SG11201708579WA - High resolution systems, kits, apparatus, and methods for high throughput microbiology applications - Google Patents

High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

Info

Publication number
SG11201708579WA
SG11201708579WA SG11201708579WA SG11201708579WA SG11201708579WA SG 11201708579W A SG11201708579W A SG 11201708579WA SG 11201708579W A SG11201708579W A SG 11201708579WA SG 11201708579W A SG11201708579W A SG 11201708579WA SG 11201708579W A SG11201708579W A SG 11201708579WA
Authority
SG
Singapore
Prior art keywords
kits
methods
resolution systems
high resolution
high throughput
Prior art date
Application number
SG11201708579WA
Other languages
English (en)
Inventor
Paul C Blainey
Michael W Seely
Roman Stocker
Karsten Zengler
Scott Conradson
Peter Christey
Alexander Hallock
Original Assignee
Gen Automation Lab Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Automation Lab Tech Inc filed Critical Gen Automation Lab Tech Inc
Publication of SG11201708579WA publication Critical patent/SG11201708579WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/24—Gas permeable parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
SG11201708579WA 2015-04-21 2016-04-21 High resolution systems, kits, apparatus, and methods for high throughput microbiology applications SG11201708579WA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562150677P 2015-04-21 2015-04-21
US201662292091P 2016-02-05 2016-02-05
US201662299088P 2016-02-24 2016-02-24
PCT/US2016/028681 WO2016172362A1 (en) 2015-04-21 2016-04-21 High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

Publications (1)

Publication Number Publication Date
SG11201708579WA true SG11201708579WA (en) 2017-11-29

Family

ID=55863246

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201708579WA SG11201708579WA (en) 2015-04-21 2016-04-21 High resolution systems, kits, apparatus, and methods for high throughput microbiology applications

Country Status (10)

Country Link
US (5) US10900073B2 (enExample)
EP (2) EP4070887A1 (enExample)
JP (2) JP6837473B2 (enExample)
CN (2) CN107810277B (enExample)
AU (2) AU2016250591B2 (enExample)
CA (2) CA2981622C (enExample)
DK (1) DK3285926T3 (enExample)
IL (2) IL254858B (enExample)
SG (1) SG11201708579WA (enExample)
WO (1) WO2016172362A1 (enExample)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3013983T (lt) 2013-06-25 2023-05-10 Prognosys Biosciences, Inc. Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį
WO2015175398A1 (en) 2014-05-12 2015-11-19 President And Fellows Of Harvard College Systems and methods for making and using sensors, probes, and other devices
SG11201707515SA (en) 2015-04-10 2017-10-30 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US10865434B2 (en) 2015-04-21 2020-12-15 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods for screening microorganisms and other high throughput microbiology applications
EP4070887A1 (en) * 2015-04-21 2022-10-12 Isolation Bio Inc. Methods for high throughput microbiology applications
US10712356B2 (en) 2015-04-21 2020-07-14 General Automation Lab Technologies Inc. Apparatus and method for picking biological sample
US10788452B2 (en) 2015-04-21 2020-09-29 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods for bacterial community relationship determination and other high throughput microbiology applications
US9938558B2 (en) 2015-06-25 2018-04-10 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
EP3314007B1 (en) 2015-06-25 2024-01-24 Native Microbials, Inc. Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
US10851399B2 (en) 2015-06-25 2020-12-01 Native Microbials, Inc. Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and selecting and synthesizing microbial ensembles based thereon
WO2018126026A1 (en) 2016-12-28 2018-07-05 Ascus Biosciences, Inc. Methods, apparatuses, and systems for analyzing complete microorganism strains in complex heterogeneous communities, determining functional relationships and interactions thereof, and identifying and synthesizing bioreactive modificators based thereon
MX392304B (es) 2016-01-07 2025-03-24 Native Microbials Inc Métodos para mejorar la producción de leche mediante la administración de consorcios microbianos.
US10672601B2 (en) * 2016-06-07 2020-06-02 The Regents Of The University Of California Detecting compounds in microfluidic droplets using mass spectrometry
WO2018005390A1 (en) 2016-06-30 2018-01-04 General Automation Lab Technologies, Inc. High resolution systems, kits, apparatus, and methods using lateral flow for high throughput microbiology applications
WO2018017106A1 (en) 2016-07-21 2018-01-25 Rutgers, The State University Of New Jersey Endophytic bacterium for application to grasses to increase plant growth
WO2018027185A1 (en) 2016-08-04 2018-02-08 Duke University Compositions and methods for measuring bacterial growth
WO2018064385A1 (en) * 2016-09-28 2018-04-05 General Automation Lab Technologies, Inc. High resolution systems, kits, apparatus, and methods for bacterial community relationship determination and other high throughput microbiology applications
CN110168069A (zh) * 2016-10-19 2019-08-23 通用自动化实验技术公司 用于筛选微生物和其他高通量微生物学应用的高分辨率系统、试剂盒、设备和方法
EP3562955A4 (en) 2016-12-28 2020-08-12 Ascus Biosciences, Inc. METHODS, APPARATUS AND SYSTEMS FOR THE ANALYSIS OF STRAINS OF MICRO-ORGANISMS OF HETEROGENEOUS COMMUNITIES COMPLEX WITH TRACEOR ANALYZES, DETERMINATION OF THEIR INTERACTIONS AND FUNCTIONAL RELATIONSHIPS, AND SUMMARY OF MICROBIAL SETS OF MICROBIAL SETS AND MICROBIAL SETS INCLUDING MICROBIAL SETS AND INGREDIENTS
US11305282B2 (en) * 2017-03-29 2022-04-19 Cornell University Devices, processes, and systems for determination of nucleic acid sequence, expression, copy number, or methylation changes using combined nuclease, ligase, polymerase, and sequencing reactions
JP7283846B2 (ja) * 2017-04-12 2023-05-30 アイソレーション バイオ インコーポレイテッド 生体試料を採取するための装置及び方法
US11044924B2 (en) 2017-04-28 2021-06-29 Native Microbials, Inc. Methods for supporting grain intensive and or energy intensive diets in ruminants by administration of a synthetic bioensemble of microbes or purified strains therefor
CN107287293B (zh) * 2017-06-13 2019-07-30 浙江大学 一种环境中微生物群落结构的绝对丰度测定方法
WO2019006436A1 (en) 2017-06-30 2019-01-03 Inscripta, Inc. METHODS, MODULES, INSTRUMENTS AND SYSTEMS FOR AUTOMATED CELL PROCESSING
US10738327B2 (en) 2017-08-28 2020-08-11 Inscripta, Inc. Electroporation cuvettes for automation
WO2019051181A1 (en) 2017-09-08 2019-03-14 President And Fellows Of Harvard College METHODS AND APPARATUSES BASED ON NANOCAPTERS FOR THE DETERMINATION OF ANALYTES
WO2019068022A1 (en) 2017-09-30 2019-04-04 Inscripta, Inc. CONTINUOUS FLOW ELECTROPORATION INSTRUMENTATION
WO2019190874A1 (en) 2018-03-29 2019-10-03 Inscripta, Inc. Automated control of cell growth rates for induction and transformation
WO2019200004A1 (en) 2018-04-13 2019-10-17 Inscripta, Inc. Automated cell processing instruments comprising reagent cartridges
WO2019209926A1 (en) 2018-04-24 2019-10-31 Inscripta, Inc. Automated instrumentation for production of peptide libraries
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
US10557216B2 (en) 2018-04-24 2020-02-11 Inscripta, Inc. Automated instrumentation for production of T-cell receptor peptide libraries
US10752874B2 (en) 2018-08-14 2020-08-25 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US10532324B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US10533152B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
AU2019363487A1 (en) 2018-08-30 2021-04-15 Inscripta, Inc. Improved detection of nuclease edited sequences in automated modules and instruments
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
WO2020141525A1 (en) * 2018-12-31 2020-07-09 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Capture flow assay device and methods
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US12140520B2 (en) 2019-02-27 2024-11-12 NanoMosaic INC. Nanosensors and use thereof
EP3962653A4 (en) * 2019-05-01 2023-09-13 Massachusetts Institute Of Technology MASSIVELY PARALLEL ON-CHIP CONSTRUCTION OF SYNTHETIC MICROBIAN COMMUNITIES
EP3962650A1 (en) * 2019-05-02 2022-03-09 General Automation Lab Technologies Inc. Microfabricated device with hydrophilic microwells and hydrophobic interstitial space
WO2020232425A1 (en) * 2019-05-16 2020-11-19 General Automation Lab Technologies Inc. Method for assaying biological sample on microfabricated chip
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
US10907125B2 (en) 2019-06-20 2021-02-02 Inscripta, Inc. Flow through electroporation modules and instrumentation
EP3986909A4 (en) 2019-06-21 2023-08-02 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
US10927385B2 (en) 2019-06-25 2021-02-23 Inscripta, Inc. Increased nucleic-acid guided cell editing in yeast
US12173361B2 (en) * 2019-07-12 2024-12-24 California Institute Of Technology Rodent model and related device, compositions, methods and systems
WO2021011460A1 (en) * 2019-07-12 2021-01-21 California Institute Of Technology Absolute quantification of nucleic acids and related methods and systems
US20210115367A1 (en) * 2019-10-18 2021-04-22 General Automation Lab Technologies Inc. Use of Resorufin for Monitoring Metabolic Activity of Cells under Anaerobic Condition
US12157124B2 (en) 2019-11-06 2024-12-03 10X Genomics, Inc. Imaging system hardware
CN115038794A (zh) 2019-12-23 2022-09-09 10X基因组学有限公司 在基于分区的测定中使用固定生物样品的组合物和方法
CN121022991A (zh) 2019-12-23 2025-11-28 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
US10689669B1 (en) 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
KR20220133257A (ko) 2020-01-27 2022-10-04 인스크립타 인코포레이티드 전기천공 모듈 및 기구
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en) 2020-02-07 2021-08-12 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US11684914B2 (en) 2020-02-18 2023-06-27 Isolation Bio Inc. Method of transferring material from microfabricated device
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
EP4153984A1 (en) 2020-05-19 2023-03-29 10X Genomics, Inc. Electrophoresis cassettes and instrumentation
ES2989052T3 (es) * 2020-05-22 2024-11-25 10X Genomics Inc Medición espacio-temporal simultánea de la expresión génica y la actividad celular
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
ES2981265T3 (es) 2020-06-08 2024-10-08 10X Genomics Inc Métodos para determinar un margen quirúrgico y métodos de uso del mismo
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
EP4172362B1 (en) 2020-06-25 2024-09-18 10X Genomics, Inc. Spatial analysis of dna methylation
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
ES2993269T3 (en) 2020-09-18 2024-12-26 10X Genomics Inc Sample handling apparatus and image registration methods
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
EP4121555A1 (en) 2020-12-21 2023-01-25 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
CN112553064A (zh) * 2020-12-24 2021-03-26 广东省微生物研究所（广东省微生物分析检测中心） 一种高通量筛选具有潜在生物防腐功能活性菌株的装置及方法
EP4421491A3 (en) 2021-02-19 2024-11-27 10X Genomics, Inc. Method of using a modular assay support device
CN113083383B (zh) * 2021-03-18 2022-10-25 华中农业大学 微流控芯片装置、制备方法及土壤微生物群落培养方法
EP4428246B1 (en) 2021-04-14 2025-12-24 10X Genomics, Inc. Methods of measuring mislocalization of an analyte
WO2022236054A1 (en) 2021-05-06 2022-11-10 10X Genomics, Inc. Methods for increasing resolution of spatial analysis
EP4582555A3 (en) 2021-06-03 2025-10-22 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
ES3011462T3 (en) 2021-09-01 2025-04-07 10X Genomics Inc Methods for blocking a capture probe on a spatial array
USD1064308S1 (en) 2021-09-17 2025-02-25 10X Genomics, Inc. Sample handling device
CN118103521A (zh) * 2021-10-20 2024-05-28 深圳华大生命科学研究院 筛选药物的方法
EP4419707A1 (en) 2021-11-10 2024-08-28 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
EP4305195A2 (en) 2021-12-01 2024-01-17 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
WO2023122033A1 (en) 2021-12-20 2023-06-29 10X Genomics, Inc. Self-test for pathology/histology slide imaging device
US20240141278A1 (en) 2022-11-02 2024-05-02 Fujifilm Corporation Pattern forming device and pattern forming method

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE8137962U1 (de) * 1981-12-28 1982-06-16 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Mikrotiterplatte zur blutgruppendiagnostik
US4634676A (en) 1984-06-06 1987-01-06 Becton, Dickinson And Company Replica plating device
US4717667A (en) * 1984-07-11 1988-01-05 Fmc Corporation Colony replicating device
US5061621A (en) 1989-06-22 1991-10-29 Brandeis University Replica plating device with an integral marking element
AUPN154295A0 (en) 1995-03-06 1995-03-30 Commonwealth Scientific And Industrial Research Organisation Nucleic acid molecule encoding a protein with avian gamma-interferon activity
US5587322A (en) 1994-11-23 1996-12-24 Replicatech, Inc. Replica plating device
US5985594A (en) 1995-11-14 1999-11-16 Idexx Laboratories, Inc. Method for quantification of biological material in a sample
US20030215798A1 (en) 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
US6972183B1 (en) 1997-06-16 2005-12-06 Diversa Corporation Capillary array-based enzyme screening
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5882922A (en) 1997-03-19 1999-03-16 Becton Dickinson And Company Culture vessel assembly
US7019827B2 (en) 1997-06-16 2006-03-28 Diversa Corporation GigaMatrix holding tray having through-hole wells
US20050070005A1 (en) 1997-06-16 2005-03-31 Martin Keller High throughput or capillary-based screening for a bioactivity or biomolecule
US5858770A (en) 1997-09-30 1999-01-12 Brandeis University Cell culture plate with oxygen and carbon dioxide-permeable waterproof sealing membrane
US6900055B1 (en) 1998-10-28 2005-05-31 Cellon S.A. Preparation of porous silicone rubber for growing cells or living tissue
US6455310B1 (en) * 1999-03-23 2002-09-24 Biocrystal Ltd. Cell culture apparatus and method for culturing cells
CA2319205A1 (en) 2000-03-13 2001-09-13 The State Of Oregon Acting By And Through The State Board Of Higher Educ Ation On Behalf Of Oregon State University High-throughput microbial culturing
US6638730B2 (en) 2001-03-06 2003-10-28 Council Of Scientific & Industrial Research Composition for qualitative screening of phosphate solubilizing microorganisms and a qualitative method for screening microorganisms
US7011957B2 (en) 2001-09-26 2006-03-14 Northeastern University Isolation and cultivation of microorganisms from natural environments and drug discovery based thereon
AU2002360361A1 (en) 2001-11-09 2003-06-10 Biomicroarrays, Inc. High surface area substrates for microarrays and methods to make same
AU2003223416A1 (en) * 2002-03-25 2003-10-13 Condros, Inc. Tissue analogs for in vitro testing and method of use therefor
JP2005528102A (ja) 2002-06-03 2005-09-22 パムジーン ビー．ブイ． 多用途の生存マイクロアレイを用いる、細胞に基づく高処理量アッセイのための方法
WO2004033617A1 (de) 2002-09-16 2004-04-22 Pan - Biotech Gmbh Zellkulturkammer für ein zellkultursystem
JP3723882B2 (ja) * 2002-11-14 2005-12-07 篤 村口 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法
WO2005052582A2 (en) 2003-11-28 2005-06-09 Pamgene B.V. Methods and apparatus for cell based microarray assays
EP1758981A4 (en) 2004-05-28 2013-01-16 Wafergen Inc DEVICES AND METHOD FOR MULTIPLEX ANALYZES
US20090042736A1 (en) 2005-04-18 2009-02-12 Johan Gerrit Bomer Biochip and process for the production of a biochip
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
WO2007035633A2 (en) * 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
WO2007120208A2 (en) 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
DE102006030068A1 (de) * 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
WO2008103339A2 (en) 2007-02-22 2008-08-28 Corning Incorporated Substrates useful for cell culture and methods for making and using same
US9328172B2 (en) * 2008-04-05 2016-05-03 Single Cell Technology, Inc. Method of obtaining antibodies of interest and nucleotides encoding same
WO2009148509A1 (en) * 2008-05-30 2009-12-10 Corning Incorporated Cell culture apparatus having different micro-well topography
US8114646B2 (en) 2008-05-30 2012-02-14 Corning Incorporated Method for ultrasonic cell removal
WO2010040831A1 (en) * 2008-10-10 2010-04-15 Picovitro Ab Genetic analysis in microwells
WO2010093766A1 (en) 2009-02-11 2010-08-19 The University Of North Carolina At Chapel Hill Method and device for cell selection and collection in an isolated culturing environment
US9243290B2 (en) 2009-10-09 2016-01-26 Stc.Unm Polony sequencing methods
EP2504103A2 (en) 2009-11-23 2012-10-03 3M Innovative Properties Company Microwell array articles and methods of use
US9234229B2 (en) 2009-12-08 2016-01-12 The Board Of Trustees Of The Leland Stanford Junior University High throughput system for isolation, growth, and detection of lipid inclusions in bacteria
EP2536819B1 (en) 2010-02-16 2024-12-18 The University of North Carolina at Chapel Hill Array of micromolded structures for collecting or culturing of cells
US20130115606A1 (en) * 2010-07-07 2013-05-09 The University Of British Columbia System and method for microfluidic cell culture
EP2407242A1 (en) * 2010-07-13 2012-01-18 Dublin City University Direct clone analysis and selection technology
KR20200113286A (ko) 2010-12-22 2020-10-06 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
US9095852B2 (en) 2011-08-22 2015-08-04 The Regents Of The University Of California Multilayer high density microwells
WO2013059884A1 (en) * 2011-10-28 2013-05-02 Itek Ventures Pty Ltd A gene and mutations thereof associated with seizure and movement disorders
EP2823064B1 (en) 2012-03-05 2019-02-06 President and Fellows of Harvard College Methods for epigenetic sequencing
US20130295551A1 (en) 2012-03-29 2013-11-07 The Board Of Trustees Of The University Of Illinois Microfluidic device and method for modulating a gas environment of cell cultures and tissues
CA2873585C (en) 2012-05-14 2021-11-09 Cb Biotechnologies, Inc. Method for increasing accuracy in quantitative detection of polynucleotides
DK2861760T3 (da) 2012-06-15 2020-03-09 Univ Texas Sekventering med høj kapacitet af flere udskrifter af en enkelt celle
US9657290B2 (en) * 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
EP2885418A4 (en) * 2012-08-14 2016-03-02 10X Genomics Inc MICROCAPSE COMPOSITIONS AND METHOD THEREFOR
EP4148118A1 (en) 2012-08-24 2023-03-15 Yale University System, device and method for high-throughput multi-plexed detection
PT2925782T (pt) * 2012-12-03 2020-04-22 Novimmune Sa Anticorpos anti-cd47 e métodos de utilização destes
KR20230003659A (ko) 2013-02-08 2023-01-06 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
EP2805769A1 (en) * 2013-05-24 2014-11-26 European Molecular Biology Laboratory Methods for nano-scale single cell analysis
US20160122753A1 (en) 2013-06-12 2016-05-05 Tarjei Mikkelsen High-throughput rna-seq
US20150017714A1 (en) 2013-07-02 2015-01-15 Miltenyi Biotec Gmbh Centrifugation chamber with gas permeable membrane layers for cell cultivation
AU2014312208B2 (en) * 2013-08-28 2019-07-25 Becton, Dickinson And Company Massively parallel single cell analysis
US20150118707A1 (en) 2013-10-25 2015-04-30 Ponnambalam Selvaganapathy Method and device for detecting metabollically active cells
EP3194593B1 (en) 2014-09-15 2019-02-06 AbVitro LLC High-throughput nucleotide library sequencing
US20170247652A1 (en) 2014-10-20 2017-08-31 Northeastern University Device and Method for High Throughput Bacterial Isolation
JP6920997B2 (ja) 2015-02-22 2021-08-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー マイクロスクリーニング装置、プロセス、及び生成物
EP3261761B1 (en) 2015-02-27 2022-04-13 Corning Incorporated Fitted lid for multi-well plate
US10788452B2 (en) * 2015-04-21 2020-09-29 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods for bacterial community relationship determination and other high throughput microbiology applications
US10677793B2 (en) 2015-04-21 2020-06-09 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods using lateral flow for high throughput microbiology applications
US20180023045A1 (en) * 2015-04-21 2018-01-25 General Automation Lab Technologies, Inc. High resolution systems, kits, apparatus, and methods using combinatorial media strategies for high throughput microbiology applications
US10590461B2 (en) * 2015-04-21 2020-03-17 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods using magnetic beads for high throughput microbiology applications
US10865434B2 (en) * 2015-04-21 2020-12-15 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods for screening microorganisms and other high throughput microbiology applications
US10712356B2 (en) * 2015-04-21 2020-07-14 General Automation Lab Technologies Inc. Apparatus and method for picking biological sample
EP4070887A1 (en) * 2015-04-21 2022-10-12 Isolation Bio Inc. Methods for high throughput microbiology applications
US10934538B2 (en) 2016-01-12 2021-03-02 Cleveland State University 3D-printed miniature biological constructs

Also Published As

Publication number Publication date
CN107810277A (zh) 2018-03-16
CA2981622A1 (en) 2016-10-27
JP6837473B2 (ja) 2021-03-03
AU2016250591A1 (en) 2017-10-26
US20190194735A1 (en) 2019-06-27
US11104939B2 (en) 2021-08-31
IL254858A0 (en) 2017-12-31
US11136621B2 (en) 2021-10-05
AU2016250591B2 (en) 2021-08-05
CN107810277B (zh) 2021-11-02
CN114015569A (zh) 2022-02-08
US10900073B2 (en) 2021-01-26
JP2018515133A (ja) 2018-06-14
IL254858B (en) 2021-12-01
AU2021257901A1 (en) 2021-11-18
EP3285926B1 (en) 2022-03-02
EP4070887A1 (en) 2022-10-12
CA2981622C (en) 2023-02-07
IL287247B2 (en) 2023-07-01
JP2020195385A (ja) 2020-12-10
US20190194736A1 (en) 2019-06-27
US20160312275A1 (en) 2016-10-27
WO2016172362A1 (en) 2016-10-27
DK3285926T3 (da) 2022-05-09
US20180051327A1 (en) 2018-02-22
IL287247A (en) 2021-12-01
CA3184363C (en) 2024-01-02
IL287247B1 (en) 2023-03-01
CA3184363A1 (en) 2016-10-27
EP3285926A1 (en) 2018-02-28
US10227640B2 (en) 2019-03-12
US11104940B2 (en) 2021-08-31
US20190194734A1 (en) 2019-06-27

Similar Documents

Publication Publication Date Title
IL287247A (en) High-resolution systems, kits, devices and methods for high-throughput microbiology applications
GB2594423B (en) System, apparatus and method
EP3294503A4 (en) Systems, methods and apparatus for guided tools
EP3369683A4 (en) Item transfer apparatus, item inspection apparatus, item transfer method, and item inspection method
EP3132591A4 (en) Systems, apparatus and methods for improved authentication
EP3213094A4 (en) System, method and apparatus for grid location
EP3185513A4 (en) Service processing method, apparatus and server
EP3116177A4 (en) Service implementation method for nfv system, and communications unit
EP3148149A4 (en) Service flow processing method, apparatus and device
GB2548497B (en) Apparatus, method and system for sparse detector
EP3213081A4 (en) System, method and apparatus for pathogen detection
EP3141432A4 (en) Inspection device, inspection system, and inspection method
GB201802233D0 (en) Defect discrimination apparatus, methods, and systems
EP3232633A4 (en) Service processing method and apparatus, and service server
EP3106857A4 (en) Particle sorting apparatus, particle sorting method, program, and particle sorting system
IL266043A (en) High resolution systems, kits, apparatus, and methods for screening microorganisms and other high throughput microbiology applications
GB201608270D0 (en) Method, system and apparatus
EP3162584A4 (en) Image-forming apparatus, image-forming system and image-forming method
EP3334117A4 (en) Method, apparatus and system for quantizing defence result
EP3229530A4 (en) Access method, apparatus and system
IL265540A (en) High resolution systems, kits, apparatus, and methods for bacterial community relationship determination and other high throughput microbiology applications
EP3261386A4 (en) Service processing method, related device and system
EP3115773A4 (en) Inspection device, method and system
EP3210417A4 (en) Method, apparatus and system
EP3268857A4 (en) Systems, methods, and apparatus for reverse geocoding