SG11201803767YA - A microneedle and a chip - Google Patents

A microneedle and a chip

Info

Publication number
SG11201803767YA
SG11201803767YA SG11201803767YA SG11201803767YA SG11201803767YA SG 11201803767Y A SG11201803767Y A SG 11201803767YA SG 11201803767Y A SG11201803767Y A SG 11201803767YA SG 11201803767Y A SG11201803767Y A SG 11201803767YA SG 11201803767Y A SG11201803767Y A SG 11201803767YA
Authority
SG
Singapore
Prior art keywords
international
substrate
microneedle
capillary bore
proximal end
Prior art date
Application number
SG11201803767YA
Inventor
Markus Renlund
Pelle Rangsten
Original Assignee
Ascilion Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascilion Ab filed Critical Ascilion Ab
Publication of SG11201803767YA publication Critical patent/SG11201803767YA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0406—Constructional details of apparatus specially shaped apparatus housings
    • A61B2560/0412—Low-profile patch shaped housings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150068—Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau .... .51d ) (43) International Publication Date .... ....C...) 8 June 2017 (08.06.2017) W I P01 P CT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111111111111111111111111 2017/095321 Publication Number Al (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61M 37/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, PCT/SE2016/051211 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (22) International Filing Date: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 2 December 2016 (02.12.2016) OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (25) Filing Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (26) Publication Language: English ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 1530184-9 4 December 2015 (04.12.2015) SE kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: ASCILION AB [SE/SE]; Electrum 208, Isaf- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, jordsgatan 22, 16440 Kista (SE). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: RENLUND, Markus; Spjutvagen 38, 184 60 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Akersberga (SE). RANGSTEN, Pelle; Vretalundsvagen 8, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 743 40 Storvreta (SE). GW, KM, ML, MR, NE, SN, TD, TG). (74) Agent: ZACCO SWEDEN AB; Box 5581, Valhallavagen Published: 117N, 114 85 Stockholm (SE). — with international search report (Art 21(3)) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (54) Title: A MICRONEEDLE AND A CHIP 115 1 12 ;17 ''' ' 107 101 '' „.... • .:.• v, k yk .k. ;•••k , ... ,,,,,, \" ................... 1 \"%.\" ' ; ,_____. \/ I'l / 1 \ \ \ . .4t 102 .\\....:\ - • 1-1 ei M in in FIG. 1 o IN (57) : A microneedle and a chip are disclosed for extraction of fluids. The microneedle (101) provided on a substrate (102), 1-1 c:::, comprises an elongated body (503) extending from a distal end (504) with a bevel (505) to a proximal end (506) on the substrate el along a longitudinal axis; the elongated body comprises a capillary bore (507) extending in a longitudinal direction thereof and 0 defines a fluid path (508); the proximal end is integrally connected with the substrate and the capillary bore is in fluid communica- tion with a fluid channel (309) of the substrate. The cross-sectional area of the capillary bore in the distal end is larger than the cross- sectional area of the capillary bore in the proximal end.
SG11201803767YA 2015-12-04 2016-12-02 A microneedle and a chip SG11201803767YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1530184 2015-12-04
PCT/SE2016/051211 WO2017095321A1 (en) 2015-12-04 2016-12-02 A microneedle and a chip

Publications (1)

Publication Number Publication Date
SG11201803767YA true SG11201803767YA (en) 2018-06-28

Family

ID=58797598

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201803767YA SG11201803767YA (en) 2015-12-04 2016-12-02 A microneedle and a chip

Country Status (13)

Country Link
US (2) US11160963B2 (en)
EP (1) EP3285851B1 (en)
JP (2) JP6810151B2 (en)
KR (1) KR101959184B1 (en)
CN (1) CN108430564B (en)
AU (1) AU2016361874B2 (en)
CA (1) CA3007291C (en)
ES (1) ES2865489T3 (en)
HK (1) HK1248629A1 (en)
IL (1) IL259195B (en)
MY (1) MY197273A (en)
SG (1) SG11201803767YA (en)
WO (1) WO2017095321A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI778065B (en) 2017-07-25 2022-09-21 瑞典商艾瑟莉恩公司 A suction applying device and an apparatus for sampling a bodily fluid
SE1751461A1 (en) 2017-11-28 2019-05-29 Ascilion Ab Method of detecting an exogenous agent in interstitial fluid
KR20220047980A (en) * 2019-07-12 2022-04-19 아스실리온 에이비 Integrated sensor assembly unit
EP3772331A1 (en) * 2019-08-08 2021-02-10 PKvitality Body monitoring system comprising a microneedle
USD910841S1 (en) * 2020-05-14 2021-02-16 Gravity Holdings, LLC Circular hypodermic needle array with evenly spaced needles
USD910842S1 (en) * 2020-05-14 2021-02-16 Gravity Holdings, LLC Square shaped hypodermic needle array with evenly spaced needles
USD910844S1 (en) * 2020-05-14 2021-02-16 Gravity Holdings, LLC Rectangular hypodermic needle array with evenly spaced needles
USD910843S1 (en) * 2020-05-14 2021-02-16 Gravity Holdings, LLC Triangular hypodermic needle array with evenly spaced needles
USD921194S1 (en) * 2020-05-14 2021-06-01 Gravity Holdings, LLC Triangular hypodermic needle array
USD921193S1 (en) * 2020-05-14 2021-06-01 Gravity Holdings, LLC Circular hypodermic needle array
USD920505S1 (en) * 2020-05-14 2021-05-25 Gravity Holdings, LLC Square shaped hypodermic needle array
USD920506S1 (en) * 2020-05-14 2021-05-25 Gravity Holdings, LLC Rectangular hypodermic needle array
KR102297883B1 (en) * 2021-02-17 2021-09-03 주식회사 지엘캄퍼니 Micro Needle Assembly
AU2022306407A1 (en) 2021-07-07 2024-02-22 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
US11717660B2 (en) * 2021-07-29 2023-08-08 Nanopass Technologies Ltd. Silicon microneedle structure and production method
CN114546000A (en) * 2022-01-10 2022-05-27 武汉衷华脑机融合科技发展有限公司 Temperature control system for neural interface
KR20230122860A (en) 2022-02-15 2023-08-22 (주) 세진프리시젼 Squeeze coating apparatus for manufacturing micro-needle and micro-needle manufacturing method using the squeeze coating apparatus for manufacturing micro-needle
KR20230137550A (en) 2022-03-22 2023-10-05 (주) 세진프리시젼 Multiple-stage mold apparatus for manufacturing plural floor micro-needle

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
US6603987B2 (en) * 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
EP2111885B1 (en) * 2002-02-04 2011-09-21 Becton, Dickinson and Company Device and method for delivering or withdrawing a substance through the skin
CN100591386C (en) 2002-06-25 2010-02-24 权圣润 Rapidly dissolving micro-perforator for drug delivery and other applications
KR100563330B1 (en) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Method for manufacturing of polymer micro needle array with liga process
WO2005020817A1 (en) * 2003-09-01 2005-03-10 Inverness Medical Switzerland Gmbh Sampling device with capillary action
EP1713533A4 (en) 2003-11-21 2008-01-23 Univ California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
WO2007040938A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Functionalized microneedles transdermal drug delivery systems, devices, and methods
TWI300055B (en) * 2006-05-26 2008-08-21 Nat Univ Tsing Hua Method of manufacturing hollow micro-needle structures
US20090318833A1 (en) 2006-09-18 2009-12-24 Agency For Science Technology And Research Needle Structures and Methods for Fabricating Needle Structures
US20080091226A1 (en) * 2006-10-17 2008-04-17 Nanopass Technologies Ltd. Microneedle device
KR20090059971A (en) 2007-12-07 2009-06-11 인싸이토 주식회사 Hollow microneedle
CN102405018B (en) * 2009-03-02 2014-11-19 第七感生物系统有限公司 Techniques and devices associated with blood sampling
JP2011012050A (en) * 2009-06-03 2011-01-20 Bioserentack Co Ltd Microneedle array using porous substrate and method for producing the same
DE102009046581A1 (en) * 2009-11-10 2011-05-12 Robert Bosch Gmbh Manufacturing method for a porous microneedle array and corresponding porous microneedle array and corresponding substrate composite
JP6012198B2 (en) * 2012-02-22 2016-10-25 日精株式会社 Capillary blood collection tool
US20130296824A1 (en) * 2012-05-03 2013-11-07 Uc Biodevices Corporation Microneedle based transdermal drug delivery device and method
GB201213073D0 (en) * 2012-07-23 2012-09-05 Renephra Ltd Microneelde-based devices and methods for the removal of fluid from a body
EP2929333B1 (en) * 2012-12-07 2018-07-04 Ascilion AB A microfabricated sensor and a method of sensing the level of a component in bodily fluid
WO2015009524A1 (en) * 2013-07-16 2015-01-22 3M Innovative Properties Company Hollow microneedle with beveled tip
US20150174386A1 (en) * 2013-12-19 2015-06-25 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles

Also Published As

Publication number Publication date
KR20180085029A (en) 2018-07-25
EP3285851A4 (en) 2018-09-12
IL259195A (en) 2018-07-31
IL259195B (en) 2021-12-01
JP2019500980A (en) 2019-01-17
CA3007291C (en) 2019-10-22
CA3007291A1 (en) 2017-06-08
WO2017095321A1 (en) 2017-06-08
ES2865489T3 (en) 2021-10-15
AU2016361874B2 (en) 2019-01-03
KR101959184B1 (en) 2019-03-15
CN108430564B (en) 2022-01-11
EP3285851B1 (en) 2021-01-20
US20180161563A1 (en) 2018-06-14
US20220023606A1 (en) 2022-01-27
JP2021000495A (en) 2021-01-07
HK1248629A1 (en) 2018-10-19
JP6873303B2 (en) 2021-05-19
AU2016361874A1 (en) 2018-06-07
US11160963B2 (en) 2021-11-02
JP6810151B2 (en) 2021-01-06
EP3285851A1 (en) 2018-02-28
CN108430564A (en) 2018-08-21
MY197273A (en) 2023-06-08

Similar Documents

Publication Publication Date Title
SG11201803767YA (en) A microneedle and a chip
SG11201900809TA (en) Combination steerable catheter and systems
SG11201909505QA (en) Blood pump with reinforced catheter
SG11201808539WA (en) Mouth piece for cooling of oral tissue of a patient during chemotherapy treatment
SG11201805570WA (en) Systems and methods for long term transdermal administration
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201803905RA (en) A hair styling appliance
SG11201805368YA (en) Anthelmintic depsipeptide compounds
SG11201805950UA (en) Self-assembled nanostructures and separation membranes comprising aquaporin water channels and methods of making and using them
SG11201407873RA (en) Endoscopic sympathectomy systems and methods
SG11201809341PA (en) Mobile robot
SG11201807191YA (en) Apparatus for subretinal administration of therapeutic agent via a curved needle
SG11201805072PA (en) Nicotine powder delivery system
SG11201807913XA (en) Stabilized soluble pre-fusion rsv f proteins
SG11201804821PA (en) A beverage capsule
SG11201407580YA (en) Composition comprising two antibodies engineered to have reduced and increased effector function
SG11201407200TA (en) Liquid formulation
SG11201407340YA (en) Treatment of myelosuppression
SG11201809908TA (en) Stabilized glycopeptide antibiotic formulations
SG11201406787TA (en) Rnai-based therapies for cardiomyopathies, muscular dystrophies and laminopathies
SG11201408337PA (en) Methods of decellularizing bone
SG11201407740UA (en) Flush enhancing male luer tip design for syringes and any luer connector
SG11201901351UA (en) A patient interface, system and method
SG11201407635XA (en) Generation of functional and durable endothelial cells from human amniotic fluid-derived cells
SG11201909003YA (en) Integrated vascular access device and anchor pad