SG11201912224PA - Novel method for synthesizing amanitins - Google Patents

Novel method for synthesizing amanitins

Info

Publication number
SG11201912224PA
SG11201912224PA SG11201912224PA SG11201912224PA SG11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA
Authority
SG
Singapore
Prior art keywords
amanitins
synthesizing
novel method
novel
synthesizing amanitins
Prior art date
Application number
SG11201912224PA
Other languages
English (en)
Inventor
Christian Lutz
Werner Simon
Susanne Werner-Simon
CHRISTOPH MüLLER
Thorsten Hechler
Michael Kulke
Original Assignee
Heidelberg Pharma Res Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Res Gmbh filed Critical Heidelberg Pharma Res Gmbh
Publication of SG11201912224PA publication Critical patent/SG11201912224PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817Toxins
    • A61K47/6831Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
SG11201912224PA 2017-08-07 2018-08-06 Novel method for synthesizing amanitins SG11201912224PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17185182 2017-08-07
PCT/EP2018/071268 WO2019030173A1 (en) 2017-08-07 2018-08-06 NOVEL METHOD FOR SYNTHESIZING AMANITINES

Publications (1)

Publication Number Publication Date
SG11201912224PA true SG11201912224PA (en) 2020-01-30

Family

ID=59579417

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912224PA SG11201912224PA (en) 2017-08-07 2018-08-06 Novel method for synthesizing amanitins

Country Status (14)

Country Link
US (2) US10961277B2 (ko)
EP (1) EP3665173A1 (ko)
JP (1) JP7165720B2 (ko)
KR (1) KR20200037207A (ko)
CN (1) CN111051310B (ko)
AU (1) AU2018314668B2 (ko)
BR (1) BR112020001345A2 (ko)
CA (1) CA3066867A1 (ko)
CL (1) CL2020000304A1 (ko)
CO (1) CO2020001259A2 (ko)
MX (1) MX2020001472A (ko)
SG (1) SG11201912224PA (ko)
WO (1) WO2019030173A1 (ko)
ZA (1) ZA201908158B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11420971B2 (en) 2017-08-07 2022-08-23 Heidelberg Pharma Research Gmbh Method for synthesizing amanitins
CA3095071A1 (en) * 2017-08-18 2019-02-21 Sichuan Baili Pharm Co. Ltd Non-natural amatoxin-type antibody conjugate
JP2021521202A (ja) * 2018-04-13 2021-08-26 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング 固形腫瘍の治療のための標的化されたアマトキシン複合体
SG11202104455XA (en) * 2018-12-11 2021-05-28 Heidelberg Pharma Res Gmbh Synthesis of (s)-6-hydroxytryptophan and derivatives thereof
SG11202110287QA (en) 2019-04-24 2021-10-28 Heidelberg Pharma Res Gmbh Amatoxin antibody-drug conjugates and uses thereof
CN115103854A (zh) * 2019-12-16 2022-09-23 海德堡医药研究有限责任公司 鹅膏素及其衍生物的合成
CN115715294A (zh) * 2020-06-09 2023-02-24 海德堡医药研究有限责任公司 用于合成含硫醚肽的方法
WO2022194988A2 (en) 2021-03-19 2022-09-22 Heidelberg Pharma Research Gmbh B-lymphocyte specific amatoxin antibody conjugates
CN115385916B (zh) * 2021-07-01 2023-08-15 江苏师范大学 一种手性吲哚啉并吡咯化合物及其合成方法
US20240165257A1 (en) 2022-11-01 2024-05-23 Heidelberg Pharma Research Gmbh Anti-gucy2c antibody and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463151B1 (en) 1990-01-12 1996-06-12 Cell Genesys, Inc. Generation of xenogeneic antibodies
ES2371085T3 (es) 2006-05-27 2011-12-27 Faulstich, Heinz, Dr. Utilización de conjugados de amatoxinas o falotoxinas con macromoléculas para la terapia tumoral y de la inflamación.
ES2621104T3 (es) 2009-04-08 2017-07-03 Faulstich, Heinz, Dr. Componentes de unión a la superficie de células terapéuticas provistos de amatoxina diseñados para terapia de tumores
KR20110140124A (ko) 2009-04-08 2011-12-30 하인즈 파울스티히 암치료용 아미톡신-활성 표적 결합 부위
WO2011018611A1 (en) 2009-08-10 2011-02-17 Ucl Business Plc Reversible covalent linkage of functional molecules
ES2402254T3 (es) * 2010-09-30 2013-04-30 Heidelberg Pharma Ag Conjugados de amatoxinas con ligadores mejorados
EP2497499A1 (en) * 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
EP2684865A1 (en) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
WO2014043403A1 (en) * 2012-09-12 2014-03-20 Agensys, Inc. Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
US20160220687A1 (en) * 2015-02-02 2016-08-04 National Guard Health Affairs Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
SI3268047T1 (sl) * 2015-03-09 2024-02-29 Heidelberg Pharma Research Gmbh Konjugati amatoksin-protitelo
WO2017089607A1 (en) 2015-11-27 2017-06-01 Heidelberg Pharma Gmbh Derivatives of gamma-amanitin

Also Published As

Publication number Publication date
JP7165720B2 (ja) 2022-11-04
CN111051310B (zh) 2022-11-08
MX2020001472A (es) 2020-10-19
US20200181200A1 (en) 2020-06-11
BR112020001345A2 (pt) 2020-08-11
CN111051310A (zh) 2020-04-21
CA3066867A1 (en) 2019-02-14
RU2020105484A (ru) 2021-08-05
KR20200037207A (ko) 2020-04-08
AU2018314668A1 (en) 2020-01-16
WO2019030173A1 (en) 2019-02-14
AU2018314668B2 (en) 2022-06-02
CO2020001259A2 (es) 2020-02-18
EP3665173A1 (en) 2020-06-17
RU2020105484A3 (ko) 2021-09-13
US10961277B2 (en) 2021-03-30
CL2020000304A1 (es) 2020-08-07
JP2020529452A (ja) 2020-10-08
US11702451B2 (en) 2023-07-18
US20210130412A1 (en) 2021-05-06
ZA201908158B (en) 2022-12-21

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