SG11201708068PA - Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof - Google Patents

Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Info

Publication number
SG11201708068PA
SG11201708068PA SG11201708068PA SG11201708068PA SG11201708068PA SG 11201708068P A SG11201708068P A SG 11201708068PA SG 11201708068P A SG11201708068P A SG 11201708068PA SG 11201708068P A SG11201708068P A SG 11201708068PA SG 11201708068P A SG11201708068P A SG 11201708068PA
Authority
SG
Singapore
Prior art keywords
methods
active agent
extended release
injectable formulations
isoxazoline active
Prior art date
Application number
SG11201708068PA
Other languages
English (en)
Inventor
Susan Mancini Cady
Peter Cheifetz
Izabela Galeska
Fallois Loic Le Hir De
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Publication of SG11201708068PA publication Critical patent/SG11201708068PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SG11201708068PA 2015-04-08 2016-04-06 Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof SG11201708068PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562144871P 2015-04-08 2015-04-08
PCT/US2016/026253 WO2016164487A1 (en) 2015-04-08 2016-04-06 Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Publications (1)

Publication Number Publication Date
SG11201708068PA true SG11201708068PA (en) 2017-10-30

Family

ID=57072717

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201912724SA SG10201912724SA (en) 2015-04-08 2016-04-06 Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
SG11201708068PA SG11201708068PA (en) 2015-04-08 2016-04-06 Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201912724SA SG10201912724SA (en) 2015-04-08 2016-04-06 Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Country Status (18)

Country Link
US (2) US20170020848A1 (zh)
EP (1) EP3280413A1 (zh)
JP (2) JP6824900B2 (zh)
KR (1) KR102593069B1 (zh)
CN (1) CN108055825B (zh)
AR (1) AR104212A1 (zh)
AU (3) AU2016246598B2 (zh)
BR (1) BR112017021073A2 (zh)
CA (1) CA2981797C (zh)
CL (1) CL2017002536A1 (zh)
CO (1) CO2017010065A2 (zh)
EA (2) EA202090762A1 (zh)
IL (1) IL254813B (zh)
MX (2) MX2017012848A (zh)
NZ (1) NZ736374A (zh)
SG (2) SG10201912724SA (zh)
UY (1) UY36610A (zh)
WO (1) WO2016164487A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY37137A (es) * 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
WO2018187623A1 (en) * 2017-04-05 2018-10-11 Merial, Inc. Crystalline forms of (s)-afoxolaner
WO2018189314A1 (en) 2017-04-13 2018-10-18 Ceva Sante Animale Composition for treating worms infestations
BR112020008848A2 (pt) 2017-11-07 2020-10-20 Intervet International B.V. processo de preparação de partículas de isoxazolina de tamanho grande
CA3081646C (en) 2017-11-07 2024-03-19 Intervet International B.V. Injectable isoxazoline pharmaceutical compositions and uses thereof
CA3083683A1 (en) * 2017-12-12 2019-06-20 Intervet International B.V. Implantable isoxazoline pharmaceutical compositions and uses thereof
TWI812673B (zh) * 2018-02-12 2023-08-21 美商富曼西公司 用於防治無脊椎害蟲之萘異噁唑啉化合物
WO2020225143A1 (en) 2019-05-03 2020-11-12 Intervet International B.V. Injectable pharmaceutical compositions and uses thereof
DK4153133T3 (da) 2020-05-20 2024-02-05 Intervet Int Bv Injicerbare farmaceutiske sammensætninger og anvendelser deraf
EP4367112A1 (en) 2021-07-09 2024-05-15 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740421A (en) 1966-09-19 1973-06-19 Basf Wyandotte Corp Polyoxyethylene-polyoxypropylene aqueous gels
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
JPS4914624A (zh) 1972-06-08 1974-02-08
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
DE3681465D1 (zh) 1985-02-04 1991-10-24 Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
RU2024527C1 (ru) 1986-03-25 1994-12-15 Санкио Компани Лимитед Способ получения макролидных соединений
EP0252879B1 (de) 1986-07-02 1992-05-06 Ciba-Geigy Ag Pestizide
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
US5330768A (en) 1991-07-05 1994-07-19 Massachusetts Institute Of Technology Controlled drug delivery using polymer/pluronic blends
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
US6733767B2 (en) * 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
ES2526614T3 (es) 2004-03-05 2015-01-13 Nissan Chemical Industries, Ltd. Compuesto de benzamida sustituida con isoxazolina y agente de control de organismos nocivos
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
CA2621228C (en) 2005-09-02 2014-05-27 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pesticide
US20090143410A1 (en) 2005-12-14 2009-06-04 Kanu Maganbhai Patel Isoxazolines for Controlling Invertebrate Pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
BRPI0710403A2 (pt) 2006-04-20 2011-08-09 Du Pont composto composição, composição de controle, de pulverização, de isca, dispositivo de armadilha, métodos de controle, métodos de proteção, semente tratada, composição de proteção
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
AU2008235089B8 (en) 2007-04-10 2014-04-10 Bayer Intellectual Property Gmbh Insecticidal aryl isoxazoline derivatives
MX2009013469A (es) 2007-06-13 2010-01-20 Du Pont Insecticidas de isoxazolina.
TWI430995B (zh) * 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
TWI556741B (zh) * 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
MX2010003557A (es) 2007-10-03 2010-04-12 Du Pont Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados.
EP2306837B2 (en) 2008-07-09 2023-10-25 Basf Se Pesticidal active mixtures comprising isoxazoline compounds i
CA2747060A1 (en) * 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
PL2513104T3 (pl) * 2009-12-17 2016-08-31 Merial Inc Przeciwpasożytnicze związki dihydroazolu i zawierające je kompozycje
CA2799963C (en) 2010-05-27 2018-01-23 E. I. Du Pont De Nemours And Company Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4,5 -dihydro-5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [(2,2,2-trifluoroethyl)amino]ethyl] -1-naphthalenecarboxamide
DK178277B1 (da) * 2010-06-18 2015-10-26 Novartis Tiergesundheit Ag Diaryloxazolinforbindelser til bekæmpelse af fiskelus
EP2658541B1 (en) 2010-12-27 2022-01-26 Intervet International B.V. Topical localized isoxazoline formulation comprising glycofurol
AR085354A1 (es) * 2011-02-10 2013-09-25 Novartis Ag Derivados de isoxazol para control de pestes invertebrados
AR085657A1 (es) 2011-03-10 2013-10-16 Novartis Ag Compuestos de isoxazol
BR112013023068B8 (pt) 2011-03-10 2022-11-22 Zoetis Llc Derivados de isoxazolina espirocíclica, seu uso e seu processo de preparação, e composições veterinárias
DK3172964T3 (da) * 2011-09-12 2020-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasitiske sammensætninger indeholdende et isoxazolinaktivstof, fremgangsmåde og anvendelser deraf
AR088669A1 (es) * 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
AR088668A1 (es) * 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
BR122020002199B1 (pt) * 2011-12-02 2021-01-19 Merial, Inc. formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina
MD20170009A2 (ro) 2012-02-06 2017-07-31 Merial Limited Compoziţii veterinare antiparazitare orale cu conţinut de agenţi activi cu acţiune sistemică, metode şi aplicări ale acestora
RS59297B1 (sr) * 2012-09-07 2019-10-31 Zoetis Services Llc Paraziticidalne kombinacije spirocikličnog izoksazolina
CA2882546A1 (en) 2012-09-07 2014-03-13 Zoetis Llc Spirocyclic isoxazolines as antiparasitic agents
WO2014189837A1 (en) 2013-05-20 2014-11-27 Zoetis Llc Long-acting spiro-isoxazoline antiparasitic compositions
CN105579029B (zh) * 2013-09-30 2019-03-05 硕腾服务有限责任公司 长效螺异恶唑啉制剂

Also Published As

Publication number Publication date
CO2017010065A2 (es) 2018-01-05
AU2022202035A1 (en) 2022-04-14
JP2021050206A (ja) 2021-04-01
KR20170134700A (ko) 2017-12-06
MX2022010831A (es) 2022-09-29
UY36610A (es) 2016-10-31
MX2017012848A (es) 2018-01-15
EA036272B1 (ru) 2020-10-21
BR112017021073A2 (pt) 2018-07-03
NZ736374A (en) 2024-02-23
IL254813B (en) 2020-03-31
EA201792235A1 (ru) 2018-01-31
JP2018510897A (ja) 2018-04-19
AU2016246598A1 (en) 2017-11-02
AU2020210266B2 (en) 2022-03-10
AU2020210266A1 (en) 2020-08-20
AR104212A1 (es) 2017-07-05
US20210299104A1 (en) 2021-09-30
JP6824900B2 (ja) 2021-02-03
SG10201912724SA (en) 2020-02-27
CN108055825B (zh) 2021-03-30
US20170020848A1 (en) 2017-01-26
IL254813A0 (en) 2017-12-31
AU2016246598B2 (en) 2020-07-23
CN108055825A (zh) 2018-05-18
KR102593069B1 (ko) 2023-10-23
CA2981797A1 (en) 2016-10-13
CL2017002536A1 (es) 2018-04-20
EP3280413A1 (en) 2018-02-14
CA2981797C (en) 2023-11-21
WO2016164487A1 (en) 2016-10-13
EA202090762A1 (ru) 2020-09-08

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