SG10201912724SA - Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof - Google Patents
Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereofInfo
- Publication number
- SG10201912724SA SG10201912724SA SG10201912724SA SG10201912724SA SG10201912724SA SG 10201912724S A SG10201912724S A SG 10201912724SA SG 10201912724S A SG10201912724S A SG 10201912724SA SG 10201912724S A SG10201912724S A SG 10201912724SA SG 10201912724S A SG10201912724S A SG 10201912724SA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- active agent
- extended release
- injectable formulations
- isoxazoline active
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562144871P | 2015-04-08 | 2015-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912724SA true SG10201912724SA (en) | 2020-02-27 |
Family
ID=57072717
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912724SA SG10201912724SA (en) | 2015-04-08 | 2016-04-06 | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| SG11201708068PA SG11201708068PA (en) | 2015-04-08 | 2016-04-06 | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201708068PA SG11201708068PA (en) | 2015-04-08 | 2016-04-06 | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20170020848A1 (en) |
| EP (1) | EP3280413A1 (en) |
| JP (2) | JP6824900B2 (en) |
| KR (1) | KR102593069B1 (en) |
| CN (1) | CN108055825B (en) |
| AR (1) | AR104212A1 (en) |
| AU (3) | AU2016246598B2 (en) |
| BR (1) | BR112017021073A2 (en) |
| CA (1) | CA2981797C (en) |
| CL (1) | CL2017002536A1 (en) |
| CO (1) | CO2017010065A2 (en) |
| EA (2) | EA202090762A1 (en) |
| IL (1) | IL254813B (en) |
| MX (2) | MX2017012848A (en) |
| NZ (1) | NZ736374A (en) |
| SG (2) | SG10201912724SA (en) |
| UY (1) | UY36610A (en) |
| WO (1) | WO2016164487A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY37137A (en) * | 2016-02-24 | 2017-09-29 | Merial Inc | ANTIPARASITARY COMPOUNDS OF ISOXAZOLINE, INJECTABLE FORMULATIONS OF PROLONGED ACTION THAT INCLUDE THEM, METHODS AND USES OF THE SAME |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| CA3059114A1 (en) * | 2017-04-05 | 2018-10-11 | Boehringer Ingelheim Animal Health USA Inc. | Crystalline forms of (s)-afoxolaner |
| EP3609470B1 (en) | 2017-04-13 | 2023-11-22 | Ceva Santé Animale | Implant for treating parasites infestations |
| CN111295375A (en) | 2017-11-07 | 2020-06-16 | 英特维特国际股份有限公司 | Method for producing large-size isoxazoline particles |
| PE20201150A1 (en) | 2017-11-07 | 2020-10-26 | Intervet Int Bv | INJECTABLE PHARMACEUTICAL COMPOSITIONS OF ISOXAZOLINE AND USES OF THE SAME |
| CA3083683A1 (en) * | 2017-12-12 | 2019-06-20 | Intervet International B.V. | Implantable isoxazoline pharmaceutical compositions and uses thereof |
| TWI812673B (en) * | 2018-02-12 | 2023-08-21 | 美商富曼西公司 | Naphthalene isoxazoline compounds for controlling invertebrate pests |
| AR116524A1 (en) * | 2018-10-04 | 2021-05-19 | Elanco Tiergesundheit Ag | HELMINTOS TREATMENT POTENTIAL |
| MX2021013429A (en) | 2019-05-03 | 2021-12-10 | Intervet Int Bv | Injectable pharmaceutical compositions and uses thereof. |
| PT4153133T (en) | 2020-05-20 | 2024-01-12 | Intervet Int Bv | Injectable pharmaceutical compositions and uses thereof |
| KR20240035820A (en) | 2021-07-09 | 2024-03-18 | 플렉시움 인코포레이티드 | Aryl compounds and pharmaceutical compositions that modulate IKZF2 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740421A (en) | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| JPS4914624A (en) | 1972-06-08 | 1974-02-08 | ||
| SE434277B (en) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS |
| US4134973A (en) | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| DE3681465D1 (en) | 1985-02-04 | 1991-10-24 | Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp | |
| EP0237482A1 (en) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | Derivatives of C(29)-carbonyloxy-milbemycine against parasites in animals and plants |
| AR243191A1 (en) | 1986-03-25 | 1993-07-30 | Sankyo Co | A procedure for preparing macrolide compounds. |
| EP0252879B1 (en) | 1986-07-02 | 1992-05-06 | Ciba-Geigy Ag | Pesticides |
| US4855317A (en) | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4871719A (en) | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
| US4874749A (en) | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| EP0319142B1 (en) | 1987-11-03 | 1994-04-06 | Beecham Group Plc | Intermediates for the preparation of anthelmintic macrolide antibiotics |
| NZ232422A (en) | 1989-02-16 | 1992-11-25 | Merck & Co Inc | 13-ketal milbemycin derivatives and parasiticides |
| NZ247278A (en) | 1991-02-12 | 1995-03-28 | Ancare Distributors | Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier |
| US5330768A (en) | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
| US5345377A (en) | 1992-10-30 | 1994-09-06 | Electric Power Research Institute, Inc. | Harmonic controller for an active power line conditioner |
| GB9300883D0 (en) | 1993-01-18 | 1993-03-10 | Pfizer Ltd | Antiparasitic agents |
| AUPM969994A0 (en) | 1994-11-28 | 1994-12-22 | Virbac S.A. | Equine anthelmintic formulations |
| US6207647B1 (en) | 1997-07-18 | 2001-03-27 | Smithkline Beecham Corporation | RatA |
| ES2359973T3 (en) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES. |
| JP4883296B2 (en) | 2004-03-05 | 2012-02-22 | 日産化学工業株式会社 | Isoxazoline-substituted benzamide compounds and pest control agents |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| JP5293921B2 (en) | 2005-09-02 | 2013-09-18 | 日産化学工業株式会社 | Isoxazoline-substituted benzamide compounds and pest control agents |
| AU2006326449A1 (en) | 2005-12-14 | 2007-06-21 | E. I. Du Pont De Nemours And Company | Isoxazolines for controlling invertebrate pests |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (en) | 2005-12-30 | 2013-10-21 | Du Pont | Isoxazolines for controlling invertebrate pests |
| KR20090005201A (en) | 2006-04-20 | 2009-01-12 | 이 아이 듀폰 디 네모아 앤드 캄파니 | Pyrazolines for controlling invertebrate pests |
| JP2008044880A (en) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | Insecticidal isooxazolines |
| JP5256753B2 (en) | 2007-03-29 | 2013-08-07 | 住友化学株式会社 | Isoxazoline compounds and their pest control applications |
| EP2181100A2 (en) | 2007-04-10 | 2010-05-05 | Bayer CropScience AG | Insecticidal aryl isoxazoline derivatives |
| JP5473906B2 (en) | 2007-06-13 | 2014-04-16 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Isoxazoline insecticide |
| TWI430995B (en) * | 2007-06-26 | 2014-03-21 | Du Pont | Naphthalene isoxazoline invertebrate pest control agents |
| TWI556741B (en) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | Isoxazoline compositions and their use as antiparasitics |
| US8367584B2 (en) | 2007-10-03 | 2013-02-05 | E.I. Du Pont De Nemours And Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
| KR101680912B1 (en) | 2008-07-09 | 2016-11-29 | 바스프 에스이 | Pestcidal active mixtures comprising isoxazoline compounds i |
| CA2747060A1 (en) * | 2008-12-18 | 2010-07-15 | Novartis Ag | Isoxazolines derivatives and their use as pesticide |
| KR101920201B1 (en) * | 2009-12-17 | 2018-11-21 | 메리얼 인코포레이티드 | Antiparisitic dihydroazole compounds and compositions comprising same |
| KR102060464B1 (en) | 2010-05-27 | 2019-12-30 | 이 아이 듀폰 디 네모아 앤드 캄파니 | Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-n-[2-0x0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide |
| DK178277B1 (en) * | 2010-06-18 | 2015-10-26 | Novartis Tiergesundheit Ag | Diaryloxazoline compounds for the control of fish lice |
| CN103260620A (en) | 2010-12-27 | 2013-08-21 | 英特维特国际股份有限公司 | Topical localized isoxazoline formulation comprising glycofurol |
| MX2013009211A (en) * | 2011-02-10 | 2013-08-29 | Novartis Ag | Isoxazoline derivatives for controlling invertebrate pests. |
| WO2012120399A1 (en) | 2011-03-10 | 2012-09-13 | Pfizer Inc. | Spirocyclic isoxazoline derivatives as antiparasitic agents |
| AR085657A1 (en) * | 2011-03-10 | 2013-10-16 | Novartis Ag | ISOXAZOL COMPOUNDS |
| TWI567064B (en) * | 2011-09-12 | 2017-01-21 | 龍馬躍有限公司 | Parasiticidal compositions comprising an isoxazoline active agent, methods and uses thereof |
| AR088668A1 (en) * | 2011-11-21 | 2014-06-25 | Lilly Co Eli | SMALL MOLECULES CONTAINING BORO |
| AR088669A1 (en) * | 2011-11-21 | 2014-06-25 | Lilly Co Eli | DERIVATIVES OF DIHYDRODIBENZO [C] [1,2] OXABOROL AND DIHYDROISOXAZOL USEFUL FOR THE CONTROL OF ECTOPARASITES |
| ES2659159T3 (en) * | 2011-12-02 | 2018-03-14 | Merial, Inc. | Long acting injectable moxidectin formulations and new crystalline forms of moxidectin |
| HUE041514T2 (en) | 2012-02-06 | 2019-05-28 | Merial Inc | Parasiticidal oral veterinary compositions comprising systemically acting active agents, methods and uses thereof |
| RS59297B1 (en) | 2012-09-07 | 2019-10-31 | Zoetis Services Llc | Spirocyclic isoxazoline parasiticidal combinations |
| WO2014039484A1 (en) | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazolines as antiparasitic agents |
| EP2999339B1 (en) | 2013-05-20 | 2019-06-19 | Zoetis Services LLC | Long-acting spiro-isoxazoline antiparasitic compositions |
| JP6209272B2 (en) * | 2013-09-30 | 2017-10-04 | ゾエティス・サービシーズ・エルエルシー | Long-acting spiroisoxazoline formulation |
-
2016
- 2016-04-06 SG SG10201912724SA patent/SG10201912724SA/en unknown
- 2016-04-06 AU AU2016246598A patent/AU2016246598B2/en active Active
- 2016-04-06 EP EP16720949.3A patent/EP3280413A1/en active Pending
- 2016-04-06 EA EA202090762A patent/EA202090762A1/en unknown
- 2016-04-06 JP JP2017553068A patent/JP6824900B2/en active Active
- 2016-04-06 NZ NZ736374A patent/NZ736374A/en unknown
- 2016-04-06 SG SG11201708068PA patent/SG11201708068PA/en unknown
- 2016-04-06 MX MX2017012848A patent/MX2017012848A/en unknown
- 2016-04-06 CA CA2981797A patent/CA2981797C/en active Active
- 2016-04-06 EA EA201792235A patent/EA036272B1/en not_active IP Right Cessation
- 2016-04-06 KR KR1020177032205A patent/KR102593069B1/en active IP Right Grant
- 2016-04-06 WO PCT/US2016/026253 patent/WO2016164487A1/en active Application Filing
- 2016-04-06 CN CN201680031640.6A patent/CN108055825B/en active Active
- 2016-04-06 BR BR112017021073A patent/BR112017021073A2/en not_active Application Discontinuation
- 2016-04-06 US US15/092,491 patent/US20170020848A1/en not_active Abandoned
- 2016-04-08 AR ARP160100953A patent/AR104212A1/en active IP Right Grant
- 2016-04-08 UY UY0001036610A patent/UY36610A/en active IP Right Grant
-
2017
- 2017-10-01 IL IL254813A patent/IL254813B/en active IP Right Grant
- 2017-10-04 CO CONC2017/0010065A patent/CO2017010065A2/en unknown
- 2017-10-05 MX MX2022010831A patent/MX2022010831A/en unknown
- 2017-10-06 CL CL2017002536A patent/CL2017002536A1/en unknown
-
2020
- 2020-07-30 AU AU2020210266A patent/AU2020210266B2/en active Active
- 2020-11-20 JP JP2020193357A patent/JP2021050206A/en active Pending
-
2021
- 2021-05-24 US US17/327,929 patent/US20210299104A1/en active Pending
-
2022
- 2022-03-24 AU AU2022202035A patent/AU2022202035A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170020848A1 (en) | 2017-01-26 |
| WO2016164487A1 (en) | 2016-10-13 |
| SG11201708068PA (en) | 2017-10-30 |
| MX2022010831A (en) | 2022-09-29 |
| UY36610A (en) | 2016-10-31 |
| AR104212A1 (en) | 2017-07-05 |
| EA202090762A1 (en) | 2020-09-08 |
| BR112017021073A2 (en) | 2018-07-03 |
| IL254813A0 (en) | 2017-12-31 |
| CA2981797A1 (en) | 2016-10-13 |
| AU2020210266A1 (en) | 2020-08-20 |
| AU2016246598A1 (en) | 2017-11-02 |
| MX2017012848A (en) | 2018-01-15 |
| AU2020210266B2 (en) | 2022-03-10 |
| AU2022202035A1 (en) | 2022-04-14 |
| AU2016246598B2 (en) | 2020-07-23 |
| NZ736374A (en) | 2024-02-23 |
| JP2021050206A (en) | 2021-04-01 |
| US20210299104A1 (en) | 2021-09-30 |
| CN108055825B (en) | 2021-03-30 |
| EA036272B1 (en) | 2020-10-21 |
| JP6824900B2 (en) | 2021-02-03 |
| CO2017010065A2 (en) | 2018-01-05 |
| EA201792235A1 (en) | 2018-01-31 |
| JP2018510897A (en) | 2018-04-19 |
| IL254813B (en) | 2020-03-31 |
| KR20170134700A (en) | 2017-12-06 |
| CL2017002536A1 (en) | 2018-04-20 |
| CN108055825A (en) | 2018-05-18 |
| EP3280413A1 (en) | 2018-02-14 |
| CA2981797C (en) | 2023-11-21 |
| KR102593069B1 (en) | 2023-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL254813B (en) | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof | |
| ZA201805476B (en) | Antiparasitic isoxazoline compounds, long¿acting injectable formulations comprising them, methods and uses thereof | |
| IL249370A0 (en) | Fap-activated therapeutic agents, and uses related thereto | |
| HK1251183A1 (en) | Bioconjugates and uses thereof | |
| GB201512203D0 (en) | Agents,uses and methods | |
| SG11201705034RA (en) | Copolymer and oily gelling agent | |
| HK1256674A1 (en) | Deuterium-modified brigatinib derivatives, pharmaceutical compositions comprising same, and use thereof | |
| PL3232780T3 (en) | Aqueous electrolyte-containing adjuvant compositions, active ingredient-containing compositions and the use thereof | |
| SG11201803669UA (en) | Microorganism-controlling agent and miticidal composition | |
| HK1259291A1 (en) | Game device, game system, and program | |
| IL248586B (en) | Optically active pde10 inhibitor, compositions comprising same, proceses for preparing same and uses thereof | |
| GB201512215D0 (en) | Agents,uses and methods | |
| HK1251924A1 (en) | Foxm1-derived peptide, and vaccine including same | |
| PT3011831T (en) | Limonene: formulation and insecticide use | |
| PL3307275T3 (en) | Injectable antibiotic formulations and use thereof | |
| PL3253857T3 (en) | Aqueous formulations, their manufacture and use | |
| IL246606B (en) | Mir-122 as an active micro-rna, compositions comprising the same and uses thereof | |
| PL3072529T3 (en) | Composition comprising vemurafenib and hpmc-as | |
| SG11201700122TA (en) | Pharmaceutical compound comprising 13 glycerides, formulation and application thereof | |
| HK1251928A1 (en) | Mphosph1-derived peptide, and vaccine including same | |
| ZA201708307B (en) | Improved herbicidal composition, method and use | |
| GB201718394D0 (en) | Some alcohol ethoxyles, their application and use | |
| HUE052947T2 (en) | Immunity-inducing agent | |
| GB201518375D0 (en) | Agents,uses and methods | |
| GB201512211D0 (en) | Agents, uses and methods |