SE1751461A1 - Method of detecting an exogenous agent in interstitial fluid - Google Patents

Method of detecting an exogenous agent in interstitial fluid

Info

Publication number
SE1751461A1
SE1751461A1 SE1751461A SE1751461A SE1751461A1 SE 1751461 A1 SE1751461 A1 SE 1751461A1 SE 1751461 A SE1751461 A SE 1751461A SE 1751461 A SE1751461 A SE 1751461A SE 1751461 A1 SE1751461 A1 SE 1751461A1
Authority
SE
Sweden
Prior art keywords
agent
interstitial fluid
skin
detecting
exogenous agent
Prior art date
Application number
SE1751461A
Inventor
Markus Renlund
Mikael Hillmering
Original Assignee
Ascilion Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascilion Ab filed Critical Ascilion Ab
Priority to SE1751461A priority Critical patent/SE1751461A1/en
Priority to EP18814803.5A priority patent/EP3758605A1/en
Priority to PCT/EP2018/082552 priority patent/WO2019105890A1/en
Publication of SE1751461A1 publication Critical patent/SE1751461A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid

Abstract

The present disclosure relates to a method of analyzing local percutaneous absorption of an agent, comprising steps of applying the agent to the skin of a subject, extracting interstitial fluid from the skin using at least one hollow microneedle, and determining a presence of the agent in the extracted interstitial fluid, wherein the presence of the agent in the extracted interstitial fluid indicates local percutaneous absorption of an agent. Further, a method for determining whether a person has been exposed to an agent capable of penetrating the skin, comprising steps of extracting interstitial fluid from the skin of a subject with at least one hollow microneedle, and determining a presence of the agent in the interstitial fluid is disclosed.
SE1751461A 2017-11-28 2017-11-28 Method of detecting an exogenous agent in interstitial fluid SE1751461A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE1751461A SE1751461A1 (en) 2017-11-28 2017-11-28 Method of detecting an exogenous agent in interstitial fluid
EP18814803.5A EP3758605A1 (en) 2017-11-28 2018-11-26 Method of analyzing percutaneous absorption of an agent
PCT/EP2018/082552 WO2019105890A1 (en) 2017-11-28 2018-11-26 Method of analyzing percutaneous absorption of an agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE1751461A SE1751461A1 (en) 2017-11-28 2017-11-28 Method of detecting an exogenous agent in interstitial fluid

Publications (1)

Publication Number Publication Date
SE1751461A1 true SE1751461A1 (en) 2019-05-29

Family

ID=64606947

Family Applications (1)

Application Number Title Priority Date Filing Date
SE1751461A SE1751461A1 (en) 2017-11-28 2017-11-28 Method of detecting an exogenous agent in interstitial fluid

Country Status (3)

Country Link
EP (1) EP3758605A1 (en)
SE (1) SE1751461A1 (en)
WO (1) WO2019105890A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US20040171980A1 (en) * 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
CA2605754A1 (en) * 2005-04-29 2006-11-09 Johnson & Johnson Consumer Companies, Inc. Topical composition fluorescence detection
US20110112121A1 (en) * 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US8147466B2 (en) * 2008-01-25 2012-04-03 The Procter And Gamble Company Method of determining a skin agent transferred to skin
US20120253143A1 (en) * 2011-04-04 2012-10-04 Raphael Warren Method of measuring a skin agent transferred to skin
WO2014088493A1 (en) * 2012-12-07 2014-06-12 Ascilion Ab A microfabricated sensor and a method of sensing the level of a component in bodily fluid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011116388A1 (en) 2010-03-19 2011-09-22 Nanostar Health Corporation Body fluid sampling/fluid delivery device
WO2014160804A2 (en) * 2013-03-26 2014-10-02 The Trustees Of Columbia University In The City Of New York Fluid extraction and drug delivery system and methods using microneedles
US20160166185A1 (en) 2013-08-22 2016-06-16 The Regents Of The University Of California Blood analyte collection device and methods of use thereof
WO2015187066A1 (en) 2014-06-07 2015-12-10 Ascilion Ab A microfabricated sensor and a method of detecting a component in bodily fluid
US20160296149A1 (en) 2015-04-08 2016-10-13 Sandia Corporation In Vivo Extraction of Interstitial Fluid Using Hollow Microneedles
CA3007291C (en) 2015-12-04 2019-10-22 Ascilion Ab A microneedle and a chip

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190315B1 (en) * 1998-01-08 2001-02-20 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US20040171980A1 (en) * 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
CA2605754A1 (en) * 2005-04-29 2006-11-09 Johnson & Johnson Consumer Companies, Inc. Topical composition fluorescence detection
US8147466B2 (en) * 2008-01-25 2012-04-03 The Procter And Gamble Company Method of determining a skin agent transferred to skin
US20110112121A1 (en) * 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
US20120253143A1 (en) * 2011-04-04 2012-10-04 Raphael Warren Method of measuring a skin agent transferred to skin
WO2014088493A1 (en) * 2012-12-07 2014-06-12 Ascilion Ab A microfabricated sensor and a method of sensing the level of a component in bodily fluid

Also Published As

Publication number Publication date
WO2019105890A1 (en) 2019-06-06
EP3758605A1 (en) 2021-01-06

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