SG11201909814WA - Gene therapy - Google Patents
Gene therapyInfo
- Publication number
- SG11201909814WA SG11201909814WA SG11201909814WA SG11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- gene therapy
- milan
- tiget
- monocyte
- Prior art date
Links
- 238000001415 gene therapy Methods 0.000 title abstract 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 6
- 102000006992 Interferon-alpha Human genes 0.000 abstract 2
- 108010047761 Interferon-alpha Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000002540 macrophage Anatomy 0.000 abstract 2
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 abstract 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 abstract 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 abstract 1
- 108091028066 Mir-126 Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A61K35/14—Blood; Artificial blood
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- A61K38/21—Interferons [IFN]
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- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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- C07K—PEPTIDES
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1706410.6A GB201706410D0 (en) | 2017-04-21 | 2017-04-21 | Type 1 interferon gene therapy |
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PCT/EP2018/060238 WO2018193119A1 (en) | 2017-04-21 | 2018-04-20 | Gene therapy |
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SG11202108680XA (en) * | 2019-02-22 | 2021-09-29 | Oncolytics Biotech Inc | T cell repertoire dynamics and oncolytic viral therapy |
US20220362304A1 (en) * | 2019-03-20 | 2022-11-17 | 2Seventy Bio, Inc. | Adoptive cell therapy |
CN112280829B (zh) * | 2020-04-07 | 2023-12-26 | 南方科技大学 | 一种试剂盒、样本标记方法、单细胞测序方法 |
EP4242297A1 (en) * | 2020-11-03 | 2023-09-13 | EdiGene (GuangZhou) Inc. | Cell preparation, use of protein in characterizing hematopoietic stem cells, and method for determining hematopoietic stem cells |
CN114807155A (zh) * | 2021-01-18 | 2022-07-29 | 华东师范大学 | 用于基因编辑的组合物及其应用 |
WO2024068617A1 (en) * | 2022-09-26 | 2024-04-04 | Institut Curie | Myeloid cells expressing il-2 and uses thereof for quick anticancer therapy |
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EP2946014A2 (en) * | 2013-01-17 | 2015-11-25 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
US20180362975A1 (en) * | 2015-12-04 | 2018-12-20 | Novartis Ag | Compositions and methods for immunooncology |
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