SG11201703127SA - Antisense-oligonucleotides as inhibitors of tgf-r signaling - Google Patents

Antisense-oligonucleotides as inhibitors of tgf-r signaling

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Publication number
SG11201703127SA
SG11201703127SA SG11201703127SA SG11201703127SA SG11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA
Authority
SG
Singapore
Prior art keywords
tgf
antisense
oligonucleotides
inhibitors
signaling
Prior art date
Application number
SG11201703127SA
Other languages
English (en)
Inventor
Markus Hossbach
Monika Krampert
Hans-Lothar Arth
Original Assignee
Neurovision Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurovision Pharma GmbH filed Critical Neurovision Pharma GmbH
Publication of SG11201703127SA publication Critical patent/SG11201703127SA/en

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)

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SG11201703127SA 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling SG11201703127SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

Publications (1)

Publication Number Publication Date
SG11201703127SA true SG11201703127SA (en) 2017-06-29

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SG11201703127SA SG11201703127SA (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

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US (4) US11213541B2 (zh)
EP (3) EP3020813A1 (zh)
JP (2) JP6832285B2 (zh)
KR (2) KR102417601B1 (zh)
CN (2) CN113151261A (zh)
AU (3) AU2015345006B2 (zh)
BR (1) BR112017006201B1 (zh)
CA (2) CA3201845C (zh)
CL (2) CL2017001233A1 (zh)
CY (1) CY1121110T1 (zh)
DK (1) DK3218488T3 (zh)
ES (1) ES2705066T3 (zh)
HU (1) HUE041793T2 (zh)
IL (2) IL251565B (zh)
MX (2) MX2017006369A (zh)
MY (1) MY181404A (zh)
PL (1) PL3218488T3 (zh)
PT (1) PT3218488T (zh)
RU (1) RU2717454C2 (zh)
SG (1) SG11201703127SA (zh)
TR (1) TR201900844T4 (zh)
WO (1) WO2016075339A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
JP7476102B2 (ja) * 2017-12-22 2024-04-30 ロシュ イノベーション センター コペンハーゲン エーエス ホスホロジチオアートヌクレオシド間結合を含むオリゴヌクレオチド
WO2019122277A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Novel thiophosphoramidites
JP7476101B2 (ja) * 2017-12-22 2024-04-30 ロシュ イノベーション センター コペンハーゲン エーエス ホスホロジチオアートヌクレオシド間結合を含むギャップマーオリゴヌクレオチド
WO2022094320A2 (en) * 2020-10-29 2022-05-05 Garcia Blanco Mariano A Soluble interleukin-7 receptor (sil7r) modulating therapy to treat cancer
CN114588160A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有抗肺纤维化作用的次黄碱衍生物
CN113992687B (zh) * 2021-12-28 2022-04-08 浙江宇视科技有限公司 智能业务集群调度方法、装置、电子设备及存储介质

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1092988C (zh) 1996-02-19 2002-10-23 奈科姆成像有限公司 热稳定的造影剂
US20030064944A1 (en) * 2001-06-21 2003-04-03 Isis Pharmaceuticals Inc. Antisense modulation of transforming growth factor beta receptor II expression
DK2752488T3 (da) 2002-11-18 2020-04-20 Roche Innovation Ct Copenhagen As Antisense-design
NZ545544A (en) * 2003-08-13 2009-04-30 Univ Illinois Silencing of TGF-beta receptor type II expression by sirna
MXPA06008964A (es) * 2004-02-09 2007-02-02 Regenion Gmbh Inhibidores de la senalizacion de tgf-r para el tratamiento de enfermedades del snc.
WO2007031091A2 (en) 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
CA2640171C (en) 2006-01-27 2014-10-28 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
CA3042781C (en) 2006-04-03 2021-10-19 Roche Innovation Center Copenhagen A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
WO2007134181A2 (en) 2006-05-11 2007-11-22 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
US9398493B2 (en) 2006-10-30 2016-07-19 Nokia Technologies Oy Method, apparatus, and system providing operator controlled mobility for user equipment
WO2008109546A2 (en) 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof
US8278425B2 (en) 2007-05-30 2012-10-02 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
CA2692579C (en) 2007-07-05 2016-05-03 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
US20110119781A1 (en) * 2008-07-15 2011-05-19 Birgit Bramlage Compositions and Methods for Inhibiting Expression of TGF-BETA Receptor Genes
ES2651308T3 (es) * 2009-10-16 2018-01-25 Glaxo Group Limited Inhibidores antisentido de HBV
CN103068983A (zh) * 2010-06-11 2013-04-24 安提森斯制药有限公司 用于选择性寡核苷酸修饰的方法
US9115371B2 (en) * 2011-08-18 2015-08-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reduction of TGF beta signaling in myeloid cells in the treatment of cancer
CN104004762B (zh) * 2014-05-20 2016-03-30 南京医科大学附属南京儿童医院 Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling

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