SG11201704995QA - Macromolecular conjugates for visualization and separation of proteins and cells - Google Patents

Macromolecular conjugates for visualization and separation of proteins and cells

Info

Publication number
SG11201704995QA
SG11201704995QA SG11201704995QA SG11201704995QA SG11201704995QA SG 11201704995Q A SG11201704995Q A SG 11201704995QA SG 11201704995Q A SG11201704995Q A SG 11201704995QA SG 11201704995Q A SG11201704995Q A SG 11201704995QA SG 11201704995Q A SG11201704995Q A SG 11201704995QA
Authority
SG
Singapore
Prior art keywords
visualization
proteins
cells
separation
macromolecular conjugates
Prior art date
Application number
SG11201704995QA
Other languages
English (en)
Inventor
Pavel Sacha
Jan Konvalinka
Jiri Schimer
Tomas Knedlik
Vaclav Navratil
Jan Tykvart
Frantisek Sedlak
Pavel Majer
Petr Cigler
Vladimir Subr
Karel Ulbrich
Jiri Strohalm
Original Assignee
Ustav Organicke Chemie A Biochemie Av Cr V V I
Ustav Makromolekularni Chemie Av Cr V V I
Univerzita Karlova V Praze Prirodovedecka Fakulta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ustav Organicke Chemie A Biochemie Av Cr V V I, Ustav Makromolekularni Chemie Av Cr V V I, Univerzita Karlova V Praze Prirodovedecka Fakulta filed Critical Ustav Organicke Chemie A Biochemie Av Cr V V I
Publication of SG11201704995QA publication Critical patent/SG11201704995QA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/534Production of labelled immunochemicals with radioactive label
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • C07K17/08Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/12Esters of monohydric alcohols or phenols
    • C08F220/16Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52Amides or imides
    • C08F220/54Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/58Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing oxygen in addition to the carbonamido oxygen, e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2500/00Characteristics or properties of obtained polyolefins; Use thereof
    • C08F2500/01High molecular weight, e.g. >800,000 Da.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
SG11201704995QA 2015-01-14 2016-01-13 Macromolecular conjugates for visualization and separation of proteins and cells SG11201704995QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ201520A CZ308807B6 (cs) 2015-01-14 2015-01-14 Makromolekulární konjugáty pro vizualizaci a separaci proteinů a buněk
PCT/CZ2016/050003 WO2016112883A2 (en) 2015-01-14 2016-01-13 Macromolecular conjugates for visualization and separation of proteins and cells

Publications (1)

Publication Number Publication Date
SG11201704995QA true SG11201704995QA (en) 2017-07-28

Family

ID=55411124

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201704995QA SG11201704995QA (en) 2015-01-14 2016-01-13 Macromolecular conjugates for visualization and separation of proteins and cells

Country Status (8)

Country Link
US (2) US20180052152A1 (cs)
EP (1) EP3245514B1 (cs)
AU (1) AU2016207126B2 (cs)
CA (1) CA2970913C (cs)
CZ (1) CZ308807B6 (cs)
IL (1) IL253425B (cs)
SG (1) SG11201704995QA (cs)
WO (1) WO2016112883A2 (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016202582A1 (de) 2015-06-17 2016-12-22 Clariant International Ltd Wasserlösliche oder wasserquellbare polymere als wasserverlustreduzierer in zementschlämmen
WO2018108609A1 (en) 2016-12-12 2018-06-21 Clariant International Ltd Polymer comprising certain level of bio-based carbon
ES2867526T3 (es) 2016-12-12 2021-10-20 Clariant Int Ltd Uso de un polímero bioderivado en una composición cosmética, dermatológica o farmacéutica
WO2018108663A1 (en) 2016-12-15 2018-06-21 Clariant International Ltd Water-soluble and/or water-swellable hybrid polymer
WO2018108667A1 (en) 2016-12-15 2018-06-21 Clariant International Ltd Water-soluble and/or water-swellable hybrid polymer
EP3554644B1 (en) 2016-12-15 2025-03-19 Clariant International Ltd Water-soluble and/or water-swellable hybrid polymer
ES3033231T3 (en) 2016-12-15 2025-07-31 Clariant Int Ltd Water-soluble and/or water-swellable hybrid polymer
CZ310444B6 (cs) * 2021-09-13 2025-06-25 Ústav makromolekulární chemie AV ČR, v. v. i. Fluorescenčně značený polymer pro vizualizaci nádorů a jeho použití
CZ310462B6 (cs) * 2022-04-22 2025-07-09 Ústav makromolekulární chemie AV ČR, v. v. i. Polymerní konjugát pro blokování nespecifických interakcí v imunochemických stanoveních, způsob jeho výroby a jeho použití

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
EP1204488B1 (de) * 2000-06-02 2008-09-17 Eppendorf Ag Verfahren zur herstellung von als ausgangsprodukte für mikroarrays dienenden oberflächenfunktionalisierten trägern zur immobilisierung von biomolekülen
US7662360B2 (en) * 2002-07-22 2010-02-16 Psimei Pharmaceuticals Plc Conjugates of N-hydroxypropymethacrylamide-methacrylate copolymer with nuclide activation agent and/or anti-cancer compounds
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
EP2362220A1 (en) * 2010-02-25 2011-08-31 Corning Incorporated Affinity hydrogel and label independent detection methods thereof

Also Published As

Publication number Publication date
WO2016112883A3 (en) 2016-08-25
CA2970913A1 (en) 2016-07-21
US10302632B2 (en) 2019-05-28
EP3245514A2 (en) 2017-11-22
US20180052152A1 (en) 2018-02-22
IL253425B (en) 2019-09-26
CZ308807B6 (cs) 2021-06-02
EP3245514B1 (en) 2019-07-10
CA2970913C (en) 2019-08-06
WO2016112883A2 (en) 2016-07-21
IL253425A0 (en) 2017-09-28
CZ201520A3 (cs) 2016-07-27
AU2016207126B2 (en) 2018-11-29
AU2016207126A1 (en) 2017-07-13
US20190033300A1 (en) 2019-01-31

Similar Documents

Publication Publication Date Title
IL322085A (en) Compositions and methods for reducing unfolded proteins
IL253425A0 (en) Macromolecular conjugates for imaging and separation of proteins and cells
IL248361A0 (en) Recombinant host cell for expression of desired proteins
EP3149025A4 (en) Cell penetrating peptides and methods of making and using thereof
SG11201607796TA (en) Nanopore-based analysis of protein characteristics
HUE049641T2 (hu) Szeparátor elektrokémiai elemhez és elektrokémiai elem
ZA201606987B (en) Methods and compositions for detecting misfolded proteins
IL290358A (en) Preparations and methods for detecting host cell proteins
ZA201705712B (en) Host cell protein modification
IL257170A (en) Stable proteins and methods for their design
EP3268477A4 (en) Structure based methods for modification of pip-72 polypeptides and pip-72 polypeptides derived therefrom
EP3248679A4 (en) Separation material
GB201515745D0 (en) Proteins
GB201511787D0 (en) Proteins
EP3358585A4 (en) SEPARATOR FOR ELECTROCHEMICAL ELEMENT AND ELECTROCHEMICAL ELEMENT
EP3243902A4 (en) Luterion and separating and culturing methods for same
EP3248678A4 (en) Separation material
SG11201702516UA (en) Novel selection marker for cell transfection and protein production
GB201513033D0 (en) Proteins
EP3105254A4 (en) Hybrid proteins and uses thereof
GB201518675D0 (en) Detection of structural forms of proteins
IL253406A0 (en) Macromolecular conjugates for isolation, immobilization and imaging of proteins
EP3209697A4 (en) Fn14-binding proteins and uses thereof
HK40092181A (en) Methods and compositions for detecting misfolded proteins
AU2015901368A0 (en) Molecules and methods for inducing cell death