SG11201912224PA - Novel method for synthesizing amanitins - Google Patents

Novel method for synthesizing amanitins

Info

Publication number
SG11201912224PA
SG11201912224PA SG11201912224PA SG11201912224PA SG11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA SG 11201912224P A SG11201912224P A SG 11201912224PA
Authority
SG
Singapore
Prior art keywords
amanitins
synthesizing
novel method
novel
synthesizing amanitins
Prior art date
Application number
SG11201912224PA
Inventor
Christian Lutz
Werner Simon
Susanne Werner-Simon
CHRISTOPH MüLLER
Thorsten Hechler
Michael Kulke
Original Assignee
Heidelberg Pharma Res Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Res Gmbh filed Critical Heidelberg Pharma Res Gmbh
Publication of SG11201912224PA publication Critical patent/SG11201912224PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817Toxins
    • A61K47/6831Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
SG11201912224PA 2017-08-07 2018-08-06 Novel method for synthesizing amanitins SG11201912224PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17185182 2017-08-07
PCT/EP2018/071268 WO2019030173A1 (en) 2017-08-07 2018-08-06 Novel method for synthesizing amanitins

Publications (1)

Publication Number Publication Date
SG11201912224PA true SG11201912224PA (en) 2020-01-30

Family

ID=59579417

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912224PA SG11201912224PA (en) 2017-08-07 2018-08-06 Novel method for synthesizing amanitins

Country Status (14)

Country Link
US (2) US10961277B2 (en)
EP (1) EP3665173A1 (en)
JP (1) JP7165720B2 (en)
KR (1) KR20200037207A (en)
CN (1) CN111051310B (en)
AU (1) AU2018314668B2 (en)
BR (1) BR112020001345A2 (en)
CA (1) CA3066867A1 (en)
CL (1) CL2020000304A1 (en)
CO (1) CO2020001259A2 (en)
MX (1) MX2020001472A (en)
SG (1) SG11201912224PA (en)
WO (1) WO2019030173A1 (en)
ZA (1) ZA201908158B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110997676B (en) 2017-08-07 2022-12-20 海德堡医药研究有限责任公司 Novel method for synthesizing amanitine
JP7335260B2 (en) * 2017-08-18 2023-08-29 バイリ-バイオ(チェンドゥ)ファーマスーティカル シーオー.,エルティーディー. Non-Natural Amanitin Antibody Conjugate
WO2019197654A1 (en) * 2018-04-13 2019-10-17 Heidelberg Pharma Research Gmbh Targeted amatoxin conjugate for the treatment of solid tumors
KR20210102200A (en) * 2018-12-11 2021-08-19 하이델베르크 파마 리서치 게엠베하 Synthesis of (S)-6-hydroxytryptophan and its derivatives
CA3137373A1 (en) * 2019-04-24 2020-10-29 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
WO2021122744A1 (en) * 2019-12-16 2021-06-24 Heidelberg Pharma Research Gmbh Synthesis of amanin and its derivatives
EP4161946A1 (en) * 2020-06-09 2023-04-12 Heidelberg Pharma Research GmbH Method for synthesis of thioether-containing peptides
CN117241832A (en) 2021-03-19 2023-12-15 海德堡医药研究有限责任公司 B lymphocyte-specific amatoxin antibody conjugates
CN115385916B (en) * 2021-07-01 2023-08-15 江苏师范大学 Chiral indoline pyrrole compound and synthesis method thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010741A1 (en) 1990-01-12 1991-07-25 Cell Genesys, Inc. Generation of xenogeneic antibodies
ES2371085T3 (en) 2006-05-27 2011-12-27 Faulstich, Heinz, Dr. USE OF AMATOXIN OR FALOTOXIN CONJUGATES WITH MACROMOLECULES FOR TUMOR THERAPY AND INFLAMMATION.
SI3192529T1 (en) 2009-04-08 2020-07-31 Faulstich, Heinz Dr. Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
EP2416805B1 (en) 2009-04-08 2013-07-24 Heinz Dr. Faulstich Amatoxin antibody conjugates for the treatment of cancer
EP2889624B1 (en) 2009-08-10 2018-10-03 UCL Business PLC Reversible covalent linkage of functional molecules
ES2402254T3 (en) 2010-09-30 2013-04-30 Heidelberg Pharma Ag Amatoxin conjugates with improved linkers
EP2497499A1 (en) 2011-03-10 2012-09-12 Heidelberg Pharma GmbH Amatoxin-conjugates with improved linkages
EP2684865A1 (en) 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Methods for synthesizing amatoxin building block and amatoxins
US20150218220A1 (en) * 2012-09-12 2015-08-06 Brian Alan MENDELSOHN Amatoxin derivatives and cell-permeable conjugates thereof as inhibitors of rna polymerase
US20160220687A1 (en) * 2015-02-02 2016-08-04 National Guard Health Affairs Metalloproteinase-cleavable alpha-amanitin-dendrimer conjugates and method of treating cancer
JP6863900B2 (en) * 2015-03-09 2021-04-21 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング New Amatoxin-Antibody Conjugate
CA3005683A1 (en) 2015-11-27 2017-06-01 Heidelberg Pharma Research Gmbh Derivatives of gamma-amanitin

Also Published As

Publication number Publication date
KR20200037207A (en) 2020-04-08
CN111051310A (en) 2020-04-21
RU2020105484A (en) 2021-08-05
AU2018314668A1 (en) 2020-01-16
ZA201908158B (en) 2022-12-21
US20200181200A1 (en) 2020-06-11
CL2020000304A1 (en) 2020-08-07
RU2020105484A3 (en) 2021-09-13
US10961277B2 (en) 2021-03-30
JP2020529452A (en) 2020-10-08
JP7165720B2 (en) 2022-11-04
US20210130412A1 (en) 2021-05-06
EP3665173A1 (en) 2020-06-17
US11702451B2 (en) 2023-07-18
AU2018314668B2 (en) 2022-06-02
WO2019030173A1 (en) 2019-02-14
MX2020001472A (en) 2020-10-19
CN111051310B (en) 2022-11-08
CO2020001259A2 (en) 2020-02-18
CA3066867A1 (en) 2019-02-14
BR112020001345A2 (en) 2020-08-11

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