SG11201609285SA - Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer - Google Patents
Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancerInfo
- Publication number
- SG11201609285SA SG11201609285SA SG11201609285SA SG11201609285SA SG11201609285SA SG 11201609285S A SG11201609285S A SG 11201609285SA SG 11201609285S A SG11201609285S A SG 11201609285SA SG 11201609285S A SG11201609285S A SG 11201609285SA SG 11201609285S A SG11201609285S A SG 11201609285SA
- Authority
- SG
- Singapore
- Prior art keywords
- ctla
- antibodies
- lung cancer
- small cell
- cell lung
- Prior art date
Links
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461992658P | 2014-05-13 | 2014-05-13 | |
| US201562105992P | 2015-01-21 | 2015-01-21 | |
| US201562114336P | 2015-02-10 | 2015-02-10 | |
| PCT/EP2015/060523 WO2015173267A1 (en) | 2014-05-13 | 2015-05-12 | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201609285SA true SG11201609285SA (en) | 2016-12-29 |
Family
ID=53175516
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201810108PA SG10201810108PA (en) | 2014-05-13 | 2015-05-12 | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer |
| SG11201609285SA SG11201609285SA (en) | 2014-05-13 | 2015-05-12 | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201810108PA SG10201810108PA (en) | 2014-05-13 | 2015-05-12 | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10232040B2 (ko) |
| EP (2) | EP3142751B1 (ko) |
| JP (4) | JP6648038B2 (ko) |
| KR (4) | KR20210149870A (ko) |
| CN (2) | CN106456756B (ko) |
| AU (3) | AU2015260962B2 (ko) |
| BR (2) | BR122023025321A2 (ko) |
| CA (1) | CA2947471A1 (ko) |
| CY (1) | CY1122642T1 (ko) |
| DK (1) | DK3142751T3 (ko) |
| ES (1) | ES2749098T3 (ko) |
| GB (1) | GB2531094A (ko) |
| HR (1) | HRP20191449T1 (ko) |
| HU (1) | HUE045965T2 (ko) |
| IL (2) | IL248528B (ko) |
| LT (1) | LT3142751T (ko) |
| ME (1) | ME03493B (ko) |
| MX (1) | MX2016014189A (ko) |
| PL (1) | PL3142751T3 (ko) |
| PT (1) | PT3142751T (ko) |
| RS (1) | RS59134B1 (ko) |
| RU (1) | RU2702332C2 (ko) |
| SG (2) | SG10201810108PA (ko) |
| SI (1) | SI3142751T1 (ko) |
| TW (3) | TWI707692B (ko) |
| WO (1) | WO2015173267A1 (ko) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20240056664A (ko) | 2013-09-11 | 2024-04-30 | 메디뮨 리미티드 | 종양 치료용 항-ｂ7-ｈ1 항체 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| AU2015260962B2 (en) * | 2014-05-13 | 2020-06-11 | Medimmune Limited | Anti-B7-H1 and anti-CTLA-4 antibodies for treating non-small cell lung cancer |
| GB2535256A (en) * | 2014-08-28 | 2016-08-17 | Medimmune Ltd | Combination therapy for PD-L1 negative tumors |
| WO2016030455A1 (en) * | 2014-08-28 | 2016-03-03 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer |
| MX2017011644A (es) | 2015-03-13 | 2017-12-04 | Cytomx Therapeutics Inc | Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos. |
| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| TW201735949A (zh) | 2016-03-24 | 2017-10-16 | 千禧製藥公司 | 治療抗ctla4及抗pd-1組合治療中的胃腸道免疫相關不良事件之方法 |
| US10421811B2 (en) * | 2016-04-25 | 2019-09-24 | Medimmune, Llc | Compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies |
| CN109863251B (zh) * | 2016-05-17 | 2022-11-18 | 基因中心治疗公司 | 对肺鳞状细胞癌亚型分型的方法 |
| WO2017201165A1 (en) * | 2016-05-17 | 2017-11-23 | Genecentric Diagnostics, Inc. | Methods for subtyping of lung adenocarcinoma |
| CN109475603B (zh) | 2016-06-20 | 2023-06-13 | 科马布有限公司 | 抗pd-l1抗体 |
| WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| JP7198752B2 (ja) | 2016-08-09 | 2023-01-04 | カイマブ・リミテッド | 抗ｉｃｏｓ抗体 |
| RU2019110071A (ru) | 2016-09-06 | 2020-10-08 | Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч | Способы лечения злокачественных новообразований, экспрессирующих pd-l1 |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| EP3538142A4 (en) * | 2016-11-11 | 2020-07-01 | Medimmune, LLC | ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| JP7300394B2 (ja) | 2017-01-17 | 2023-06-29 | ヘパリジェニックス ゲーエムベーハー | 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害 |
| CA3052652A1 (en) * | 2017-02-16 | 2018-08-23 | John KURLAND | Anti-pd-l1 antibody treatment of bladder cancer |
| BR112019025188A2 (pt) | 2017-06-01 | 2020-06-23 | Cytomx Therapeutics, Inc. | Anticorpos anti-pdl1 ativáveis e métodos de uso dos mesmos |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| US11629189B2 (en) | 2017-12-19 | 2023-04-18 | Kymab Limited | Bispecific antibody for ICOS and PD-L1 |
| GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
| EA202092043A1 (ru) * | 2018-03-08 | 2020-12-28 | Астразенека Аб | Композиции и способы для лечения рака легкого на поздней стадии |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| JP7487558B2 (ja) | 2020-05-25 | 2024-05-21 | 船井電機株式会社 | 面光源装置および表示装置 |
| JP2023532768A (ja) | 2020-07-07 | 2023-07-31 | バイオエヌテック エスエー | Ｈｐｖ陽性癌の治療用ｒｎａ |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| TW202304506A (zh) | 2021-03-25 | 2023-02-01 | 日商安斯泰來製藥公司 | 涉及抗claudin 18.2抗體的組合治療以治療癌症 |
| WO2022243378A1 (en) | 2021-05-18 | 2022-11-24 | Kymab Limited | Uses of anti-icos antibodies |
| GB202107994D0 (en) | 2021-06-04 | 2021-07-21 | Kymab Ltd | Treatment of cancer |
| KR20240046323A (ko) | 2021-07-13 | 2024-04-08 | 비온테크 에스이 | 암에 대한 병용 요법에 있어서 cd40 및 cd137에 대한 다중특이 결합제 |
| WO2023051926A1 (en) | 2021-09-30 | 2023-04-06 | BioNTech SE | Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| AU2022377644A1 (en) * | 2021-10-29 | 2024-05-16 | OncoC4, Inc. | Anti-ctla-4 antibody dosing regimens |
| WO2023083439A1 (en) | 2021-11-09 | 2023-05-19 | BioNTech SE | Tlr7 agonist and combinations for cancer treatment |
| WO2023222854A1 (en) | 2022-05-18 | 2023-11-23 | Kymab Limited | Uses of anti-icos antibodies |
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| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
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| CN101248089A (zh) * | 2005-07-01 | 2008-08-20 | 米德列斯公司 | 抗程序性死亡配体1（pd-l1）的人单克隆抗体 |
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| EP3542820A1 (en) | 2010-11-05 | 2019-09-25 | Novartis AG | Methods of treating psoriatic arthritis using il-17 antagonists |
| CN101975831B (zh) * | 2010-11-25 | 2012-09-05 | 中国检验检疫科学研究院 | 高效液相色谱法测定化妆品中苯酚磺酸锌的方法 |
| CN102836441B (zh) * | 2011-06-24 | 2019-06-11 | 台北荣民总医院 | 于感染性与恶性疾病的治疗中提升免疫反应的方法 |
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| JP6448533B2 (ja) * | 2012-05-15 | 2019-01-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｐｄ−１／ｐｄ−ｌ１シグナル伝達を破壊することによる癌免疫療法 |
| US10034939B2 (en) | 2012-10-26 | 2018-07-31 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
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| SG10201707135RA (en) * | 2013-03-01 | 2017-10-30 | Astex Pharmaceuticals Inc | Drug combinations |
| AU2015260962B2 (en) * | 2014-05-13 | 2020-06-11 | Medimmune Limited | Anti-B7-H1 and anti-CTLA-4 antibodies for treating non-small cell lung cancer |
| WO2016030455A1 (en) * | 2014-08-28 | 2016-03-03 | Medimmune Limited | Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small lung cancer |
| DK3218406T3 (da) * | 2014-11-10 | 2021-06-21 | Medimmune Ltd | Bindingsmolekyler, der er specifikke for cd73, og anvendelser deraf |
| CN113577264A (zh) * | 2015-04-17 | 2021-11-02 | 百时美施贵宝公司 | 包含抗pd-1抗体和另外的抗体的组合的组合物 |
| US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
| CA3052652A1 (en) * | 2017-02-16 | 2018-08-23 | John KURLAND | Anti-pd-l1 antibody treatment of bladder cancer |
-
2015
- 2015-05-12 AU AU2015260962A patent/AU2015260962B2/en active Active
- 2015-05-12 WO PCT/EP2015/060523 patent/WO2015173267A1/en active Application Filing
- 2015-05-12 BR BR122023025321-3A patent/BR122023025321A2/pt unknown
- 2015-05-12 HU HUE15722195A patent/HUE045965T2/hu unknown
- 2015-05-12 BR BR112016026197-6A patent/BR112016026197A2/pt active Search and Examination
- 2015-05-12 PT PT157221953T patent/PT3142751T/pt unknown
- 2015-05-12 RS RS20191070A patent/RS59134B1/sr unknown
- 2015-05-12 JP JP2016567088A patent/JP6648038B2/ja active Active
- 2015-05-12 SI SI201530857T patent/SI3142751T1/sl unknown
- 2015-05-12 CN CN201580024117.6A patent/CN106456756B/zh active Active
- 2015-05-12 ES ES15722195T patent/ES2749098T3/es active Active
- 2015-05-12 PL PL15722195T patent/PL3142751T3/pl unknown
- 2015-05-12 RU RU2016148645A patent/RU2702332C2/ru active
- 2015-05-12 GB GB1508097.1A patent/GB2531094A/en not_active Withdrawn
- 2015-05-12 EP EP15722195.3A patent/EP3142751B1/en active Active
- 2015-05-12 KR KR1020217038830A patent/KR20210149870A/ko not_active Application Discontinuation
- 2015-05-12 MX MX2016014189A patent/MX2016014189A/es active IP Right Grant
- 2015-05-12 SG SG10201810108PA patent/SG10201810108PA/en unknown
- 2015-05-12 CN CN202110380316.8A patent/CN113230398A/zh active Pending
- 2015-05-12 ME MEP-2019-231A patent/ME03493B/me unknown
- 2015-05-12 US US14/710,101 patent/US10232040B2/en active Active
- 2015-05-12 KR KR1020227040764A patent/KR20220162844A/ko active Application Filing
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