 2016-12-08 | Biogen Ma Inc. | Cell culture methods and systems |
| US11609120B2 (en) * | 2017-10-06 | 2023-03-21 | Lonza Ltd | Automated control of cell culture using Raman spectroscopy |
-
2018
- 2018-10-15 CN CN201880058522.3A patent/CN111201434A/en active Pending
- 2018-10-15 AU AU2018350890A patent/AU2018350890A1/en active Pending
- 2018-10-15 JP JP2020512702A patent/JP2020536497A/en not_active Withdrawn
- 2018-10-15 KR KR1020207004943A patent/KR20200070218A/en not_active Application Discontinuation
- 2018-10-15 MX MX2020003555A patent/MX2020003555A/en unknown
- 2018-10-15 US US16/160,194 patent/US20190112569A1/en active Pending
- 2018-10-15 BR BR122023022045-5A patent/BR122023022045A2/en unknown
- 2018-10-15 BR BR112020003122-4A patent/BR112020003122A2/en unknown
- 2018-10-15 SG SG11202001127TA patent/SG11202001127TA/en unknown
- 2018-10-15 CA CA3078956A patent/CA3078956A1/en active Pending
- 2018-10-15 WO PCT/US2018/055837 patent/WO2019079165A1/en unknown
- 2018-10-15 EP EP18803811.1A patent/EP3698125A1/en active Pending
- 2018-10-16 TW TW107136637A patent/TW201928042A/en unknown
-
2020
- 2020-02-05 IL IL272472A patent/IL272472A/en unknown
- 2020-05-12 JP JP2020083562A patent/JP2020195370A/en active Pending
-
2022
- 2022-08-03 JP JP2022123806A patent/JP2022153617A/en active Pending
-
2023
- 2023-11-24 JP JP2023198810A patent/JP2024015034A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11358984B2 (en) | 2018-08-27 | 2022-06-14 | Regeneran Pharmaceuticals, Inc. | Use of Raman spectroscopy in downstream purification |
Also Published As
| Publication number | Publication date |
|---|---|
| BR122023022045A2 (en) | 2024-01-16 |
| EP3698125A1 (en) | 2020-08-26 |
| BR112020003122A2 (en) | 2020-08-04 |
| IL272472A (en) | 2020-03-31 |
| CA3078956A1 (en) | 2019-04-25 |
| WO2019079165A1 (en) | 2019-04-25 |
| JP2022153617A (en) | 2022-10-12 |
| JP2020536497A (en) | 2020-12-17 |
| JP2020195370A (en) | 2020-12-10 |
| KR20200070218A (en) | 2020-06-17 |
| AU2018350890A1 (en) | 2020-03-19 |
| MX2020003555A (en) | 2020-08-03 |
| JP2024015034A (en) | 2024-02-01 |
| CN111201434A (en) | 2020-05-26 |
| TW201928042A (en) | 2019-07-16 |
| US20190112569A1 (en) | 2019-04-18 |
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