SG11201909814WA - Gene therapy - Google Patents
Gene therapyInfo
- Publication number
- SG11201909814WA SG11201909814WA SG11201909814WA SG11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA SG 11201909814W A SG11201909814W A SG 11201909814WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- gene therapy
- milan
- tiget
- monocyte
- Prior art date
Links
- 238000001415 gene therapy Methods 0.000 title abstract 6
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 6
- 102000006992 Interferon-alpha Human genes 0.000 abstract 2
- 108010047761 Interferon-alpha Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000002540 macrophage Anatomy 0.000 abstract 2
- 210000001616 monocyte Anatomy 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 abstract 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 abstract 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 abstract 1
- 108091028066 Mir-126 Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT oimiolollm °nolo Oil mum olom Env oimIE (10) International Publication Number WO 2018/193119 Al (51) International Patent Classification: C12N 5/0789 (2010.01) A61K 38/21 (2006.01) C12N 5/0786 (2010.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) A61K 48/00 (2006.01) A61K 31/405 (2006.01) A61P 35/00 (2006.01) A61K 35/15 (2015.01) (21) International Application Number: PCT/EP2018/060238 (22) International Filing Date: 20 April 2018 (20.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1706410.6 21 April 2017 (21.04.2017) GB 1801511.5 30 January 2018 (30.01.2018) GB (71) Applicants: OSPEDALE SAN RAFFAELE S.R.L. [IT/IT]; Via Olgettina 60, 20132 Milan (IT). FON- DAZIONE TELETHON [IT/IT]; Via Varese 16B, 00185 Rome (IT). (72) Inventors: NALDINI, Luigi; San Raffaele Telethon Insti- tute for Gene Therapy (TIGET), Via Olgettina 58, 20132 Milan (IT). ESCOBAR, Giulia; San Raffaele Telethon In- stitute for Gene Therapy (TIGET), Via Olgettina 58, 20132 Milan (IT). GENTNER, Bernhard Rudolf; San Raffaele Telethon Institute for Gene Therapy (TIGET), Via Olget- tina 58, 20132 Milan (IT). MUCCI, Adele; San Raffaele Telethon Institute for Gene Therapy (TIGET), Via Olgetti- na 58, 20132 Milan (IT). (74) Agent: D YOUNG & CO LLP; 120 Holborn, London EC1N 2DY (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: GENE THERAPY (57) : A hematopoietic stem cell (HSC), a hematopoietic progenitor cell (HPC) a myeloid/monocyte-committed progenitor cell, a macrophage or a monocyte comprising a vector wherein the vector comprises at least one mir-130a and/or mir-126 target sequence operably linked to a nucleotide sequence encoding interferon-alpha (IFNa) for use in treating or preventing a cancer in a patient, wherein the HSC, the HPC, the myeloid/monocyte-committed progenitor cell, the macrophage or the monocyte is used in combination with an immune checkpoint inhibitor and/or a tumor associated antigen (TAA)-specific T-cell.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1706410.6A GB201706410D0 (en) | 2017-04-21 | 2017-04-21 | Type 1 interferon gene therapy |
GBGB1801511.5A GB201801511D0 (en) | 2018-01-30 | 2018-01-30 | Gene therapy |
PCT/EP2018/060238 WO2018193119A1 (en) | 2017-04-21 | 2018-04-20 | Gene therapy |
Publications (1)
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SG11201909814WA true SG11201909814WA (en) | 2019-11-28 |
Family
ID=62165525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SG11201909814W SG11201909814WA (en) | 2017-04-21 | 2018-04-20 | Gene therapy |
Country Status (10)
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US (1) | US20200078408A1 (en) |
EP (1) | EP3612624A1 (en) |
JP (2) | JP7252135B2 (en) |
KR (1) | KR20200020677A (en) |
CN (1) | CN110785488A (en) |
AU (1) | AU2018253959A1 (en) |
BR (1) | BR112019021953A2 (en) |
CA (1) | CA3060145A1 (en) |
SG (1) | SG11201909814WA (en) |
WO (1) | WO2018193119A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2020170215A1 (en) * | 2019-02-22 | 2020-08-27 | Oncolytics Biotech Inc. | T cell repertoire dynamics and oncolytic viral therapy |
WO2020191358A1 (en) * | 2019-03-20 | 2020-09-24 | Bluebird Bio, Inc. | Adoptive cell therapy |
CN112280829B (en) * | 2020-04-07 | 2023-12-26 | 南方科技大学 | Kit, sample marking method and single-cell sequencing method |
CN114460304A (en) * | 2020-11-03 | 2022-05-10 | 广州辑因医疗科技有限公司 | Cell preparation, use of protein in characterization of hematopoietic stem cells and method for determining hematopoietic stem cells |
CN114807155A (en) * | 2021-01-18 | 2022-07-29 | 华东师范大学 | Compositions for gene editing and uses thereof |
WO2024068617A1 (en) * | 2022-09-26 | 2024-04-04 | Institut Curie | Myeloid cells expressing il-2 and uses thereof for quick anticancer therapy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9803351D0 (en) * | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
US10287579B2 (en) * | 2009-04-30 | 2019-05-14 | Ospedale San Raffaele S.R.L. | Gene vector |
AU2013374345A1 (en) * | 2013-01-17 | 2015-08-06 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
BR112018011089A2 (en) * | 2015-12-04 | 2018-12-04 | Intellia Therapeutics Inc | compositions and methods for immuno-oncology |
-
2018
- 2018-04-20 BR BR112019021953-6A patent/BR112019021953A2/en unknown
- 2018-04-20 JP JP2019556929A patent/JP7252135B2/en active Active
- 2018-04-20 EP EP18724470.2A patent/EP3612624A1/en active Pending
- 2018-04-20 CA CA3060145A patent/CA3060145A1/en active Pending
- 2018-04-20 KR KR1020197034111A patent/KR20200020677A/en not_active Application Discontinuation
- 2018-04-20 CN CN201880040639.9A patent/CN110785488A/en active Pending
- 2018-04-20 US US16/604,484 patent/US20200078408A1/en active Pending
- 2018-04-20 AU AU2018253959A patent/AU2018253959A1/en active Pending
- 2018-04-20 SG SG11201909814W patent/SG11201909814WA/en unknown
- 2018-04-20 WO PCT/EP2018/060238 patent/WO2018193119A1/en active Application Filing
-
2023
- 2023-03-23 JP JP2023046113A patent/JP2023078376A/en active Pending
Also Published As
Publication number | Publication date |
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BR112019021953A2 (en) | 2020-07-21 |
CN110785488A (en) | 2020-02-11 |
KR20200020677A (en) | 2020-02-26 |
US20200078408A1 (en) | 2020-03-12 |
JP7252135B2 (en) | 2023-04-04 |
AU2018253959A1 (en) | 2019-11-21 |
EP3612624A1 (en) | 2020-02-26 |
JP2020517261A (en) | 2020-06-18 |
WO2018193119A1 (en) | 2018-10-25 |
JP2023078376A (en) | 2023-06-06 |
CA3060145A1 (en) | 2018-10-25 |
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