SG11201807124PA - Surface enhanced raman spectroscopy (sers) microfluidics biosensor for detecting single and/or multiple analytes - Google Patents

Surface enhanced raman spectroscopy (sers) microfluidics biosensor for detecting single and/or multiple analytes

Info

Publication number
SG11201807124PA
SG11201807124PA SG11201807124PA SG11201807124PA SG11201807124PA SG 11201807124P A SG11201807124P A SG 11201807124PA SG 11201807124P A SG11201807124P A SG 11201807124PA SG 11201807124P A SG11201807124P A SG 11201807124PA SG 11201807124P A SG11201807124P A SG 11201807124PA
Authority
SG
Singapore
Prior art keywords
sers
singapore
international
biosensor
raman spectroscopy
Prior art date
Application number
SG11201807124PA
Other languages
English (en)
Inventor
Malini Olivo
Jayakumar Perumal
Ghayathri Balasundaram
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201807124PA publication Critical patent/SG11201807124PA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/058—Flat flow cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Fluid Mechanics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
SG11201807124PA 2016-03-23 2017-03-23 Surface enhanced raman spectroscopy (sers) microfluidics biosensor for detecting single and/or multiple analytes SG11201807124PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201602281Y 2016-03-23
PCT/SG2017/050144 WO2017164815A1 (fr) 2016-03-23 2017-03-23 Biocapteur microfluidique de spectroscopie raman exaltée de surface (sers) pour détecter des analytes uniques et/ou multiples

Publications (1)

Publication Number Publication Date
SG11201807124PA true SG11201807124PA (en) 2018-09-27

Family

ID=59900618

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201807124PA SG11201807124PA (en) 2016-03-23 2017-03-23 Surface enhanced raman spectroscopy (sers) microfluidics biosensor for detecting single and/or multiple analytes

Country Status (4)

Country Link
US (1) US11237159B2 (fr)
EP (1) EP3433605B1 (fr)
SG (1) SG11201807124PA (fr)
WO (1) WO2017164815A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201913188UA (en) * 2016-02-22 2020-02-27 Agency Science Tech & Res Method for detecting an analyte using surface enhanced raman spectroscopy
BR112020024296A2 (pt) 2018-08-27 2021-03-09 Regeneron Pharmaceuticals, Inc. Métodos para produção de um intermediário de purificação de proteína concentrado, para monitoramento e controle dos atributos de qualidade críticos em um intermediário de purificação de proteína e para monitorar e controlar os níveis de excipientes no fluido de cultura de células colhido e/ou intermediário de purificação de proteína, e, intermediário de purificação de proteína
CN109187483B (zh) * 2018-09-10 2021-04-06 广西师范大学 一种用碳点催化h2o2-tmb反应产物sers测定so32-的方法
CN109459349B (zh) * 2018-12-13 2020-12-15 中国科学院烟台海岸带研究所 一种人工湿地短期沉积速率的测定方法
CN110292959B (zh) * 2019-06-21 2022-05-13 中国人民解放军军事科学院军事医学研究院 一种微流控芯片及其制备方法与应用
CA3151843A1 (fr) * 2019-08-22 2021-02-25 Cape Breton University Procedes de modification d'un echantillon liquide contenant un analyte de facon a augmenter l'intensite du signal sers de l'analyte, ainsi qu'une sonde pour la detection a distanc e d'un analyte a l'aide de sers
CN114034681B (zh) * 2021-10-27 2023-10-31 中山大学 一种玉米赤霉烯酮的表面增强拉曼光谱分析检测方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7267948B2 (en) * 1997-11-26 2007-09-11 Ut-Battelle, Llc SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips
US9689801B2 (en) 2009-12-22 2017-06-27 Agency For Science, Technology And Research SERS-based analyte detection
CN104823049A (zh) 2012-10-01 2015-08-05 普林斯顿大学理事会 具有增强的光学信号的微流体传感器
CN104422769A (zh) 2013-09-05 2015-03-18 天津市医药科学研究所 一种肿瘤标志物的检测方法
WO2016036410A1 (fr) 2014-09-05 2016-03-10 California Institute Of Technology Capteurs à effet raman exalté de surface multiplexés pour détection précoce de maladies et surveillance bactérienne in situ

Also Published As

Publication number Publication date
WO2017164815A1 (fr) 2017-09-28
EP3433605A1 (fr) 2019-01-30
US20200292538A1 (en) 2020-09-17
EP3433605B1 (fr) 2021-02-24
EP3433605A4 (fr) 2019-11-06
US11237159B2 (en) 2022-02-01

Similar Documents

Publication Publication Date Title
SG11201807124PA (en) Surface enhanced raman spectroscopy (sers) microfluidics biosensor for detecting single and/or multiple analytes
SG11201809913PA (en) Methods for detecting target nucleic acids in a sample
SG11201908509TA (en) Biosensors for biological or chemical analysis and methods of manufacturing the same
SG11201407668XA (en) Method and device for detecting an analyte in a body fluid
SG11201809349SA (en) System and method for in-line monitoring of airborne contamination and process health
SG11201408385TA (en) Methods of detecting diseases or conditions
SG11201900269XA (en) Channel sensing for independent links
SG11201407901PA (en) Single-particle analysis of particle populations
SG11201907762RA (en) Methods for multiplex detection of molecules
SG11201807444PA (en) Transposase-mediated imaging of the accessible genome
SG11201811324VA (en) Flowcell cartridge with floating seal bracket
SG11201811343SA (en) System and methods for detecting online fraud
SG11201807307VA (en) System and method for aerial system discrimination and action
SG11201805176RA (en) A method and an apparatus for monitoring and controlling deposit formation
SG11201407891QA (en) Interest profile of a user of a mobile application
SG11201803667RA (en) Systems and methods for region-adaptive defect detection
SG11201408002TA (en) Multi-parameter diabetes risk evaluations
SG11201804144UA (en) High-throughput imaging-based methods for predicting cell-type-specific toxicity of xenobiotics with diverse chemical structures
SG11201804866WA (en) Integrated system for quantitative real-time monitoring of hydrogen-induced cracking in simulated sour environment
SG11201406767VA (en) Microfilter and apparatus for separating a biological entity from a sample volume
SG11201903627VA (en) Immunoassay system capable of suggesting assays based on input data
SG11201811104TA (en) Screening kit and method
SG11201906413XA (en) Exposure apparatus
SG11201407509VA (en) Method of generating and characterizing a seismic signal in a drill bit
SG11201811467SA (en) A toxicant monitoring system