SG11201912385VA - Improved process for preparing imetelstat - Google Patents

Improved process for preparing imetelstat

Info

Publication number
SG11201912385VA
SG11201912385VA SG11201912385VA SG11201912385VA SG11201912385VA SG 11201912385V A SG11201912385V A SG 11201912385VA SG 11201912385V A SG11201912385V A SG 11201912385VA SG 11201912385V A SG11201912385V A SG 11201912385VA SG 11201912385V A SG11201912385V A SG 11201912385VA
Authority
SG
Singapore
Prior art keywords
imetelstat
preparing
improved process
improved
preparing imetelstat
Prior art date
Application number
SG11201912385VA
Other languages
English (en)
Inventor
Jale Muslehiddinoglu
Dinesh Gala
Jennifer Albaneze-Walker
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of SG11201912385VA publication Critical patent/SG11201912385VA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Specially Adapted For Manufacturing Cables (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201912385VA 2017-07-10 2018-07-09 Improved process for preparing imetelstat SG11201912385VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17180426 2017-07-10
PCT/EP2018/068485 WO2019011829A1 (en) 2017-07-10 2018-07-09 IMPROVED METHOD FOR PREPARING IMETELSTAT

Publications (1)

Publication Number Publication Date
SG11201912385VA true SG11201912385VA (en) 2020-01-30

Family

ID=59313083

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912385VA SG11201912385VA (en) 2017-07-10 2018-07-09 Improved process for preparing imetelstat

Country Status (30)

Country Link
US (4) US11332489B2 (uk)
EP (1) EP3652187B1 (uk)
JP (2) JP7199410B2 (uk)
KR (2) KR20240144459A (uk)
CN (1) CN110891961B (uk)
AU (2) AU2018298658B2 (uk)
BR (1) BR112020000410A2 (uk)
CA (2) CA3195922A1 (uk)
CL (1) CL2020000054A1 (uk)
CO (1) CO2020000096A2 (uk)
CY (1) CY1125351T1 (uk)
DK (1) DK3652187T3 (uk)
EA (1) EA038579B1 (uk)
ES (1) ES2901099T3 (uk)
HR (1) HRP20211940T1 (uk)
HU (1) HUE056722T2 (uk)
IL (1) IL271388B (uk)
LT (1) LT3652187T (uk)
MA (1) MA49555A (uk)
NZ (1) NZ760372A (uk)
PL (1) PL3652187T3 (uk)
PT (1) PT3652187T (uk)
RS (1) RS62705B1 (uk)
SA (1) SA520410996B1 (uk)
SG (1) SG11201912385VA (uk)
SI (1) SI3652187T1 (uk)
TW (1) TWI775895B (uk)
UA (1) UA125185C2 (uk)
WO (1) WO2019011829A1 (uk)
ZA (1) ZA201908452B (uk)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022005007A (es) 2019-10-28 2022-08-08 Geron Corp Sólidos cristalinos de 3-palmitoil-amido-1, 2-propanodiol y 3-palmitoil-amido-2-hidroxi-1-dimetoxitrifenilmetileter-propano y métodos para elaborarlos y usarlos.
US11530179B2 (en) 2019-10-28 2022-12-20 Geron Corporation Amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1 -(protected hydroxy)-propane salts and methods of making the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1210357E (pt) 1999-09-10 2008-06-11 Geron Corp Oligonucleótido-tiofosforamidatos n3'→p5': sua síntese e utilização
KR101319388B1 (ko) * 2003-09-09 2013-10-22 제론 코포레이션 텔로머라제 억제를 위한 변형 올리고뉴클레오티드
US7485717B2 (en) 2004-07-02 2009-02-03 Geron Corporation Synthesis of protected 3′-amino nucleoside monomers
AU2010262862C1 (en) 2009-06-17 2020-04-30 Biogen Ma Inc. Compositions and methods for modulation of SMN2 splicing in a subject
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
WO2017223258A1 (en) 2016-06-24 2017-12-28 Biogen Ma Inc. Synthesis of thiolated oligonucleotides without a capping step

Also Published As

Publication number Publication date
CL2020000054A1 (es) 2020-10-02
HRP20211940T1 (hr) 2022-03-18
MA49555A (fr) 2021-04-28
US20240262854A1 (en) 2024-08-08
CY1125351T1 (el) 2023-03-24
SA520410996B1 (ar) 2023-12-05
EA038579B1 (ru) 2021-09-17
EP3652187B1 (en) 2021-09-15
AU2018298658A1 (en) 2020-01-23
CA3066968A1 (en) 2019-01-17
HUE056722T2 (hu) 2022-03-28
US20200369702A1 (en) 2020-11-26
AU2022291626A1 (en) 2023-02-02
AU2018298658B2 (en) 2022-09-29
CA3195922A1 (en) 2019-01-17
LT3652187T (lt) 2022-01-25
CA3066968C (en) 2023-06-13
UA125185C2 (uk) 2022-01-26
PT3652187T (pt) 2021-12-16
ZA201908452B (en) 2022-03-30
US20240199672A1 (en) 2024-06-20
IL271388A (en) 2020-01-30
WO2019011829A1 (en) 2019-01-17
KR102709587B1 (ko) 2024-09-27
CN110891961B (zh) 2023-06-30
US20230070069A1 (en) 2023-03-09
JP2022183382A (ja) 2022-12-08
RS62705B1 (sr) 2022-01-31
EA202090006A1 (ru) 2020-05-18
TWI775895B (zh) 2022-09-01
EP3652187A1 (en) 2020-05-20
SI3652187T1 (sl) 2022-01-31
TW201920228A (zh) 2019-06-01
KR20200035267A (ko) 2020-04-02
JP2020526524A (ja) 2020-08-31
DK3652187T3 (da) 2021-12-13
JP7199410B2 (ja) 2023-01-05
NZ760372A (en) 2024-08-30
PL3652187T3 (pl) 2022-01-31
CO2020000096A2 (es) 2020-01-17
BR112020000410A2 (pt) 2020-07-14
ES2901099T3 (es) 2022-03-21
KR20240144459A (ko) 2024-10-02
CN110891961A (zh) 2020-03-17
IL271388B (en) 2022-03-01
US11332489B2 (en) 2022-05-17

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