SG11201800989RA - Antibody against glypican-3 and application thereof - Google Patents

Antibody against glypican-3 and application thereof

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Publication number
SG11201800989RA
SG11201800989RA SG11201800989RA SG11201800989RA SG11201800989RA SG 11201800989R A SG11201800989R A SG 11201800989RA SG 11201800989R A SG11201800989R A SG 11201800989RA SG 11201800989R A SG11201800989R A SG 11201800989RA SG 11201800989R A SG11201800989R A SG 11201800989RA
Authority
SG
Singapore
Prior art keywords
application
antibody against
against glypican
glypican
antibody
Prior art date
Application number
SG11201800989RA
Other languages
English (en)
Inventor
Huamao Wang
Bo Song
Original Assignee
Carsgen Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carsgen Therapeutics Ltd filed Critical Carsgen Therapeutics Ltd
Publication of SG11201800989RA publication Critical patent/SG11201800989RA/en

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Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016049459A1 (en) 2014-09-26 2016-03-31 Baylor College Of Medicine Glypican-3 specific chimeric antigen receptors for adoptive immunotherapy
CN109153719B (zh) * 2016-03-15 2022-12-30 中外制药株式会社 使用pd-1轴结合拮抗剂和抗gpc3抗体治疗癌症的方法
WO2018018958A1 (en) 2016-04-22 2018-02-01 Carsgen Therapeutics Co., Ltd. Compositions and methods of cellular immunotherapy
CN108456250B (zh) * 2017-02-17 2025-11-28 恺兴生命科技(上海)有限公司 靶向il-13ra2的抗体及其应用
CN110753555A (zh) 2017-04-19 2020-02-04 得克萨斯州大学系统董事会 表达工程化抗原受体的免疫细胞
CN108853144A (zh) * 2017-05-16 2018-11-23 科济生物医药(上海)有限公司 Toll样受体激动剂与免疫效应细胞的联用
CN108866003A (zh) * 2017-05-16 2018-11-23 科济生物医药(上海)有限公司 基因工程化的细胞及应用
CN107129536A (zh) * 2017-05-24 2017-09-05 广州市拜沃思生物科技有限公司 一种双特异性抗体及其制备方法和应用
CN107384949B (zh) * 2017-06-27 2019-01-15 闾民 表达GPC3嵌合抗原受体的iNKT细胞及制备、应用
WO2019024933A1 (zh) * 2017-08-04 2019-02-07 科济生物医药(上海)有限公司 靶向gpc3的car nk细胞
WO2019047932A1 (zh) * 2017-09-08 2019-03-14 科济生物医药(上海)有限公司 基因工程化的t细胞及应用
CN109468279A (zh) * 2017-09-08 2019-03-15 科济生物医药(上海)有限公司 靶向gpc3的免疫效应细胞及其应用
CN109503715B (zh) * 2017-09-15 2023-12-15 科济生物医药(上海)有限公司 Il-4r的融合蛋白及其应用
CN110055275A (zh) * 2018-01-19 2019-07-26 科济生物医药(上海)有限公司 一种质粒载体对、其修饰的免疫细胞及其应用
WO2019149279A1 (zh) 2018-02-02 2019-08-08 科济生物医药(上海)有限公司 细胞免疫治疗的组合
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
CN111989344A (zh) 2018-03-09 2020-11-24 科济生物医药(上海)有限公司 用于治疗肿瘤的方法和组合物
WO2019210863A1 (zh) 2018-05-03 2019-11-07 科济生物医药(上海)有限公司 免疫效应细胞及其应用
CN110438082B (zh) * 2018-05-04 2024-03-08 恺兴生命科技(上海)有限公司 表达il-21r结合蛋白的免疫效应细胞
CN110468105B (zh) * 2018-05-09 2024-03-22 恺兴生命科技(上海)有限公司 表达il-18r结合蛋白的免疫效应细胞
WO2019219029A1 (zh) 2018-05-15 2019-11-21 科济生物医药(上海)有限公司 基因工程化的细胞及应用
CN108441505B (zh) * 2018-05-28 2023-07-07 上海恒润达生生物科技股份有限公司 一种靶向ror1的嵌合抗原受体及其用途
CN110577600B (zh) * 2018-06-07 2021-05-04 中国科学院上海药物研究所 靶向gpc3的抗体-药物偶联物及其制备方法和用途
CN112930199B (zh) 2018-07-24 2024-08-13 恺兴生命科技(上海)有限公司 免疫效应细胞治疗肿瘤的方法
CN110760005A (zh) * 2018-07-25 2020-02-07 上海细胞治疗集团有限公司 一种靶向Glypican-3抗原的嵌合抗原受体修饰T细胞及其用途
CN109021108B (zh) * 2018-08-27 2019-06-25 南京医科大学 抗gpc3全人源化抗体、其嵌合抗原受体细胞及应用
PE20211867A1 (es) * 2018-11-01 2021-09-21 Shandong New Time Pharmaceutical Co Ltd Anticuerpos biespecificos y su uso
CN113164408B (zh) 2018-12-07 2025-07-22 克莱格医学有限公司 肿瘤联合免疫治疗
WO2020118634A1 (zh) * 2018-12-13 2020-06-18 科济生物医药(上海)有限公司 靶向gpc3的免疫效应细胞及其应用
EP3909590A4 (en) 2019-01-07 2022-11-16 CRAGE medical Co., Limited ASSOCIATION FOR CELLULAR IMMUNOTHERAPY
AU2020212534A1 (en) * 2019-01-22 2021-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High affinity monoclonal antibodies targeting glypican-1 and methods of use
JP2022523749A (ja) * 2019-02-01 2022-04-26 クレージュ メディカル カンパニー,リミテッド Tcr融合タンパク質およびtcr融合タンパク質を発現する細胞
CN113891897B (zh) * 2019-03-21 2025-03-25 新加坡科技研究局 组合物
WO2020219715A1 (en) * 2019-04-23 2020-10-29 The Trustees Of The University Of Pennsylvania A dota-binding chimeric antigen receptor for cellular therapy
WO2021110095A1 (zh) * 2019-12-05 2021-06-10 上海翰森生物医药科技有限公司 抗gpc3抗体、其抗原结合片段及其医药用途
CN111187351B (zh) * 2020-04-14 2020-08-04 浙江恒驭生物科技有限公司 一种肝癌检测试剂盒
WO2021213245A1 (zh) * 2020-04-20 2021-10-28 上海翰森生物医药科技有限公司 抗体或其抗原结合片段、其制备方法及医药用途
WO2022028623A1 (zh) 2020-08-07 2022-02-10 佧珐药业有限公司 工程化改造的细胞以及工程化改造细胞的方法
CN114573702A (zh) * 2020-12-02 2022-06-03 康诺亚生物医药科技(成都)有限公司 一种新型肿瘤衔接器治疗药物的开发和应用
KR20220080381A (ko) * 2020-12-07 2022-06-14 (주)이노베이션바이오 Gpc3에 특이적인 항체 및 이의 용도
CN112225822B (zh) * 2020-12-14 2021-03-23 北京基因启明生物科技有限公司 高扩增、存续能力和杀瘤作用的CAR-iNKT及应用
WO2022171100A1 (zh) * 2021-02-10 2022-08-18 江苏先声药业有限公司 Gpc3人源化抗体及其应用
WO2022214089A1 (zh) 2021-04-08 2022-10-13 克莱格医学有限公司 细胞免疫治疗的应用
WO2022218375A1 (zh) * 2021-04-15 2022-10-20 克莱格医学有限公司 嵌合t细胞受体及其应用
US20250269028A1 (en) 2021-06-29 2025-08-28 Carsgen Therapeutics Co., Ltd Chimeric polypeptide for regulating cell physiological activity
CN113527500B (zh) * 2021-07-16 2022-09-20 蒋小滔 一种磷脂酰肌醇蛋白聚糖3的全人源单克隆抗体、其嵌合抗原受体及应用
CN113354737B (zh) * 2021-07-20 2022-11-18 广州爱思迈生物医药科技有限公司 一种磷脂酰肌醇蛋白聚糖3抗体及其应用
KR20240112375A (ko) * 2021-08-19 2024-07-18 아디셋 테라퓨틱스, 인크. 막 결합된 글리피칸-3의 검출 방법
EP4527465A3 (en) 2021-10-15 2025-07-09 Concept to Medicine Biotech Co., Ltd. Anti-glypican 3 antibodies
CN114539410B (zh) * 2022-03-15 2023-09-05 苏州量化细胞生物科技有限公司 Cldn18.2结合抗体、探针及在cldn18.2表达细胞的单细胞测序中的应用
CN119013305A (zh) * 2022-04-24 2024-11-22 昱言科技(北京)有限公司 靶向gpc3的单克隆抗体和包含此抗体的抗体药物缀合物
CN115850492A (zh) * 2022-08-18 2023-03-28 武汉生之源生物科技股份有限公司 一种抗磷脂酰肌醇蛋白多糖-3的单克隆抗体、多核苷酸及其制备方法和应用
JP2025531401A (ja) 2022-09-22 2025-09-19 レプ バイオファーマ カンパニー,リミティド Gpc3抗体薬物複合体及びその使用
CN119894935A (zh) * 2022-09-30 2025-04-25 信立泰(成都)生物技术有限公司 抗gpc3单克隆抗体/双特异性抗体或其抗原结合片段及其用途
WO2025097041A1 (en) * 2023-11-03 2025-05-08 Board Of Regents, The University Of Texas System Methods for the detection and treatment of resistant cancers co-expressing alpp and/or alpg/alppl2
KR20250116580A (ko) * 2024-01-24 2025-08-01 국립암센터 Gpc3에 특이적으로 결합하는 신규 항체를 이용한 키메라 항원 수용체 t 세포
CN119798446B (zh) * 2025-01-06 2025-09-12 百吉生物医药(广州)股份有限公司 一种磷脂酰肌醇蛋白聚糖3单域抗体及其应用
CN119823273B (zh) * 2025-01-08 2025-09-12 百吉生物医药(广州)股份有限公司 一种抗gpc3蛋白纳米抗体及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2208784B1 (en) * 2001-06-22 2013-01-02 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitors containing anti-glypican 3 antibody
WO2004022597A1 (ja) * 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha Gpc3の血中可溶化n端ペプチドに対する抗体
CA2482881C (en) * 2002-05-23 2016-11-08 Sunnybrook And Women's College Health Sciences Centre Diagnosis of hepatocellular carcinoma
DE602005024502D1 (de) * 2004-07-09 2010-12-16 Chugai Pharmaceutical Co Ltd Anti-glypican-3-antikörper
EP1816140A4 (en) * 2004-10-26 2009-09-02 Chugai Pharmaceutical Co Ltd ANTI-GLYPICAN ANTIBODY 3 MODIFIED SWEET CHAIN
US20070087005A1 (en) * 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
US7846443B2 (en) 2006-08-11 2010-12-07 Schering Corporation Antibodies to IL-17A
RS54624B1 (sr) * 2007-07-17 2016-08-31 E. R. Squibb & Sons, L.L.C. Monoklonska antitela protiv glipikana-3
CL2009000647A1 (es) * 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
CN101633693A (zh) * 2009-08-24 2010-01-27 中国人民解放军第二军医大学 一种抗gpc3的单克隆抗体
EP2998320B1 (en) * 2011-04-19 2018-07-18 The United States of America, as represented by the Secretary, Department of Health and Human Services Human monoclonal antibodies specific for glypican-3 and use thereof
US20140322216A1 (en) * 2011-11-08 2014-10-30 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
CN102634486B (zh) * 2012-03-28 2014-12-10 南方医科大学 Gpc3单克隆抗体杂交瘤细胞株7d11及其制备方法和应用
CN103833852A (zh) * 2012-11-23 2014-06-04 上海市肿瘤研究所 针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体
TWI693073B (zh) * 2012-12-21 2020-05-11 日商中外製藥股份有限公司 對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑
CN104140974B (zh) * 2013-05-08 2017-09-29 科济生物医药(上海)有限公司 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞
WO2017186121A1 (zh) * 2016-04-26 2017-11-02 科济生物医药(上海)有限公司 一种改善免疫应答细胞功能的方法

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