SG11201608785PA - Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease - Google Patents

Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease

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Publication number
SG11201608785PA
SG11201608785PA SG11201608785PA SG11201608785PA SG11201608785PA SG 11201608785P A SG11201608785P A SG 11201608785PA SG 11201608785P A SG11201608785P A SG 11201608785PA SG 11201608785P A SG11201608785P A SG 11201608785PA SG 11201608785P A SG11201608785P A SG 11201608785PA
Authority
SG
Singapore
Prior art keywords
alloesteric
isoindoline
derivatives
treatment
receptor positive
Prior art date
Application number
SG11201608785PA
Other languages
English (en)
Inventor
Masami Yamada
Shinkichi Suzuki
Takahiro Sugimoto
Minoru Nakamura
Hiroki Sakamoto
Makoto Kamata
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201608785P(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of SG11201608785PA publication Critical patent/SG11201608785PA/en

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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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SG11201608785PA 2014-04-23 2015-04-22 Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease SG11201608785PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014089585 2014-04-23
PCT/JP2015/062912 WO2015163485A1 (en) 2014-04-23 2015-04-22 Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease

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SG11201608785PA true SG11201608785PA (en) 2016-11-29

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EP (1) EP3134386B1 (enrdf_load_stackoverflow)
JP (1) JP6517239B2 (enrdf_load_stackoverflow)
KR (1) KR102349237B1 (enrdf_load_stackoverflow)
CN (1) CN106536508B (enrdf_load_stackoverflow)
AR (1) AR100154A1 (enrdf_load_stackoverflow)
AU (1) AU2015250610B2 (enrdf_load_stackoverflow)
BR (1) BR112016024472B1 (enrdf_load_stackoverflow)
CA (1) CA2946519C (enrdf_load_stackoverflow)
CL (1) CL2016002661A1 (enrdf_load_stackoverflow)
CR (1) CR20160544A (enrdf_load_stackoverflow)
CY (1) CY1123569T1 (enrdf_load_stackoverflow)
DK (1) DK3134386T3 (enrdf_load_stackoverflow)
DO (1) DOP2016000286A (enrdf_load_stackoverflow)
EA (1) EA030373B1 (enrdf_load_stackoverflow)
EC (1) ECSP16090152A (enrdf_load_stackoverflow)
ES (1) ES2811088T3 (enrdf_load_stackoverflow)
HR (1) HRP20201171T1 (enrdf_load_stackoverflow)
HU (1) HUE050543T2 (enrdf_load_stackoverflow)
IL (1) IL248393B (enrdf_load_stackoverflow)
LT (1) LT3134386T (enrdf_load_stackoverflow)
MX (1) MX373274B (enrdf_load_stackoverflow)
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NZ (1) NZ725921A (enrdf_load_stackoverflow)
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PH (1) PH12016502095B1 (enrdf_load_stackoverflow)
PL (1) PL3134386T3 (enrdf_load_stackoverflow)
PT (1) PT3134386T (enrdf_load_stackoverflow)
RS (1) RS60524B1 (enrdf_load_stackoverflow)
SG (1) SG11201608785PA (enrdf_load_stackoverflow)
SI (1) SI3134386T1 (enrdf_load_stackoverflow)
TN (1) TN2016000455A1 (enrdf_load_stackoverflow)
TW (1) TWI664165B (enrdf_load_stackoverflow)
UA (1) UA122391C2 (enrdf_load_stackoverflow)
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