SG11201708680PA - Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr) - Google Patents
Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr)Info
- Publication number
- SG11201708680PA SG11201708680PA SG11201708680PA SG11201708680PA SG11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA
- Authority
- SG
- Singapore
- Prior art keywords
- tcr
- activated
- specific
- cells expressing
- cell receptor
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/SG2016/050164 WO2017171631A1 (en) | 2016-03-31 | 2016-03-31 | Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr) |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201708680PA true SG11201708680PA (en) | 2017-11-29 |
Family
ID=59965039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201708680PA SG11201708680PA (en) | 2016-03-31 | 2016-03-31 | Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr) |
Country Status (7)
Country | Link |
---|---|
US (1) | US11576932B2 (zh) |
EP (1) | EP3436572A4 (zh) |
JP (1) | JP2019509753A (zh) |
KR (1) | KR20190006952A (zh) |
CN (2) | CN118147079A (zh) |
SG (1) | SG11201708680PA (zh) |
WO (1) | WO2017171631A1 (zh) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11186624B2 (en) | 2016-09-23 | 2021-11-30 | Lion Tcr Pte. Ltd. | HBV antigen specific binding molecules and fragments thereof |
US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
CN110730821B (zh) | 2016-12-16 | 2023-12-08 | 比莫根生物科技公司 | 增强的hAT家族转座子介导的基因转移及相关组合物、系统和方法 |
US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
US11760983B2 (en) | 2018-06-21 | 2023-09-19 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
CN116144706A (zh) * | 2018-08-13 | 2023-05-23 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
SG11202110956RA (en) | 2019-04-05 | 2021-10-28 | Rootpath Genomics Inc | Compositions and methods for t-cell receptor gene assembly |
WO2021148110A1 (en) | 2020-01-21 | 2021-07-29 | Lion Tcr Pte. Ltd. | Hbv specific tcr library and its use as personalised medicine |
EP4143219A2 (en) * | 2020-04-27 | 2023-03-08 | Vanderbilt University | Lymphocytes lacking perforin function |
US20230338532A1 (en) * | 2020-09-11 | 2023-10-26 | National University Of Singapore | Immunosuppressant drug resistant armored tcr t cells for immune-therapy of organ transplant patients |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002322211A1 (en) * | 2001-07-12 | 2003-01-29 | Canvac | Methods and compisitions for activation human t cells in vitro |
GB0509318D0 (en) * | 2005-05-06 | 2005-06-15 | Chiron Srl | TCR-independent activation of T cells |
CA2608193A1 (en) * | 2005-05-11 | 2006-11-23 | The Trustees Of The University Of Pennsylvania | Methods for the rapid expansion of antigen specific t-cells |
CN101501055B (zh) * | 2005-06-23 | 2016-05-11 | 贝勒医学院 | 负性免疫调节因子的调节和免疫疗法应用 |
EP1795599A1 (en) * | 2005-12-09 | 2007-06-13 | Schuler, Gerold, Prof. Dr. | Methods for generating antigen-specific effector T cells |
CN101361969B (zh) * | 2008-01-29 | 2011-05-11 | 广州市恺泰生物科技有限公司 | 一种治疗性乙肝疫苗及其制备方法和用途 |
ES2622505T3 (es) | 2008-05-09 | 2017-07-06 | Agency For Science, Technology And Research | Receptor de linfocito T (RLT) exógeno reactivo contra epítopo de VHB y usos del mismo |
ES2657846T3 (es) * | 2010-04-29 | 2018-03-07 | Epiontis Gmbh | Detección de células inmunes, en particular linfocitos T mediante análisis de metilación de ADN de los genes CCR6 |
CN104080917B (zh) * | 2011-09-29 | 2016-11-02 | 国家健康与医学研究院 | 用突变体BaEV糖蛋白假型化的慢病毒载体 |
KR102135239B1 (ko) | 2012-08-20 | 2020-07-17 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법을 위한 방법 및 조성물 |
JP2015529685A (ja) * | 2012-09-17 | 2015-10-08 | ザ・リサーチ・インスティテュート・アット・ネイションワイド・チルドレンズ・ホスピタルThe Research Institute Atnationwide Children’S Hospital | 筋萎縮性側索硬化症の処置のための組成物および方法 |
CN102964326B (zh) * | 2012-11-06 | 2015-11-18 | 北京大学 | 具有mek抑制功能的化合物及其制备方法与应用 |
SI3080103T1 (sl) * | 2013-12-11 | 2018-11-30 | Biogen Ma Inc. | Biarilne spojine, ki so uporabne za zdravljenje človeških bolezni na področju onkologije, nevrologije in imunologije |
WO2015091823A1 (en) * | 2013-12-19 | 2015-06-25 | Friedrich-Alexander Universität Erlangen-Nürnberg | Influenza-specific t-cell receptor and its uses in the detection, prevention and/or treatment of influenza |
WO2016036746A1 (en) * | 2014-09-02 | 2016-03-10 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
CN107106670A (zh) * | 2014-10-31 | 2017-08-29 | 宾夕法尼亚大学董事会 | 用于修饰的t细胞的方法和组合物 |
JP7038353B2 (ja) * | 2016-04-13 | 2022-03-18 | ヴィヴィア バイオテック,エス.エル | エクスビボのbite活性化t細胞 |
US11186624B2 (en) * | 2016-09-23 | 2021-11-30 | Lion Tcr Pte. Ltd. | HBV antigen specific binding molecules and fragments thereof |
SG10201705285SA (en) * | 2017-06-27 | 2019-01-30 | Agency Science Tech & Res | Antisense oligonucleotides |
US11903968B2 (en) * | 2017-07-21 | 2024-02-20 | Cellectis | Engineered immune cells resistant to tumor microenvironment |
AU2020226714A1 (en) * | 2019-02-19 | 2021-08-26 | European Molecular Biology Laboratory | Cell penetrating transposase |
CN111607565A (zh) * | 2020-06-04 | 2020-09-01 | 河南大学 | 一种北平顶猴t细胞的体外扩增方法 |
-
2016
- 2016-03-31 SG SG11201708680PA patent/SG11201708680PA/en unknown
- 2016-03-31 US US16/089,809 patent/US11576932B2/en active Active
- 2016-03-31 WO PCT/SG2016/050164 patent/WO2017171631A1/en active Application Filing
- 2016-03-31 EP EP16897247.9A patent/EP3436572A4/en active Pending
- 2016-03-31 KR KR1020187031670A patent/KR20190006952A/ko not_active IP Right Cessation
- 2016-03-31 CN CN202410043623.0A patent/CN118147079A/zh active Pending
- 2016-03-31 CN CN201680086293.7A patent/CN109477073B/zh active Active
- 2016-03-31 JP JP2018551317A patent/JP2019509753A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20190192566A1 (en) | 2019-06-27 |
EP3436572A1 (en) | 2019-02-06 |
WO2017171631A1 (en) | 2017-10-05 |
KR20190006952A (ko) | 2019-01-21 |
JP2019509753A (ja) | 2019-04-11 |
CN118147079A (zh) | 2024-06-07 |
CN109477073B (zh) | 2024-04-12 |
EP3436572A4 (en) | 2019-11-20 |
US11576932B2 (en) | 2023-02-14 |
CN109477073A (zh) | 2019-03-15 |
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