SG11201900595YA - Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells - Google Patents
Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cellsInfo
- Publication number
- SG11201900595YA SG11201900595YA SG11201900595YA SG11201900595YA SG11201900595YA SG 11201900595Y A SG11201900595Y A SG 11201900595YA SG 11201900595Y A SG11201900595Y A SG 11201900595YA SG 11201900595Y A SG11201900595Y A SG 11201900595YA SG 11201900595Y A SG11201900595Y A SG 11201900595YA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- vaccinia virus
- pct
- new york
- interest
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 102000040430 polynucleotide Human genes 0.000 title abstract 4
- 108091033319 polynucleotide Proteins 0.000 title abstract 4
- 239000002157 polynucleotide Substances 0.000 title abstract 4
- 241000700618 Vaccinia virus Species 0.000 title abstract 3
- 210000003527 eukaryotic cell Anatomy 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000010276 construction Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 abstract 1
- 229960001225 rifampicin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370009P | 2016-08-02 | 2016-08-02 | |
| PCT/US2017/044688 WO2018026715A1 (en) | 2016-08-02 | 2017-07-31 | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900595YA true SG11201900595YA (en) | 2019-02-27 |
Family
ID=61073907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900595YA SG11201900595YA (en) | 2016-08-02 | 2017-07-31 | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20190169606A1 (pt) |
| EP (1) | EP3494131A4 (pt) |
| JP (2) | JP7128177B2 (pt) |
| KR (1) | KR102449406B1 (pt) |
| CN (1) | CN109563143A (pt) |
| AU (1) | AU2017306062B2 (pt) |
| BR (1) | BR112019001944A2 (pt) |
| CA (1) | CA3032512A1 (pt) |
| IL (1) | IL264343B1 (pt) |
| MX (1) | MX2019001453A (pt) |
| RU (1) | RU2747557C2 (pt) |
| SG (1) | SG11201900595YA (pt) |
| WO (1) | WO2018026715A1 (pt) |
| ZA (1) | ZA201901286B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011011718A (es) | 2009-05-08 | 2012-01-27 | Vaccinex Inc | Anticuerpos anti-cd100 y metodos para su uso. |
| CN110105452A (zh) | 2011-10-11 | 2019-08-09 | 瓦西尼斯公司 | 臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途 |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| DK3013350T3 (da) | 2013-06-25 | 2020-04-14 | Vaccinex Inc | Anvendelse af semaphorin-4D-hæmmende molekyler i kombination med en immunmodulerende terapi for at hæmme tumorvækst og metastaser |
| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| EP4059516A1 (en) | 2016-04-22 | 2022-09-21 | Vaccinex, Inc. | Integral membrane protein display on poxvirus extracellular enveloped virions |
| CN109563143A (zh) * | 2016-08-02 | 2019-04-02 | 瓦西尼斯公司 | 在牛痘病毒/真核细胞中产生多核苷酸文库的改良方法 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0502036B1 (en) | 1989-11-22 | 1995-12-20 | Genentech, Inc. | Latency associated peptide and uses therefor |
| WO1991010741A1 (en) | 1990-01-12 | 1991-07-25 | Cell Genesys, Inc. | Generation of xenogeneic antibodies |
| US5445953A (en) | 1991-08-26 | 1995-08-29 | Immuno Aktiengesellschaft | Direct molecular cloning of a modified poxvirus genome |
| WO1995030018A2 (en) | 1994-04-29 | 1995-11-09 | Immuno Aktiengesellschaft | Recombinant poxviruses with foreign polynucleotides in essential regions |
| US6576754B2 (en) | 1995-11-09 | 2003-06-10 | Dana-Farber Cancer Institute | CD100 antigen and uses therefor |
| US6872518B2 (en) | 1997-09-22 | 2005-03-29 | University Of Rochester | Methods for selecting polynucleotides encoding T cell epitopes |
| EP1137769B1 (en) | 1998-11-10 | 2008-09-03 | University Of Rochester | Methods for the generation of dna libraries |
| EP1268763A2 (en) * | 2000-03-28 | 2003-01-02 | University Of Rochester | Methods of producing a library and methods of selecting polynucleotides |
| CA2341356C (en) | 2000-04-14 | 2011-10-11 | Transgene S.A. | Poxvirus with targeted infection specificity |
| DE60126130T2 (de) * | 2000-11-17 | 2007-10-18 | The University Of Rochester | In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen |
| AU2002338446A1 (en) * | 2001-01-23 | 2002-11-05 | University Of Rochester Medical Center | Methods of producing or identifying intrabodies in eukaryotic cells |
| US20020192675A1 (en) * | 2001-02-02 | 2002-12-19 | The University Of Rochester | Methods of identifying regulator molecules |
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| EP1413316A1 (en) | 2002-09-27 | 2004-04-28 | Bruno Robert | Bifunctional conjugates or fusion proteins |
| EP1442749A1 (en) | 2003-01-31 | 2004-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of anti-CD100 antibodies for the treatment and the diagnosis of inflammatory disorder affecting the central nervous system |
| JP5042631B2 (ja) | 2003-12-04 | 2012-10-03 | バクシネックス インコーポレーティッド | アポトーシス腫瘍細胞上に露出した細胞内抗原をターゲッティングすることによって腫瘍細胞を死滅させる方法 |
| US20050266425A1 (en) | 2003-12-31 | 2005-12-01 | Vaccinex, Inc. | Methods for producing and identifying multispecific antibodies |
| WO2006026389A2 (en) | 2004-08-27 | 2006-03-09 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| US8022043B2 (en) | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
| AU2006232310B9 (en) * | 2005-04-06 | 2011-07-21 | Ibc Pharmaceuticals, Inc. | Improved stably tethered structures of defined compositions with multiple functions or binding specificities |
| RU2311927C2 (ru) * | 2005-08-15 | 2007-12-10 | Федеральное государственное унитарное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" | КОМБИНАТОРНАЯ ФАГМИДНАЯ БИБЛИОТЕКА ОДНОЦЕПОЧЕЧНЫХ АНТИТЕЛ ЧЕЛОВЕКА, ОБОГАЩЕННАЯ АНТИТЕЛАМИ ПРОТИВ ВИРУСА ОСПОВАКЦИНЫ, РЕКОМБИНАНТНАЯ ФАГМИДНАЯ ДНК pHEN-2A8, СОДЕРЖАЩАЯ УНИКАЛЬНЫЙ ГЕН ОДНОЦЕПОЧЕЧНОГО АНТИТЕЛА ЧЕЛОВЕКА, СПОСОБНОГО НЕЙТРАЛИЗОВАТЬ ВИРУС ОСПОВАКЦИНЫ И ВИРУС ОСПЫ КОРОВ, И ИСКУССТВЕННОЕ ОДНОЦЕПОЧЕЧНОЕ АНТИТЕЛО ЧЕЛОВЕКА 2A8, СПОСОБНОЕ НЕЙТРАЛИЗОВАТЬ ВИРУС ОСПОВАКЦИНЫ И ВИРУС ОСПЫ КОРОВ |
| US7858599B2 (en) | 2005-12-30 | 2010-12-28 | Hander Robert W | Enhancement of urogenital function |
| RU2317330C2 (ru) * | 2006-01-16 | 2008-02-20 | Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pcL37, КОДИРУЮЩАЯ ПОЛИПЕПТИД СО СВОЙСТВАМИ ЛЕГКОЙ ЦЕПИ АНТИТЕЛА ЧЕЛОВЕКА ПРОТИВ ВИРУСА ОСПОВАКЦИНЫ, РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pcH37, КОДИРУЮЩАЯ ПОЛИПЕПТИД СО СВОЙСТВАМИ ТЯЖЕЛОЙ ЦЕПИ УКАЗАННОГО АНТИТЕЛА, И ИХ ПРИМЕНЕНИЕ |
| CN101020055B (zh) * | 2006-02-16 | 2012-08-08 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于复制型痘苗病毒载体的sars疫苗 |
| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| DE602008004296D1 (de) | 2007-02-14 | 2011-02-17 | Vaccinex Inc | Humanisierte anti-cd100-antikörper |
| JP5357782B2 (ja) | 2007-02-21 | 2013-12-04 | バクシネックス インコーポレーティッド | 抗原負荷ＣＤ１ｄ分子によるＮＫＴ細胞活性の調節 |
| NZ586544A (en) | 2007-12-26 | 2012-07-27 | Vaccinex Inc | Anti-c35 antibody in combination with an ani-her2 antibody in cancer therapies and methods |
| US8535687B2 (en) | 2008-05-28 | 2013-09-17 | The Trustees Of The University Of Pennsylvania | Smallpox DNA vaccine and the antigens therein that elicit an immune response |
| US20100081575A1 (en) | 2008-09-22 | 2010-04-01 | Robert Anthony Williamson | Methods for creating diversity in libraries and libraries, display vectors and methods, and displayed molecules |
| WO2010081026A1 (en) | 2009-01-08 | 2010-07-15 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof |
| MX2011011718A (es) | 2009-05-08 | 2012-01-27 | Vaccinex Inc | Anticuerpos anti-cd100 y metodos para su uso. |
| AU2011226103C1 (en) | 2010-03-10 | 2016-04-28 | Genmab A/S | Monoclonal antibodies against c-Met |
| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| WO2011140249A2 (en) | 2010-05-04 | 2011-11-10 | Five Prime Therapeutics, Inc. | Antibodies that bind csf1r |
| US8834883B2 (en) | 2010-06-14 | 2014-09-16 | Vaccinex, Inc. | Anti-VEGF antibodies and uses thereof |
| WO2012006342A2 (en) | 2010-07-07 | 2012-01-12 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide-like glycolipid-associated bacterial vaccines and uses thereof |
| EP2611832B1 (en) | 2010-09-02 | 2017-11-29 | Vaccinex, Inc. | Anti-cxcl13 antibodies and methods of using the same |
| CN103945868B (zh) | 2011-05-13 | 2016-10-26 | 国立大学法人东京医科齿科大学 | 骨生成促进剂 |
| CN110105452A (zh) | 2011-10-11 | 2019-08-09 | 瓦西尼斯公司 | 臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途 |
| US8790652B2 (en) | 2011-12-06 | 2014-07-29 | Vaccinex, Inc. | Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis |
| US9890213B2 (en) | 2012-03-02 | 2018-02-13 | Vaccinex, Inc. | Methods for the treatment of B cell-mediated inflammatory diseases |
| US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| KR102176962B1 (ko) | 2013-01-31 | 2020-11-10 | 백시넥스 인코포레이티드 | 면역글로불린 a 수준을 증가시키기 위한 방법 |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| DK3013350T3 (da) | 2013-06-25 | 2020-04-14 | Vaccinex Inc | Anvendelse af semaphorin-4D-hæmmende molekyler i kombination med en immunmodulerende terapi for at hæmme tumorvækst og metastaser |
| US9890201B2 (en) * | 2013-08-02 | 2018-02-13 | International Park Of Creativity | Biological devices and methods of use thereof for the study and control of alzheimer's disease |
| NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| EP4059516A1 (en) | 2016-04-22 | 2022-09-21 | Vaccinex, Inc. | Integral membrane protein display on poxvirus extracellular enveloped virions |
| CN109563143A (zh) * | 2016-08-02 | 2019-04-02 | 瓦西尼斯公司 | 在牛痘病毒/真核细胞中产生多核苷酸文库的改良方法 |
| US20190383836A1 (en) | 2017-02-22 | 2019-12-19 | Vaccinex, Inc. | Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases |
| DK3600419T5 (en) | 2017-03-20 | 2023-11-13 | Vaccinex Inc | Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent |
| AU2018261947A1 (en) | 2017-05-05 | 2019-11-07 | Vaccinex, Inc. | Human anti-semaphorin 4D antibody |
-
2017
- 2017-07-31 CN CN201780047905.6A patent/CN109563143A/zh active Pending
- 2017-07-31 BR BR112019001944-8A patent/BR112019001944A2/pt unknown
- 2017-07-31 AU AU2017306062A patent/AU2017306062B2/en active Active
- 2017-07-31 SG SG11201900595YA patent/SG11201900595YA/en unknown
- 2017-07-31 RU RU2019105695A patent/RU2747557C2/ru active
- 2017-07-31 MX MX2019001453A patent/MX2019001453A/es unknown
- 2017-07-31 US US16/320,950 patent/US20190169606A1/en not_active Abandoned
- 2017-07-31 EP EP17837472.4A patent/EP3494131A4/en active Pending
- 2017-07-31 IL IL264343A patent/IL264343B1/en unknown
- 2017-07-31 JP JP2019505498A patent/JP7128177B2/ja active Active
- 2017-07-31 CA CA3032512A patent/CA3032512A1/en active Pending
- 2017-07-31 KR KR1020197005952A patent/KR102449406B1/ko active IP Right Grant
- 2017-07-31 WO PCT/US2017/044688 patent/WO2018026715A1/en unknown
-
2019
- 2019-02-28 ZA ZA2019/01286A patent/ZA201901286B/en unknown
- 2019-04-15 US US16/384,078 patent/US10640765B2/en active Active
-
2020
- 2020-04-28 US US16/860,217 patent/US20200299683A1/en not_active Abandoned
-
2022
- 2022-04-19 JP JP2022068581A patent/JP2022109946A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN109563143A (zh) | 2019-04-02 |
| ZA201901286B (en) | 2023-05-31 |
| AU2017306062B2 (en) | 2021-12-09 |
| AU2017306062A1 (en) | 2019-02-07 |
| EP3494131A1 (en) | 2019-06-12 |
| RU2019105695A3 (pt) | 2020-11-02 |
| KR20190034304A (ko) | 2019-04-01 |
| JP2019524126A (ja) | 2019-09-05 |
| US20190169606A1 (en) | 2019-06-06 |
| US10640765B2 (en) | 2020-05-05 |
| KR102449406B1 (ko) | 2022-09-29 |
| IL264343A (en) | 2019-02-28 |
| MX2019001453A (es) | 2019-06-20 |
| US20200299683A1 (en) | 2020-09-24 |
| RU2747557C2 (ru) | 2021-05-06 |
| JP7128177B2 (ja) | 2022-08-30 |
| US20190241889A1 (en) | 2019-08-08 |
| CA3032512A1 (en) | 2018-02-08 |
| BR112019001944A2 (pt) | 2019-05-07 |
| EP3494131A4 (en) | 2020-04-15 |
| JP2022109946A (ja) | 2022-07-28 |
| RU2019105695A (ru) | 2020-09-07 |
| IL264343B1 (en) | 2024-01-01 |
| WO2018026715A1 (en) | 2018-02-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201900595YA (en) | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells | |
| SG11201810527TA (en) | Methods and apparatus that increase sequencing-by-binding efficiency | |
| SG11201907912YA (en) | An appliance operation signal processing system and method | |
| SG11201807369UA (en) | System and method for beam adjustment request | |
| SG11201908940UA (en) | Isoquinolines as inhibitors of hpk1 | |
| SG11201910101SA (en) | Alphavirus neoantigen vectors | |
| SG11201807389XA (en) | System and method for beam management | |
| SG11201807025SA (en) | Crispr/cas systems for c-1 fixing bacteria | |
| SG11201906235YA (en) | Narrowband time-division duplex frame structure for narrowband communications | |
| SG11201804372PA (en) | Tracking and manipulating cellular rna via nuclear delivery of crispr/cas9 | |
| SG11201803169WA (en) | Cellulase variants and polynucleotides encoding same | |
| SG11201907653QA (en) | Compositions and methods for enhanced gene expression | |
| SG11201806398YA (en) | Optimized factor viii genes | |
| SG11201903012RA (en) | Anti-c1s antibodies and methods of use thereof | |
| SG11201909126XA (en) | In-ground enclosure system | |
| SG11201907383QA (en) | Systems and methods for vehicle sharing service | |
| SG11201810522UA (en) | Anti-cd40 antibodies and their uses | |
| SG11201906238TA (en) | Split sector level sweep using beamforming refinement frames | |
| SG11201909618TA (en) | Compositions and methods for library construction and sequence analysis | |
| SG11201811408PA (en) | Adoptive cell transfer and oncolytic virus combination therapy | |
| SG11201908456VA (en) | Linker units and molecular constructs comprising same | |
| SG11201907434RA (en) | Compositions and methods for immunooncology | |
| SG11201808675VA (en) | Method and kit for the generation of dna libraries for massively parallel sequencing | |
| SG11201811409UA (en) | Systems and methods for determining combinative service requesters | |
| SG11201807325UA (en) | Optimizing range of aircraft docking system |