SG11201810611YA - Coumarin compounds and their uses as fluorescent labels - Google Patents

Coumarin compounds and their uses as fluorescent labels

Info

Publication number
SG11201810611YA
SG11201810611YA SG11201810611YA SG11201810611YA SG11201810611YA SG 11201810611Y A SG11201810611Y A SG 11201810611YA SG 11201810611Y A SG11201810611Y A SG 11201810611YA SG 11201810611Y A SG11201810611Y A SG 11201810611YA SG 11201810611Y A SG11201810611Y A SG 11201810611YA
Authority
SG
Singapore
Prior art keywords
international
rule
chesterford
fluorescent labels
pct
Prior art date
Application number
SG11201810611YA
Other languages
English (en)
Inventor
Nikolai Romanov
Original Assignee
Illumina Cambridge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Cambridge Ltd filed Critical Illumina Cambridge Ltd
Publication of SG11201810611YA publication Critical patent/SG11201810611YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/02—Coumarine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201810611YA 2016-12-22 2017-12-15 Coumarin compounds and their uses as fluorescent labels SG11201810611YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662438006P 2016-12-22 2016-12-22
PCT/EP2017/083128 WO2018114710A1 (fr) 2016-12-22 2017-12-15 Composés coumarines et leurs utilisations en tant que marqueurs fluorescents

Publications (1)

Publication Number Publication Date
SG11201810611YA true SG11201810611YA (en) 2018-12-28

Family

ID=60765630

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810611YA SG11201810611YA (en) 2016-12-22 2017-12-15 Coumarin compounds and their uses as fluorescent labels

Country Status (11)

Country Link
US (4) US10214768B2 (fr)
EP (2) EP3559004B1 (fr)
JP (1) JP2020504074A (fr)
KR (1) KR102512190B1 (fr)
CN (1) CN109476674B (fr)
AU (2) AU2017379315B2 (fr)
CA (1) CA3025880C (fr)
ES (1) ES2954284T3 (fr)
IL (1) IL263358B (fr)
SG (1) SG11201810611YA (fr)
WO (1) WO2018114710A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018114710A1 (fr) 2016-12-22 2018-06-28 Illumina Cambridge Limited Composés coumarines et leurs utilisations en tant que marqueurs fluorescents
HUE066335T2 (hu) 2018-10-05 2024-07-28 Annapurna Bio Inc Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére
NL2023327B1 (en) * 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
WO2020178231A1 (fr) * 2019-03-01 2020-09-10 Illumina, Inc. Détection fluorescente multiplexée d'analytes
CN112794857B (zh) * 2019-11-13 2023-09-19 湖南超亟检测技术有限责任公司 一种可用于亚铁离子检测的荧光探针及制备和应用
AU2020389779A1 (en) 2019-11-27 2022-05-26 Illumina Cambridge Limited Cyclooctatetraene containing dyes and compositions
US20220195517A1 (en) * 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195196A1 (en) * 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
CN114671843B (zh) * 2020-12-24 2023-07-04 郑州思昆生物工程有限公司 一种荧光化合物、荧光修饰核苷酸、试剂盒
AU2022277632A1 (en) 2021-05-20 2023-11-09 Illumina Cambridge Limited Compositions and methods for sequencing by synthesis
US20230304086A1 (en) 2022-03-28 2023-09-28 Illumina Cambridge Limited Labeled avidin and methods for sequencing
US20230314322A1 (en) * 2022-03-29 2023-10-05 Illumina, Inc. Systems and methods of sequencing polynucleotides
AU2023244351A1 (en) 2022-03-31 2024-01-18 Illumina, Inc. Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis
US20230357845A1 (en) 2022-03-31 2023-11-09 Illumina, Inc. Compositions and methods for improving sequencing signals
WO2023232829A1 (fr) 2022-05-31 2023-12-07 Illumina, Inc Compositions et procédés de séquençage d'acides nucléiques
WO2024068889A2 (fr) 2022-09-30 2024-04-04 Illumina, Inc. Compositions et procédés de réduction de photolésions pendant le séquençage
AU2023409138A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
WO2024137774A1 (fr) 2022-12-22 2024-06-27 Illumina, Inc. Compositions de catalyseur au palladium et procédés de séquençage par synthèse
US20240271206A1 (en) 2022-12-27 2024-08-15 Illumina, Inc. Methods of sequencing using 3' allyl blocked nucleotides
US20240327909A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2126811A1 (en) * 1971-05-29 1972-12-14 Basf Ag Fluorescent pigments dyes - of the coumarin series for synthetic fibres and plastics
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
JPH0743896A (ja) * 1993-07-28 1995-02-14 Toyobo Co Ltd 光重合性組成物
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
AU6846698A (en) 1997-04-01 1998-10-22 Glaxo Group Limited Method of nucleic acid amplification
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6093518A (en) * 1998-02-09 2000-07-25 Kansai Paint Co., Ltd. Visible laser-curable composition
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
IL141148A0 (en) 1998-07-30 2002-02-10 Solexa Ltd Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6391937B1 (en) 1998-11-25 2002-05-21 Motorola, Inc. Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
AU2001279244A1 (en) 2000-08-09 2002-02-18 Motorola, Inc. The use and evaluation of a (2+2) photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
JP4837174B2 (ja) * 2001-02-02 2011-12-14 株式会社林原生物化学研究所 クマリン誘導体およびその製造方法、それを利用した発光剤、発光素子
DE10160524A1 (de) * 2001-12-05 2003-06-26 Dyomics Gmbh Neue Fluoreszenzmarker mit großem Stokes-Shift
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds
DK3363809T3 (da) 2002-08-23 2020-05-04 Illumina Cambridge Ltd Modificerede nukleotider til polynukleotidsekvensering
DK3147292T3 (en) 2002-08-23 2018-12-03 Illumina Cambridge Ltd LABELED NUCLEOTIDES
US7563907B2 (en) * 2002-12-05 2009-07-21 Dyomics Gmbh Compounds based on polymethines
DE10356130A1 (de) * 2003-11-28 2005-06-23 Dyomics Gmbh Neue Polymethinfarbstoffe auf Cumarin-Basis mit einstellbarem Stokes-Shift
US6727362B1 (en) * 2003-06-19 2004-04-27 Labeltek Inc. Coumarin derivatives and an electroluminescent (EL) device using the coumarin derivatives
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays
US20110059865A1 (en) 2004-01-07 2011-03-10 Mark Edward Brennan Smith Modified Molecular Arrays
WO2006026368A2 (fr) * 2004-08-25 2006-03-09 The Trustees Of Collumbia University In The City Of New York Mise au point de substrats fluorogenes destines aux monoamine oxydases (mao-a and mao-b)
JP4990886B2 (ja) 2005-05-10 2012-08-01 ソレックサ リミテッド 改良ポリメラーゼ
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
USRE49362E1 (en) 2006-05-18 2023-01-10 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
DE102008018132A1 (de) * 2008-04-09 2009-10-15 Henkel Ag & Co. Kgaa Kationische Direktzieher und Mittel zum Färben von keratinhaltigen Fasern
EP2370596B1 (fr) * 2008-12-01 2017-06-07 QIAGEN GmbH Nouvelle combinaison de colorants fluorescents pour la détection d'acides nucléiques
WO2010074325A1 (fr) * 2008-12-25 2010-07-01 Canon Kabushiki Kaisha Composition de marquage pour tissu intra-oculaire, procédé de marquage de tissu intra-oculaire, et procédé de criblage
CN101851505B (zh) * 2010-06-09 2013-02-27 深圳丹邦投资集团有限公司 一种香豆素类有机电致荧光材料及其合成方法
WO2012152698A1 (fr) * 2011-05-06 2012-11-15 Qiagen Gmbh Procédés de séquençage, d'amplification et de détection d'acides nucléiques comprenant une amorce marquée en interne
US9453258B2 (en) 2011-09-23 2016-09-27 Illumina, Inc. Methods and compositions for nucleic acid sequencing
WO2013056720A1 (fr) * 2011-10-18 2013-04-25 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Colorants fluorescents comportant des groupes hydroxyméthyle phosphorylés et leur utilisation en microscopie photonique et dans des techniques d'imagerie
JP6174881B2 (ja) * 2012-04-04 2017-08-02 住友化学株式会社 着色硬化性樹脂組成物
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
CN105263918B (zh) * 2013-03-08 2018-05-18 伊鲁米纳剑桥有限公司 罗丹明化合物及其作为荧光标记物的用途
EP2970356B1 (fr) 2013-03-15 2018-05-30 Illumina Cambridge Limited Nucleosides et nucleotides modifies
CN105218538B (zh) * 2015-09-24 2017-04-26 四川大学 取代的香豆素‑吡啶衍生物及其制备方法和用途
WO2018114710A1 (fr) * 2016-12-22 2018-06-28 Illumina Cambridge Limited Composés coumarines et leurs utilisations en tant que marqueurs fluorescents

Also Published As

Publication number Publication date
AU2017379315B2 (en) 2022-04-14
EP4257596A3 (fr) 2023-12-06
EP3559004A1 (fr) 2019-10-30
JP2020504074A (ja) 2020-02-06
AU2022204153A1 (en) 2022-06-30
US20180201981A1 (en) 2018-07-19
ES2954284T3 (es) 2023-11-21
US20190185918A1 (en) 2019-06-20
US20210155977A1 (en) 2021-05-27
US10907196B2 (en) 2021-02-02
US11371078B2 (en) 2022-06-28
EP3559004B1 (fr) 2023-07-05
EP4257596A2 (fr) 2023-10-11
US10214768B2 (en) 2019-02-26
AU2017379315A1 (en) 2018-12-13
IL263358A (en) 2018-12-31
CN109476674A (zh) 2019-03-15
IL263358B (en) 2020-06-30
AU2022204153B2 (en) 2024-01-18
CA3025880A1 (fr) 2018-06-28
NZ748730A (en) 2021-08-27
NZ778462A (en) 2024-02-23
WO2018114710A1 (fr) 2018-06-28
US10533211B2 (en) 2020-01-14
CA3025880C (fr) 2020-01-28
KR20190095873A (ko) 2019-08-16
CN109476674B (zh) 2021-12-10
KR102512190B1 (ko) 2023-03-21
US20200216882A1 (en) 2020-07-09

Similar Documents

Publication Publication Date Title
SG11201810611YA (en) Coumarin compounds and their uses as fluorescent labels
SG11201810633WA (en) New fluorescent dyes and their uses as biomarkers
SG11201900746RA (en) Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions
SG11201809913PA (en) Methods for detecting target nucleic acids in a sample
SG11201909918XA (en) Compositions and methods for improving sample identification in indexed nucleic acid libraries
SG11201908820VA (en) Novel heterocyclic derivatives useful as shp2 inhibitors
SG11201907162TA (en) Methods for cell-type specific profiling to identify drug targets
SG11201810983PA (en) Novel heterocyclic derivatives useful as shp2 inhibitors
SG11201908719QA (en) Biomarkers and car t cell therapies with enhanced efficacy
SG11201807069XA (en) Nucleic acid sequencing method and system employing enhanced detection of nucleotide-specific ternary complex formation
SG11201810003UA (en) Using programmable dna binding proteins to enhance targeted genome modification
SG11201909916YA (en) Compositions and methods for improving sample identification in indexed nucleic acid libraries
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201906553TA (en) Methods and reagents for synthesising polynucleotide molecules
SG11201806758VA (en) Vcn enhancer compositions and methods of using the same
SG11201908549RA (en) Automated quality control and spectral error correction for sample analysis instruments
SG11201908743SA (en) Methods and compositions for modulation of immune cells
SG11201909011PA (en) Niraparib compositions
SG11201903771XA (en) Binding molecules specific for asct2 and uses thereof
SG11201903139SA (en) Methods for expression profile classification
SG11201805115PA (en) Detection and quantification of target nucleic acid sequence of a microorganism
SG11201408451WA (en) Use of vacuum chucks to hold a wafer or wafer sub-stack
SG11201908456VA (en) Linker units and molecular constructs comprising same
SG11201807596YA (en) Gitr antibodies, methods, and uses
SG11201808992UA (en) Compositions and methods for the detection of host cell proteins