SG11201908127WA - Method for producing multispecific antibodies - Google Patents

Method for producing multispecific antibodies

Info

Publication number
SG11201908127WA
SG11201908127WA SG11201908127WA SG11201908127WA SG 11201908127W A SG11201908127W A SG 11201908127WA SG 11201908127W A SG11201908127W A SG 11201908127WA SG 11201908127W A SG11201908127W A SG 11201908127WA
Authority
SG
Singapore
Prior art keywords
penzberg
international
roche
antibody
diagnostics gmbh
Prior art date
Application number
Other languages
English (en)
Inventor
Stefan Seeber
Ulrich Goepfert
Andrea Osterlehner
Hubert Kettenberger
Wolfgang Paul
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201908127WA publication Critical patent/SG11201908127WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
SG11201908127W 2017-03-10 2018-03-07 Method for producing multispecific antibodies SG11201908127WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17160415 2017-03-10
PCT/EP2018/055532 WO2018162517A1 (en) 2017-03-10 2018-03-07 Method for producing multispecific antibodies

Publications (1)

Publication Number Publication Date
SG11201908127WA true SG11201908127WA (en) 2019-10-30

Family

ID=58266981

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908127W SG11201908127WA (en) 2017-03-10 2018-03-07 Method for producing multispecific antibodies

Country Status (18)

Country Link
US (2) US20200216553A1 (ja)
EP (1) EP3592767A1 (ja)
JP (2) JP7021245B2 (ja)
KR (2) KR20210132207A (ja)
CN (1) CN110402253B (ja)
AU (1) AU2018232698B2 (ja)
BR (1) BR112019016970A2 (ja)
CA (1) CA3052357A1 (ja)
CL (1) CL2019002521A1 (ja)
CR (1) CR20190397A (ja)
IL (1) IL268470A (ja)
MA (1) MA48723A (ja)
MX (1) MX2019010575A (ja)
NZ (1) NZ756132A (ja)
PE (1) PE20191360A1 (ja)
RU (1) RU2750721C2 (ja)
SG (1) SG11201908127WA (ja)
WO (1) WO2018162517A1 (ja)

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BRPI1010297A2 (pt) 2009-04-07 2017-06-06 Roche Glycart Ag anticorpos biespecíficos trivalentes.
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AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
EP3856789A4 (en) * 2018-09-28 2022-08-17 Chugai Seiyaku Kabushiki Kaisha ANTIGEN-BINDING MOLECULE COMPRISING A MODIFIED VARIABLE ANTIBODY REGION
CA3130546A1 (en) 2019-03-29 2020-10-08 Tilman Schlothauer Method for the generation of an fcrn expressing cell by targeted integration of multiple expression cassettes in a defined organization
WO2020227206A1 (en) * 2019-05-07 2020-11-12 Amgen Inc. Vectors and expression systems for producing recombinant proteins
MX2021015540A (es) 2019-06-19 2022-02-10 Hoffmann La Roche Metodo para la generacion de una celula que expresa un anticuerpo trivalente mediante la integracion dirigida de multiples casetes de expresion en una organizacion definida.
BR112021025436A2 (pt) 2019-06-19 2022-02-01 Hoffmann La Roche Métodos para produzir um anticorpo biespecífico trivalente, biespecífico bivalente, biespecífico multivalente, para produzir uma célula de mamífero recombinante e para produzir um anticorpo trivalente, ácidos desoxirribonucleicos, usos de um ácido desoxirribonucleico, células de mamífero recombinante, composições e uso de mrna de recombinase cre
AU2020294879A1 (en) 2019-06-19 2021-12-16 F. Hoffmann-La Roche Ag Method for the generation of a bivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization
KR20220010024A (ko) 2019-06-19 2022-01-25 에프. 호프만-라 로슈 아게 Cre mrna를 이용한 표적화된 통합에 의한 단백질 발현 세포의 산출을 위한 방법
WO2020254356A1 (en) 2019-06-19 2020-12-24 F. Hoffmann-La Roche Ag Method for the generation of a multivalent, bispecific antibody expressing cell by targeted integration of multiple expression cassettes in a defined organization

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Also Published As

Publication number Publication date
NZ756132A (en) 2022-02-25
PE20191360A1 (es) 2019-10-01
US20230129340A1 (en) 2023-04-27
JP2020509754A (ja) 2020-04-02
IL268470A (en) 2019-09-26
CA3052357A1 (en) 2018-09-13
EP3592767A1 (en) 2020-01-15
AU2018232698B2 (en) 2020-06-25
US20200216553A1 (en) 2020-07-09
MA48723A (fr) 2020-04-08
KR20210132207A (ko) 2021-11-03
JP2022001059A (ja) 2022-01-06
CL2019002521A1 (es) 2020-01-31
JP7021245B2 (ja) 2022-02-16
RU2019131113A (ru) 2021-04-12
BR112019016970A2 (pt) 2020-04-07
CN110402253B (zh) 2024-01-05
MX2019010575A (es) 2019-10-15
RU2750721C2 (ru) 2021-07-01
WO2018162517A1 (en) 2018-09-13
CR20190397A (es) 2019-09-27
KR20190124270A (ko) 2019-11-04
RU2019131113A3 (ja) 2021-04-12
CN110402253A (zh) 2019-11-01
AU2018232698A1 (en) 2019-08-15

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