KR20230137550A - Multiple-stage mold apparatus for manufacturing plural floor micro-needle - Google Patents

Abstract

As the disclosed multi-stage mold device for manufacturing a multi-layer microneedle includes a first-stage mold and a second-stage mold, a needle primary material is molded into the first-stage needle forming hole formed in the first-stage mold, and the second stage mold is formed in the second-stage mold. However, by forming the needle secondary material in a form connected to the needle primary material in the needle forming hole, there is an advantage in that a multi-layer microneedle in which multiple types of materials are stacked in multiple layers can be manufactured.

Description

Multiple-stage mold apparatus for manufacturing plural floor micro-needle}

The present invention relates to a multi-stage mold device for manufacturing multi-layer microneedles.

A micro-needle is a microneedle that passes through the stratum corneum, the outermost layer of the skin, and delivers active ingredients such as drugs to the epidermis and dermis. The needle has a thickness of hundreds of micrometers (μm, 1μm=1/ 1,000,000 m), which is only about 1/3 the thickness of a human hair, and is one of the means of transdermal drug delivery system (TDDS; transdermal drug delivery system) that absorbs drugs into the body through the skin rather than oral or injectable administration.

An example of such a microneedle is that of the patent document presented below.

However, according to conventional microneedles, they are generally manufactured only from a single material, and there is a problem in that it is not easy to manufacture them in a form in which multiple types of materials are stacked.

Registration Patent No. 10-1959184, Registration Date: 2019.03.11., Title of Invention: Microneedle and Chip

An object of the present invention is to provide a multi-layer molding device for manufacturing a multi-layer microneedle that allows the manufacture of a multi-layer microneedle in which multiple types of materials are stacked in multiple layers.

A multi-stage mold device for manufacturing a multi-layer microneedle according to an aspect of the present invention is for manufacturing a multi-layer microneedle composed of multiple layers including a needle primary material and a needle secondary material connected to the needle primary material. ,

A first-stage mold with a first-stage needle forming hole for forming the needle primary material; and a two-stage mold that can be detachably overlapped on the first-stage mold and is in communication with the first-stage needle forming hole and has a second-stage needle forming hole for forming the needle secondary material.

With the needle primary material molded inside the first-stage needle forming hole, the second-stage mold is overlapped on the first-stage mold so that the first-stage needle forming hole and the second-stage needle forming hole are in communication, and In a state in which the second-stage mold is overlapped on the first-stage mold, the needle secondary material is molded inside the second-stage needle forming hole in a form connected to the needle primary material.

According to the multi-stage mold device for manufacturing a multi-layer micro needle according to an aspect of the present invention, the multi-stage mold device for manufacturing a multi-layer micro needle includes a first stage mold and a second stage mold, so that the first stage needle formed in the first stage mold is formed. A needle primary material is formed in the hole, and a needle secondary material is formed in a form connected to the needle primary material in the two-stage needle forming hole formed in the two-stage mold, so that multiple types of materials are stacked in multiple layers. This has the effect of allowing multi-layer microneedles to be manufactured.

Figure 1 is a cross-sectional view showing a first-stage mold and a second-stage mold constituting a multi-stage mold device for manufacturing a multi-layer microneedle according to an embodiment of the present invention overlapped.
Figure 2 is a cross-sectional view showing the first-stage mold and the second-stage mold constituting the multi-stage mold device for manufacturing a multi-layer microneedle according to an embodiment of the present invention separated.
Figure 3 is a diagram showing a first-stage mold and a squeeze member constituting a multi-stage mold device for manufacturing multi-layer microneedles according to an embodiment of the present invention.
Figure 4 is a cross-sectional view showing the needle primary material being molded in a single-stage mold constituting a multi-stage mold device for manufacturing a multi-layer microneedle according to an embodiment of the present invention.
Figure 5 is a cross-sectional view showing a second-stage mold overlapped on the first-stage mold shown in Figure 4.
Figure 6 is a cross-sectional view showing the needle secondary material molded on the needle primary material shown in Figure 5.
Figure 7 is an enlarged cross-sectional view of a portion of a squeeze member constituting a multi-stage mold device for manufacturing a multi-layer microneedle according to another embodiment of the present invention.
Figure 8 is an enlarged cross-sectional view of the portion to which the backflow prevention member shown in Figure 7 is applied.

Hereinafter, a multi-stage mold device for manufacturing a multi-layer microneedle according to embodiments of the present invention will be described with reference to the drawings.

Figure 1 is a cross-sectional view showing a first-stage mold and a second-stage mold constituting a multi-stage mold device for manufacturing a multi-layer microneedle according to an embodiment of the present invention, and Figure 2 is a multi-layer mold according to an embodiment of the present invention. It is a cross-sectional view showing the first-stage mold and the second-stage mold constituting the multi-stage mold device for manufacturing microneedles separated, and Figure 3 shows the first-stage mold constituting the multi-stage mold apparatus for manufacturing multi-layer microneedles according to an embodiment of the present invention. and a squeeze member, FIG. 4 is a cross-sectional view showing the needle primary material being molded in a single-stage mold constituting a multi-stage mold device for manufacturing multi-layer microneedles according to an embodiment of the present invention, and FIG. 5 is a It is a cross-sectional view showing a second-stage mold being overlapped on the first-stage mold shown in FIG. 4, and FIG. 6 is a cross-sectional view showing a needle secondary material being molded on the needle primary material shown in FIG. 5.

Referring to FIGS. 1 to 6 together, the multi-stage mold device 100 for manufacturing a multi-layer microneedle according to this embodiment includes a needle primary material 170 and a needle secondary material connected to the needle primary material 170. It is for manufacturing a multi-layer microneedle composed of multiple layers including (175), and includes a first-stage mold (150) and a second-stage mold (155).

Additionally, the multi-stage mold device 100 for manufacturing a multi-layer microneedle may include a squeeze member 110.

The needle primary material 170 constitutes the uppermost part of the multi-layer microneedle, and the needle secondary material 175 is arranged to be connected to the lower part of the needle primary material 170, and the needle primary material 170 The multi-layered microneedle, which is formed by stacking 170 and the needle secondary material 175, is formed as a whole in a tapered shape that becomes sharper toward the top.

The needle primary material 170 and the needle secondary material 175 are made of different types of materials, so that the multi-layer microneedle is formed by stacking multiple types of materials in multiple layers.

Here, the multi-layer microneedle is presented as being composed of two stages of the needle primary material 170 and the needle secondary material 175, but this is an example for convenience of explanation, and the needle primary material In addition to 170 and the needle secondary material 175, additional layers such as needle tertiary material may be added to the lower part of the needle secondary material 175, so that the multi-layer microneedle may be composed of three or more stages, To this end, in addition to the first-stage mold 150 and the second-stage mold 155, a third-stage mold, etc. may be additionally stacked on the second-stage mold 155.

The first-stage mold 150 is formed with a first-stage needle forming hole 151 for molding the needle primary material 170, and may be formed in the shape of a large plate with a predetermined area.

The first-stage needle forming hole 151 is formed in a shape that is recessed to a predetermined depth from the top of the first-stage mold 150 and is formed in a tapered shape that gradually becomes narrower toward the bottom, so that the first-stage needle forming hole 151 The needle primary material 170 formed by 151 has a sharp shape.

The second-stage mold 155 can be detachably overlapped on the first-stage mold 150, and communicates with the first-stage needle forming hole 151, forming a second stage for forming the needle secondary material 175. However, since the needle forming hole 156 is formed, it can be formed in the shape of a large plate with a predetermined area.

The second-stage needle forming hole 156 is formed to penetrate the second-stage mold 155 and gradually widens from the lower part connected to the first-stage needle forming hole 151 to the upper part. do.

The first-stage needle forming hole 151 and the second-stage needle forming hole 156 may be formed in the first-stage mold 150 and the second-stage mold 155, respectively, to form a plurality of pairs.

In a state in which the first raw material constituting the needle primary material 170 is filled inside the first-stage needle forming hole 151 and the needle primary material 170 is formed, the first-stage needle forming hole 151 ) The second-stage mold 155 is overlapped on the first-stage mold 150 so that the second-stage needle forming hole 156 is in communication, and the second stage mold 150 is placed on the first-stage mold 150 as described above. In the state where the mold 155 is overlapped, the second stage needle forming hole 156 is filled with the secondary raw material constituting the needle secondary material 175, thereby connecting to the needle primary material 170. The needle secondary material 175 is formed inside the two-stage needle forming hole 156.

The needle primary material 170 can be formed by filling the first-stage needle forming hole 151 with the primary raw material and drying it for a predetermined time, and the second-stage needle forming hole 156 The needle primary material 170 is filled with the secondary raw material inside the needle primary material 170 and dried for a predetermined period of time, thereby forming the needle primary material 170 in a form connected to the needle primary material 170. It can be molded.

The squeeze member 110 protrudes out of the first-stage needle forming hole 151 among the primary raw materials filled in the first-stage needle forming hole 151 for forming the needle primary material 170. removing the part.

The squeeze member 110 is formed to have a length that can contact the upper surface of the first-stage mold 150 as a whole, and is in contact with the upper surface of the first-stage mold 150 as a whole and is positioned on one side of the first-stage mold 150. While moving to the other side, the portion protruding outside of the first-stage needle forming holes 151 among the primary raw materials filled in the plurality of first-stage needle forming holes 151 can be removed by pushing out.

Meanwhile, the multi-stage mold device 100 for manufacturing a multi-layer microneedle includes a lifting member 120 capable of lifting the squeeze member 110 toward the first stage mold 150, and a lifting member 120 that moves the squeeze member 110 toward the first stage mold 150. However, it includes a moving member 125 that can be moved along the upper surface of the mold 150.

The lifting member 120 is a hydraulic cylinder, etc., and the squeezing member 110 is connected to the piston of the lifting member 120, so that the squeezing member 110 is lowered according to the operation of the lifting member 120. The first-stage mold 150 may be in contact with the first-stage mold 150 or the squeeze member 110 may be raised to be spaced apart from the first-stage mold 150 .

The moving member 125 can move the lifting member 120 to which the squeezing member 110 is connected from one side of the first stage mold 150 to the other side. An example of the moving member 125 may be a hydraulic or pneumatic cylinder whose piston is connected to the distal end of the lifting member 120.

Hereinafter, the operation of the multi-stage mold device 100 for manufacturing a multi-layer microneedle according to this embodiment will be described with reference to the drawings.

First, in a state where the first stage needle forming hole 151 of the first stage mold 150 is filled with the first raw material, the squeeze member 110 is lowered by the lifting member 120 to move to the first stage. It is in contact with the mold 150 and is moved from one side of the first-stage mold 150 to the other side by the moving member 125, so that any of the primary raw material is randomly moved to the outside of the first-stage needle forming hole 151. By removing the protruding portion and drying in this state for a predetermined time, the needle primary material 170 can be formed inside the first-stage needle forming hole 151, as shown in FIG. 4.

Then, as shown in FIG. 5, the second-stage mold 155 is placed on the first-stage mold 150 so that the first-stage needle forming hole 151 and the second-stage needle forming hole 156 are aligned. They overlap.

Then, as shown in FIG. 6, the secondary raw material is filled in the two-stage needle forming hole 156 and dried in this state for a predetermined time, thereby forming the inside of the two-stage needle forming hole 156. By forming the needle secondary material 175 connected to the needle primary material 170, the multi-layer microneedle is manufactured.

As described above, as the multi-stage mold device 100 for manufacturing a multi-layer microneedle includes the first-stage mold 150 and the second-stage mold 155, the first-stage needle formed in the first-stage mold 150 The needle primary material 170 is molded in the forming hole 151 and connected to the needle primary material 170 in the two-stage needle forming hole 156 formed in the two-stage mold 155. By molding the needle secondary material 175, the multi-layer microneedle in which multiple types of materials are stacked in multiple layers can be manufactured.

Hereinafter, a multi-stage mold device for manufacturing a multi-layer microneedle according to another embodiment of the present invention will be described with reference to the drawings. In carrying out this description, descriptions that overlap with those already described in the above-described embodiment of the present invention will be replaced and omitted here.

FIG. 7 is an enlarged cross-sectional view of a portion of a squeeze member constituting a multi-stage mold device for manufacturing a multi-layer microneedle according to another embodiment of the present invention, and FIG. 8 is an enlarged cross-sectional view of a portion to which the backflow prevention member shown in FIG. 7 is applied. am.

Referring to FIGS. 7 and 8 together, in this embodiment, the distal end of the squeeze member 210 includes a removal body inlet hole 230, a connection hole 231, a drop hole 232, and an external outlet pipe ( 215), a backflow prevention wall 235, and a backflow prevention member 240.

The removal body inlet hole 230 is formed in an open form from the end of the tip of the squeeze member 210 to a predetermined height, and is formed in a form exposed toward the moving direction of the squeeze member 210, so as to form a first-stage needle. Among the materials filled in the forming hole, the removal material, which is the part that protrudes to the outside of the first-stage needle forming hole and is removed by the squeeze member 210, is introduced.

The connection hole 231 is formed inside the squeeze member 210 to communicate with the removal body inlet hole 230, and is formed at a relatively higher position compared to the removal body inlet hole 230. It is formed in a relatively narrow shape compared to the removal material inlet hole 230, so that the removal material introduced through the removal material inlet hole 230 flows.

When the squeeze member 210 moves and the removal material continues to flow into the removal material inlet hole 230, the removal material that has already flowed into the removal material inlet hole 230 flows into the connection hole 231. It gets pushed up.

The drop hole 232 is formed in the squeeze member 210 to communicate with the connection hole 231, and is open on a side of the squeeze member 210 other than the direction of movement of the squeeze member 210. is formed by

The bottom of the drop hole 232 is formed at a relatively low position compared to the connection hole 231, so that the removal material flowing along the connection hole 231 falls toward the bottom of the drop hole 232.

The external discharge pipe 215 is connected to the dropping hole 232 and extends to the outside, thereby allowing the removal material that has fallen into the dropping hole 232 to flow and be discharged to the outside.

The backflow prevention wall 235 is formed inside the squeeze member 210 in the form of a wall blocking between the removal body inlet hole 230 and the drop hole 232, and the connection hole 231 of the removal body. ) to prevent backflow.

The upper part of the backflow prevention wall 235 forms the bottom of the connection hole 231.

The removal body formed by the squeeze member 210 flows in through the removal body inlet hole 230, flows through the connection hole 231, and then falls into the drop hole 232. It can leak out to the outside through the external outflow pipe 215.

The backflow prevention member 240 has a shape that protrudes from the ceiling of the connection hole 231 and extends to the upper part of the backflow prevention wall 235 toward the drop hole 232, and is made of rubber, etc. It is made of an elastic material, and when the removal body flows from the connection hole 231 side to the falling hole 232, it opens while being elastically deformed, and the removal body flows into the falling hole 232 from the connection hole 231 side. Except when it flows, the space between the connection hole 231 and the falling hole 232 is always closed to prevent the removal material from flowing back into the connecting hole 231 from the falling hole 232.

In detail, the backflow prevention member 240 includes a backflow prevention body 241, a backflow prevention elastic hole forming body 242, and an end contact body 243.

The backflow prevention body 241 blocks between the connection hole 231 and the dropping hole 232, and the upper part of the backflow prevention body 241 protrudes from the ceiling of the connection hole 231. It is fixed to the ceiling of the connection hole 231, and the lower part of the backflow prevention body 241 is in contact with the upper part of the backflow prevention wall 235 toward the dropping hole 232.

The backflow prevention elastic hole forming body 242 extends from the end of the backflow prevention body 241, is formed in the shape of a hemisphere with a predetermined curvature, and has an empty hemisphere inside, forming an upper part of the backflow prevention wall 235. A backflow prevention elastic hole 236 of a predetermined size is formed on the surface of the drop hole 232.

The end adhesive body 243 extends from the end of the backflow prevention elastic hole forming body 242 and can be in close contact with the upper surface of the backflow prevention wall 235 toward the dropping hole 232.

When the removal body flows from the connection hole 231 to the falling hole 232, the backflow prevention body 241 is pushed by the removal body, so that the distal end of the backflow prevention body 241, the backflow prevention body 241 Both the prevention elastic hole forming body 242 and the end adhesion body 243 are spaced apart from the upper surface of the backflow prevention wall 235 toward the falling hole 232, so that the removal body is connected to the backflow prevention wall 235. It can flow into the dropping hole 232 through a gap formed between the upper surface of the falling hole 232 and the backflow prevention member 240.

At this time, the backflow prevention body 241, the backflow prevention elastic hole forming body 242, and the end contact body 243 are elastically deformed and restore force is accumulated.

When the introduction of the removal body into the dropping hole 232 is completed, the backflow prevention body 241, the backflow prevention elastic hole forming body 242, and the end contact body 243 are formed into a circle by their restoring force. is restored, and as a result, the distal end of the backflow prevention body 241, the backflow prevention elastic hole forming body 242, and the end close contact body 243 are located in the drop hole 232 in the upper part of the backflow prevention wall 235. adheres closely to the surface.

In this state, when the removal material tries to flow back into the connection hole 231 from the falling hole 232 side, the backflow prevention elastic hole forming body 242 tries to flow backward from the falling hole 232 side. As it is pressed by the pressure of the sieve, some of the air inside the backflow prevention elastic hole 236 is between the upper surface of the backflow prevention wall 235 toward the drop hole 232 and the end contact body 243. It escapes through the gap, and as a result, the backflow prevention elastic hole forming body 242 tries to be restored to its original shape by the self-restoring force of the backflow prevention elastic hole forming body 242, and the backflow preventing elastic hole forming body 236 As the internal pressure becomes relatively low compared to the drop hole 232, the distal end of the backflow prevention body 241, the backflow prevention elastic hole forming body 242, and the end contact body 243 prevent the backflow. By being able to adhere more firmly to the upper surface of the prevention wall 235 toward the falling hole 232, the backflow of the removal body can be prevented more smoothly.

Although the present invention has been shown and described in relation to specific embodiments in the above, those skilled in the art can modify the present invention in various ways without departing from the spirit and scope of the present invention as set forth in the claims below. You will see that it can be changed. However, we would like to make it clear that all such modifications and modified structures are included within the scope of the present invention.

According to the multi-layer mold device for manufacturing multi-layer microneedles according to one aspect of the present invention, it is possible to manufacture multi-layer microneedles in which multiple types of materials are stacked in multiple layers, so it can be said to have high industrial applicability.

100: Multi-stage mold device for manufacturing multi-layer microneedles
110: Squeeze member
150: 1st stage mold
151: 1st stage needle forming hole
155: 2-stage mold
156: 2-stage needle forming hole
170: Needle primary material
175: Needle secondary material

Claims (3)

For manufacturing a multi-layer microneedle composed of multiple layers including a needle primary material and a needle secondary material connected to the needle primary material,
A first-stage mold with a first-stage needle forming hole for forming the needle primary material; and
A two-stage mold that can be detachably overlapped on the first-stage mold and is in communication with the first-stage needle forming hole and has a second-stage needle forming hole for forming the needle secondary material;
With the needle primary material molded inside the first-stage needle forming hole, the second-stage mold is overlapped on the first-stage mold so that the first-stage needle forming hole and the second-stage needle forming hole communicate,
For manufacturing a multi-layer microneedle, wherein the second-stage mold is overlapped on the first-stage mold, and the needle secondary material is molded inside the second-stage needle forming hole in a form connected to the needle primary material. Multi-stage mold device. According to claim 1,
The first-stage needle forming hole is formed in a tapered shape that gradually becomes narrower toward the bottom,
A multi-stage mold device for manufacturing a multi-layer microneedle, wherein the second-stage needle forming hole is formed in a shape that gradually widens from the lower part connected to the first-stage needle forming hole to the upper part. According to claim 1,
A multi-layer microneedle comprising a squeeze member that removes a portion of the primary raw material filled in the first-stage needle forming hole for forming the needle primary material that protrudes out of the first-stage needle forming hole. Multi-stage mold device for manufacturing.