SG11201811280QA - Improved pharmacokinetic assays for immunoglobulin single variable domains - Google Patents
Improved pharmacokinetic assays for immunoglobulin single variable domainsInfo
- Publication number
- SG11201811280QA SG11201811280QA SG11201811280QA SG11201811280QA SG11201811280QA SG 11201811280Q A SG11201811280Q A SG 11201811280QA SG 11201811280Q A SG11201811280Q A SG 11201811280QA SG 11201811280Q A SG11201811280Q A SG 11201811280QA SG 11201811280Q A SG11201811280Q A SG 11201811280QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- variable domains
- single variable
- immunoglobulin single
- pct
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 3
- 102000018358 immunoglobulin Human genes 0.000 title abstract 3
- 238000002732 pharmacokinetic assay Methods 0.000 title abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/549—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662353784P | 2016-06-23 | 2016-06-23 | |
| PCT/EP2017/065219 WO2017220645A1 (en) | 2016-06-23 | 2017-06-21 | Improved pharmacokinetic assays for immunoglobulin single variable domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201811280QA true SG11201811280QA (en) | 2019-01-30 |
Family
ID=59313197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201811280QA SG11201811280QA (en) | 2016-06-23 | 2017-06-21 | Improved pharmacokinetic assays for immunoglobulin single variable domains |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20190195866A1 (de) |
| EP (2) | EP3475699B1 (de) |
| JP (1) | JP7150618B2 (de) |
| KR (1) | KR102374912B1 (de) |
| CN (1) | CN109313183B (de) |
| AU (1) | AU2017281421A1 (de) |
| BR (1) | BR112018076569A2 (de) |
| CA (1) | CA3029133C (de) |
| ES (1) | ES2926014T3 (de) |
| IL (1) | IL263704B1 (de) |
| MX (1) | MX2018016413A (de) |
| PL (1) | PL3475699T3 (de) |
| PT (1) | PT3475699T (de) |
| RU (1) | RU2765809C2 (de) |
| SG (1) | SG11201811280QA (de) |
| WO (1) | WO2017220645A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190154669A1 (en) * | 2017-11-20 | 2019-05-23 | Vector Laboratories, Inc. | Methods and systems for species-on-species immunoassay detection |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| EP2390268B1 (de) | 2002-11-08 | 2017-11-01 | Ablynx N.V. | Gegen Tumornekrosefaktor-alpha gerichtete Einzeldomänen-Antikörper und Verwendungen dafür |
| EP2390270A1 (de) | 2003-01-10 | 2011-11-30 | Ablynx N.V. | Therapeutische Polypeptide, Homologe davon, Fragmente davon und Verwendung bei modulierender plättchenvermittelter Aggregation |
| CN101133084A (zh) | 2004-12-02 | 2008-02-27 | 多曼蒂斯有限公司 | 采用白细胞介素-1ⅰ型受体拮抗剂治疗呼吸道疾病的方法 |
| MX363423B (es) | 2005-05-18 | 2019-03-22 | Ablynx Nv | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
| MX2007014564A (es) | 2005-05-20 | 2008-02-07 | Ablynx Nv | Anticuerpos de vhh de dominio unico contra el factor de von willebrand. |
| CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| EP1957537A2 (de) | 2005-12-01 | 2008-08-20 | Domantis Limited | Kompetitive domänenantikörperformate, die an den interleukin-1-rezeptor vom typ 1 binden |
| CA2632866A1 (en) | 2005-12-01 | 2007-06-07 | Domantis Limited | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
| FR2894741B1 (fr) | 2005-12-08 | 2009-12-04 | Centre Nat Etd Spatiales | Chaine de reception par satellite |
| EP1976991A1 (de) | 2006-01-24 | 2008-10-08 | Domantis Limited | Fusionsproteine mit natürlichen verbindungen |
| WO2007118670A1 (en) * | 2006-04-14 | 2007-10-25 | Ablynx N.V. | Dp-78-like nanobodies |
| CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| WO2012130874A1 (en) * | 2011-03-28 | 2012-10-04 | Ablynx Nv | Bispecific anti-cxcr7 immunoglobulin single variable domains |
| JP2010527005A (ja) * | 2007-05-07 | 2010-08-05 | ワイス・エルエルシー | 抗炭水化物抗体によって生じるイムノアッセイにおける妨害の除去 |
| CA2706425A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| WO2009095489A2 (en) | 2008-02-01 | 2009-08-06 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| DE102008023620A1 (de) | 2008-05-15 | 2009-11-19 | Mettler-Toledo (Albstadt) Gmbh | Funktionseinheit mit einer aufrufbaren Funktion und Verfahren zu deren Aufruf |
| BRPI0911984A2 (pt) | 2008-05-16 | 2016-09-20 | Ablynx Nv | sequências de aminoácidos direncionadas contra cxcr4 e outros compostos gpcrs compreendendo os mesmos |
| WO2010130832A2 (en) | 2009-05-15 | 2010-11-18 | Ablynx N.V. | Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions |
| NZ597314A (en) | 2009-06-05 | 2013-07-26 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
| US8962807B2 (en) * | 2009-12-14 | 2015-02-24 | Ablynx N.V. | Single variable domain antibodies against OX40L, constructs and therapeutic use |
| WO2012042026A1 (en) * | 2010-09-30 | 2012-04-05 | Ablynx Nv | Biological materials related to c-met |
| KR20220114104A (ko) * | 2011-06-23 | 2022-08-17 | 아블린쓰 엔.브이. | 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법 |
| PL2723771T3 (pl) | 2011-06-23 | 2020-04-30 | Ablynx Nv | Białka wiążące albuminy surowicy |
| FR2979099B1 (fr) | 2011-08-16 | 2014-02-28 | Oreal | Tete de distribution de produit pour un recipient et dispositif de distribution associe |
| CA2845029A1 (en) * | 2011-08-17 | 2013-02-21 | Glaxo Group Limited | Modified proteins and peptides |
| CN103293299B (zh) * | 2012-02-24 | 2016-06-08 | 珀金埃尔默医学诊断产品（上海）有限公司 | 拓宽双抗体夹心免疫检测浓度范围的方法及其试剂盒 |
| CN103884842A (zh) * | 2014-04-03 | 2014-06-25 | 王少雄 | 针对elisa检测用特异性抗体对的筛选方法 |
| BR122018009619B1 (pt) | 2014-05-16 | 2024-01-02 | Ablynx N.V | Domínios variáveis de imunoglobulina aperfeiçoados |
| CN104597232B (zh) * | 2014-12-03 | 2017-05-03 | 中国科学院理化技术研究所 | 一种可扩展检测范围的捕获抗体竞争夹心免疫检测方法及生物传感器 |
-
2017
- 2017-06-21 PL PL17737492.3T patent/PL3475699T3/pl unknown
- 2017-06-21 SG SG11201811280QA patent/SG11201811280QA/en unknown
- 2017-06-21 ES ES17737492T patent/ES2926014T3/es active Active
- 2017-06-21 EP EP17737492.3A patent/EP3475699B1/de active Active
- 2017-06-21 MX MX2018016413A patent/MX2018016413A/es unknown
- 2017-06-21 RU RU2019101609A patent/RU2765809C2/ru active
- 2017-06-21 EP EP22178896.1A patent/EP4119944A1/de not_active Withdrawn
- 2017-06-21 CA CA3029133A patent/CA3029133C/en active Active
- 2017-06-21 AU AU2017281421A patent/AU2017281421A1/en active Pending
- 2017-06-21 KR KR1020197002311A patent/KR102374912B1/ko active IP Right Grant
- 2017-06-21 BR BR112018076569A patent/BR112018076569A2/pt unknown
- 2017-06-21 JP JP2018567281A patent/JP7150618B2/ja active Active
- 2017-06-21 IL IL263704A patent/IL263704B1/en unknown
- 2017-06-21 WO PCT/EP2017/065219 patent/WO2017220645A1/en unknown
- 2017-06-21 CN CN201780038584.3A patent/CN109313183B/zh active Active
- 2017-06-21 PT PT177374923T patent/PT3475699T/pt unknown
- 2017-06-21 US US16/310,291 patent/US20190195866A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN109313183B (zh) | 2022-10-21 |
| EP3475699A1 (de) | 2019-05-01 |
| MX2018016413A (es) | 2019-05-09 |
| CA3029133C (en) | 2024-04-30 |
| RU2019101609A3 (de) | 2020-07-23 |
| AU2017281421A1 (en) | 2019-01-24 |
| CN109313183A (zh) | 2019-02-05 |
| EP4119944A1 (de) | 2023-01-18 |
| WO2017220645A1 (en) | 2017-12-28 |
| US20190195866A1 (en) | 2019-06-27 |
| JP2019522796A (ja) | 2019-08-15 |
| IL263704A (en) | 2019-01-31 |
| PL3475699T3 (pl) | 2022-09-26 |
| KR102374912B1 (ko) | 2022-03-16 |
| IL263704B1 (en) | 2024-05-01 |
| RU2019101609A (ru) | 2020-07-23 |
| KR20190020806A (ko) | 2019-03-04 |
| RU2765809C2 (ru) | 2022-02-03 |
| CA3029133A1 (en) | 2017-12-28 |
| BR112018076569A2 (pt) | 2019-04-02 |
| EP3475699B1 (de) | 2022-07-06 |
| JP7150618B2 (ja) | 2022-10-11 |
| ES2926014T3 (es) | 2022-10-21 |
| PT3475699T (pt) | 2022-08-30 |
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